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Recognition of physiological phosphorylation sites by p21-activated kinase 4

Journal Article · · Journal of Structural Biology
Not Available
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1702048
Alternate ID(s):
OSTI ID: 1635691
Journal Information:
Journal of Structural Biology, Journal Name: Journal of Structural Biology Journal Issue: 3 Vol. 211; ISSN 1047-8477
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (57)

p120-catenin is a binding partner and substrate for Group B Pak kinases journal May 2010
LIM kinases: function, regulation and association with human disease journal February 2007
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Lim kinases, regulators of actin dynamics journal January 2007
Understanding and exploiting substrate recognition by protein kinases journal February 2008
A PAK4–LIMK1 pathway drives prostate cancer cell migration downstream of HGF journal July 2008
P21-activated kinase 4 – Not just one of the PAK journal April 2013
Structure, biochemistry, and biology of PAK kinases journal March 2017
Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity journal January 2014
Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases journal May 2016
Homing in: Mechanisms of Substrate Targeting by Protein Kinases journal May 2018
Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition journal April 2006
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics journal July 1999
PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas journal September 2017
Data publication with the structural biology data grid supports live analysis journal March 2016
An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 journal November 2015
Assay of protein kinases using radiolabeled ATP: a protocol journal August 2006
Mechanisms of specificity in protein phosphorylation journal July 2007
PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis journal July 2013
A tale of two Paks journal February 2008
The emerging importance of group II PAKs journal January 2010
LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505 journal February 2001
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate journal September 2012
CDC42 binds PAK4 via an extended GTPase-effector interface journal January 2018
Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop journal February 2000
Activation of LIM Kinases by Myotonic Dystrophy Kinase-related Cdc42-binding Kinase α journal June 2001
The Effects of Changing the Site of Activating Phosphorylation in CDK2 from Threonine to Serine journal October 2000
Specific Activation of LIM kinase 2 via Phosphorylation of Threonine 505 by ROCK, a Rho-dependent Protein Kinase journal October 2000
The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis journal April 2001
Cytoskeletal Changes Regulated by the PAK4 Serine/Threonine Kinase Are Mediated by LIM Kinase 1 and Cofilin journal August 2001
Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines journal January 2002
p21-activated Kinase 4 Phosphorylation of Integrin β5 Ser-759 and Ser-762 Regulates Cell Migration journal July 2010
The Mechanism of p21-activated Kinase 2 Autoactivation journal October 2003
Specificity Profiling of Pak Kinases Allows Identification of Novel Phosphorylation Sites journal May 2007
Signaling, Regulation, and Specificity of the Type II p21-activated Kinases journal April 2015
Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis journal August 2010
How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase. journal October 1995
Phaser crystallographic software journal July 2007
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Features and development of Coot journal March 2010
Presenting your structures: the CCP 4 mg molecular-graphics software journal March 2011
mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin journal July 2013
Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase journal August 1999
Activated PAK4 Regulates Cell Adhesion and Anchorage-Independent Growth journal May 2001
Pak4 Induces Premature Senescence via a Pathway Requiring p16 INK4 /p19 ARF and Mitogen-Activated Protein Kinase Signaling journal November 2005
Structural Framework for the Protein Kinase Family journal November 1992
PAK4 Phosphorylates p53 at Serine 215 to Promote Liver Cancer Metastasis journal August 2016
Overexpression of P21-activated kinase 4 is associated with poor prognosis in non-small cell lung cancer and promotes migration and invasion journal May 2015
The genetics of Pak journal September 2004
PAK4 mediates morphological changes through the regulation of GEF-H1 journal May 2005
PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion journal May 2010
LIM Kinase 2 Is Widely Expressed in All Tissues journal January 2006
Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output journal March 2019
Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization journal August 2017
p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells journal November 2015
PAK4 pathway as a potential therapeutic target in pancreatic cancer journal March 2018

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