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(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2
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Enhanced Protein C Activation and Inhibition of Fibrinogen Cleavage by a Thrombin Modulator
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Structure–activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme
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Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity
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March 2017 |
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Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases
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November 2015 |
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Guidelines for accurate EC50/IC50 estimation
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March 2011 |
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Insulin-degrading enzyme regulates the levels of insulin, amyloid -protein, and the -amyloid precursor protein intracellular domain in vivo
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March 2003 |
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Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus
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January 2016 |
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Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis
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Data processing and analysis with the autoPROC toolbox
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PHENIX: a comprehensive Python-based system for macromolecular structure solution
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Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover
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January 2012 |
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A Monomeric Variant of Insulin Degrading Enzyme (IDE) Loses Its Regulatory Properties
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March 2010 |
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Neprilysin inhibition to treat heart failure: a tale of science, serendipity, and second chances: Neprilysin inhibition to treat heart failure
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March 2015 |
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Optimization of Peptide Hydroxamate Inhibitors of Insulin-Degrading Enzyme Reveals Marked Substrate-Selectivity
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March 2013 |
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Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin
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May 2010 |
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Phaser crystallographic software
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July 2007 |
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SHELXT – Integrated space-group and crystal-structure determination
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Enzyme target to latch on to
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USER fusion: a rapid and efficient method for simultaneous fusion and cloning of multiple PCR products
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Tanshinones that selectively block the collagenase activity of cathepsin K provide a novel class of ectosteric antiresorptive agents for bone: Ectosteric inhibitors of cathepsin K
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February 2018 |
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Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate
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December 2016 |
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Structure of Substrate-free Human Insulin-degrading Enzyme (IDE) and Biophysical Analysis of ATP-induced Conformational Switch of IDE
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July 2007 |
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Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice
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November 2018 |
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Methyl Effects on Protein–Ligand Binding
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April 2012 |
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OLEX2 : a complete structure solution, refinement and analysis program
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January 2009 |
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Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones
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May 2014 |
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Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo
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June 2015 |
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Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro
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March 2010 |
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Inhibition of MMP-2 gelatinolysis by targeting exodomain–substrate interactions
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July 2007 |
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Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors
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September 2015 |
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Insulin proteinase liberates from glucagon a fragment known to have enhanced activity against Ca2+ + Mg2+-dependent ATPase
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December 1988 |
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Insulin and Glucagon Degradation by the Same Enzyme
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Emerging principles in protease-based drug discovery
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SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A D isintegrin A nd M etalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes
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August 2015 |
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Coot model-building tools for molecular graphics
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November 2004 |
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Substrate Activation of Insulin-degrading Enzyme (Insulysin): A POTENTIAL TARGET FOR DRUG DEVELOPMENT
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October 2003 |
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Comparison of silver and molybdenum microfocus X-ray sources for single-crystal structure determination
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January 2015 |
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A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1
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December 2014 |
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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
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September 2015 |
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Crystal structure refinement with SHELXL
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Avoiding hypoglycemia: a key to success for glucose-lowering therapy in type 2 diabetes
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April 2013 |
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Fluorescence polarization assays in high-throughput screening and drug discovery: a review
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April 2016 |
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Purification and characterization of a rat liver cytosol neutral thiol peptidase that degrades glucagon, insulin, and isolated insulin A and B chains
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Insulin-Degrading Enzyme Inhibition, a Novel Therapy for Type 2 Diabetes?
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Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance
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June 2011 |
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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism
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October 2006 |
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Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme
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August 2013 |
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Substrate-Selective Inhibition of Protein Kinase PDK1 by Small Compounds that Bind to the PIF-Pocket Allosteric Docking Site
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September 2012 |
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Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin
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May 2008 |
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Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries
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Is there new hope for therapeutic matrix metalloproteinase inhibition?
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November 2014 |
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The Type 2 Diabetes-Associated Gene Ide Is Required for Insulin Secretion and Suppression of -Synuclein Levels in -Cells
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January 2013 |
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Degradation of Amylin by Insulin-degrading Enzyme
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HTRF: A Technology Tailored for Drug Discovery - A Review of Theoretical Aspects and Recent Applications
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Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †
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