Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Structural insights into melatonin receptors

Journal Article · · Federation of European Biochemical Societies (FEBS) Journal
DOI:https://doi.org/10.1111/febs.15128· OSTI ID:1689936
Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
~OTHER
DOE Contract Number:
SC0012704
OSTI ID:
1689936
Report Number(s):
BNL-220265-2020-JACI
Journal Information:
Federation of European Biochemical Societies (FEBS) Journal, Journal Name: Federation of European Biochemical Societies (FEBS) Journal Journal Issue: 8 Vol. 287; ISSN 1742-464X
Country of Publication:
United States
Language:
English

References (83)

Important amino acids for the function of the human MT1 melatonin receptor journal May 2003
Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder journal December 2014
G-protein-coupled receptors at a glance journal December 2003
Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment: Toxicology of chronic melatonin journal November 2000
The Retinal Conformation and its Environment in Rhodopsin in Light of a New 2.2Å Crystal Structure journal September 2004
Emerging structural biology of lipid G protein-coupled receptors: Structural Biology of Lipid G Protein-Coupled Receptors journal January 2019
Crystal Structure of a Lipid G Protein-Coupled Receptor journal February 2012
Recent developments in CrystFEL journal March 2016
Stabilization of G protein-coupled receptors by point mutations journal April 2015
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes journal January 2012
Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors journal June 2012
Structural Basis for Molecular Recognition at Serotonin Receptors journal March 2013
Molecular basis for high-affinity agonist binding in GPCRs journal May 2019
The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization journal June 2006
Importance of the second extracellular loop for melatonin MT 1 receptor function and absence of melatonin binding in GPR50 : E2 loop in MT journal October 2017
MT 1 and MT 2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential journal November 2013
Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs journal October 2019
Microscale Fluorescent Thermal Stability Assay for Membrane Proteins journal March 2008
New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation: Melatonin in human sleep and circadian rhythms journal January 2018
A comprehensive map of molecular drug targets journal December 2016
Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies journal March 2012
Synthesis of a Novel Series of Tricyclic Indan Derivatives as Melatonin Receptor Agonists journal August 2002
Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2C Receptor Heteromers journal May 2015
O-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors journal April 2019
Melatonin as a chronobiotic journal February 2005
LCP-FRAP Assay for Pre-Screening Membrane Proteins for In Meso Crystallization journal December 2008
5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology journal February 2018
Homology Models of Melatonin Receptors: Challenges and Recent Advances journal April 2013
The ChEMBL bioactivity database: an update journal November 2013
Crystal Structure of the Human Cannabinoid Receptor CB2 journal January 2019
Melatonin—A pleiotropic, orchestrating regulator molecule journal March 2011
Mutagenesis studies of the human MT2 melatonin receptor journal July 2003
Entrainment of Free-Running Circadian Rhythms by Melatonin in Blind People journal October 2000
Clinical pharmacokinetics of melatonin: a systematic review journal May 2015
Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties: Pharmacological properties of the antidepressant agomelatine journal July 2014
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser journal July 2015
How Can Mutations Thermostabilize G-Protein-Coupled Receptors? journal January 2016
The Highly Conserved DRY Motif of Class A G Protein-Coupled Receptors: Beyond the Ground State journal December 2006
Crystal structures of agonist-bound human cannabinoid receptor CB1 journal July 2017
The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints journal June 2003
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant journal December 2014
Recent Progress in the Development of Agonists and Antagonists for Melatonin Receptors journal June 2012
Dynamic tuneable G protein-coupled receptor monomer-dimer populations journal April 2018
XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity journal April 2019
Serial Femtosecond Crystallography of G Protein-Coupled Receptors journal December 2013
Type 2 diabetes–associated variants of the MT 2 melatonin receptor affect distinct modes of signaling journal August 2018
Sleep and sleep disturbances: biological basis and clinical implications journal March 2007
Structural biology of G protein-coupled receptors: new opportunities from XFELs and cryoEM journal August 2018
Structural Features for Functional Selectivity at Serotonin Receptors journal March 2013
System-level identification of transcriptional circuits underlying mammalian circadian clocks journal January 2005
Functional MT1 and MT2 Melatonin Receptors in Mammals journal January 2005
Lipidic cubic phase technologies for membrane protein structural studies journal August 2011
Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?: Melatonin receptors journal July 2008
Ramelteon: Profile of a new sleep-promoting medication journal January 2006
Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1 journal June 2015
Melatonin Receptor Agonists: SAR and Applications to the Treatment of Sleep-Wake Disorders journal July 2008
Structural basis of ligand recognition at the human MT1 melatonin receptor journal April 2019
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography journal February 2014
Homology modeling of MT1 and MT2 receptors journal September 2008
Update on melatonin receptors: IUPHAR Review 20: Melatonin receptors journal August 2016
Melatonin as a Hormone: New Physiological and Clinical Insights journal September 2018
Heteromeric MT 1 /MT 2 Melatonin Receptors Modulate Photoreceptor Function journal October 2013
High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography journal May 2012
Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface journal December 2018
The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine 2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways journal May 2003
The Study of the Mechanism of Binding of Human ML1A Melatonin Receptor Ligands Using Molecular Modeling journal January 2004
GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals journal April 2008
G Protein–Coupled Receptor Oligomerization Revisited: Functional and Pharmacological Perspectives journal February 2014
The Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS) journal March 2010
Finding New Clock Components: Past and Future journal October 2004
Suprachiasmatic control of melatonin synthesis in rats: inhibitory and stimulatory mechanisms: Melatonin synthesis controlled by clock outputs journal January 2003
Melatonin journal March 2006
Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor journal December 2018
Fingerprinting G-protein-coupled receptors journal January 1994
[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors book January 1995
Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine journal February 2019
Toward G protein-coupled receptor structure-based drug design using X-ray lasers journal October 2019
The structure and function of G-protein-coupled receptors journal May 2009
Serial Femtosecond Crystallography of G Protein–Coupled Receptors journal May 2018
Circadian Rhythms in Man: A self-sustained oscillator with an inherent frequency underlies human 24-hour periodicity journal June 1965
Design and Synthesis of Naphthalenic Dimers as Selective MT 1 Melatoninergic Ligands journal March 2003
The aging clock: circadian rhythms and later life journal February 2017
Cheetah : software for high-throughput reduction and analysis of serial femtosecond X-ray diffraction data journal May 2014

Similar Records

Pharmacology and function of melatonin receptors
Journal Article · Thu Sep 01 00:00:00 EDT 1988 · FASEB J.; (United States) · OSTI ID:6758413

Structural basis of ligand recognition at the human MT1 melatonin receptor
Journal Article · Tue Apr 23 20:00:00 EDT 2019 · Nature (London) · OSTI ID:1528824

Melatonin receptors: Current status, facts, and hypothesis
Journal Article · Sun Dec 31 23:00:00 EST 1989 · Life Sciences; (USA) · OSTI ID:6921837

Related Subjects