Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

Mpakali, A; Saridakis, E.; Giastas, P.; Maben, Z.; Stern, L.; Larhed, M.; Hallberg, M.; Stratikos, E.

doi:10.1021/acsmedchemlett.0c00172

Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

Journal Article · Fri Jan 01 04:00:00 EST 2021 · ACS Medicinal Chemistry Letters

DOI:https://doi.org/10.1021/acsmedchemlett.0c00172· OSTI ID:1690159

Mpakali, A; Saridakis, E.; Giastas, P.; Maben, Z.; Stern, L.; Larhed, M.; Hallberg, M.; Stratikos, E.

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: ~OTHER

DOE Contract Number:: SC0012704

OSTI ID:: 1690159

Report Number(s):: BNL-220481-2020-JACI

Journal Information:: ACS Medicinal Chemistry Letters, Journal Name: ACS Medicinal Chemistry Letters Journal Issue: 7 Vol. 11; ISSN 1948-5875

Country of Publication:: United States

Language:: English

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Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild Molecular Pharmacology, Vol. 89, Issue 4 https://doi.org/10.1124/mol.115.102533	journal	January 2016
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Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity Mpakali, Anastasia; Saridakis, Emmanuel; Harlos, Karl Journal of Medicinal Chemistry, Vol. 60, Issue 7 https://doi.org/10.1021/acs.jmedchem.6b01890	journal	April 2017
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Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing Mpakali, Anastasia; Saridakis, Emmanuel; Harlos, Karl The Journal of Immunology, Vol. 195, Issue 6 https://doi.org/10.4049/jimmunol.1501103	journal	August 2015
The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing* Wong, Alan H. M.; Zhou, Dongxia; Rini, James M. Journal of Biological Chemistry, Vol. 287, Issue 44 https://doi.org/10.1074/jbc.M112.398842	journal	October 2012
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