Amorphous Ag2-xCuxS quantum dots: “all-in-one” theranostic nanomedicines for near-infrared fluorescence/photoacoustics dual-modal-imaging-guided photothermal therapy

Zhao, Yangyang; Song, Miao; Yang, Xiaoguang; Yang, Jian; Du, Chunyan; Wang, Guannan; Yi, Jingwen; Shan, Guiye; Li, Dongsheng; Liu, Lei; Yan, Dongmei; Li, Yuxin; Liu, Xiaojie

doi:10.1016/j.cej.2020.125777

Title: Amorphous Ag_2-xCu_xS quantum dots: “all-in-one” theranostic nanomedicines for near-infrared fluorescence/photoacoustics dual-modal-imaging-guided photothermal therapy

Journal Article · Mon Jun 08 00:00:00 EDT 2020 · Chemical Engineering Journal

DOI:https://doi.org/10.1016/j.cej.2020.125777· OSTI ID:1700515

Zhao, Yangyang ^[1]; Song, Miao ^[2]; Yang, Xiaoguang ^[1]; Yang, Jian ^[1]; Du, Chunyan ^[1]; Wang, Guannan ^[1]; Yi, Jingwen ^[1]; Shan, Guiye ^[1];

^[3]; Liu, Lei ^[1]; Yan, Dongmei ^[4]; Li, Yuxin ^[1]; Liu, Xiaojie ^[1]

Northeast Normal Univ., Changchun (China)
BATTELLE (PACIFIC NW LAB)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Jilin Univ., Changchun (China)

Integrating dual-modal imaging and photothermal effect within a single nanosystem is an enormous challenge for current nanomedicine application. In this study, non-toxic amorphous Ag_2-xCu_xS quantum dots (QDs) possessing near-infrared fluorescence (NIRF), enhanced photothermal and photoacoustic (PA) performance, as “one-in-all” nanomedicines, are designed and obtained. Cu doping in amorphous Ag₂S QDs causes red-shift of NIRF to the lowest tissue absorption wavelength in so called “first biowindow” (~820 nm) and improves photothermal conversion efficiency to 44.0% simultaneously. Density functional theory simulation results suggest the fluorescence red-shift and enhanced photothermal/photoacoustics properties can be attributed to the generation of intragap states introduced by Cu doping. The amorphous Ag_2-xCu_xS QDs exhibit high long-term biocompatibility. Under a single laser irradiation with relatively low power density, an effective tumor ablation induced by high photothermal effect of amorphous Ag_2-xCu_xS QDs is achieved in vivo. Simultaneously, the PTT process can be guided by high quality NIRF/PA dual-modal-imaging.

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Research Organization:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE Office of Science (SC), Biological and Environmental Research (BER); National Natural Science Foundation of China (NSFC)

Grant/Contract Number:: AC05-76RL01830; 67037; 11774048

OSTI ID:: 1700515

Alternate ID(s):: OSTI ID: 1703931

Report Number(s):: PNNL-SA-140492

Journal Information:: Chemical Engineering Journal, Vol. 399; ISSN 1385-8947

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Related Subjects

36 MATERIALS SCIENCE
amorphous
Ag2-xCuxS quantum dots
photothermal therapy
near-infrared fluorescence
photoacoustics
multimodal imaging

Title: Amorphous Ag2-xCuxS quantum dots: “all-in-one” theranostic nanomedicines for near-infrared fluorescence/photoacoustics dual-modal-imaging-guided photothermal therapy

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Title: Amorphous Ag_2-xCu_xS quantum dots: “all-in-one” theranostic nanomedicines for near-infrared fluorescence/photoacoustics dual-modal-imaging-guided photothermal therapy