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Title: Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors.

Journal Article · · Journal of Medicinal Chemistry

Research Organization:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704
OSTI ID:
1689952
Report Number(s):
BNL-220281-2020-JACI
Journal Information:
Journal of Medicinal Chemistry, Vol. 183
Country of Publication:
United States
Language:
English

References (38)

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Piperazine-Derivative MMV665917: An Effective Drug in the Diarrheic Piglet Model of Cryptosporidium hominis journal March 2019
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Explaining an Unusually Fast Parasitic Enzyme: Folate Tail-Binding Residues Dictate Substrate Positioning and Catalysis in Cryptosporidium hominis Thymidylate Synthase journal August 2008
Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase–dihydrofolate reductase journal September 2014
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Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein–protein interaction in C. hominis thymidylate synthase-dihydrofolate reductase (TS-DHFR) journal January 2013
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Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase journal June 2019
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