Genomic Characterization of Newly Completed Genomes of Botulinum Neurotoxin-Producing Species from Argentina, Australia, and Africa

Smith, Theresa J.; Xie, Gary; Williamson, Charles H. D.; Hill, Karen K.; Fernández, Rafael A.; Sahl, Jason W.; Keim, Paul; Johnson, Shannon L.

doi:10.1093/gbe/evaa043

Title: Genomic Characterization of Newly Completed Genomes of Botulinum Neurotoxin-Producing Species from Argentina, Australia, and Africa

Journal Article · Mon Apr 06 00:00:00 EDT 2020 · Genome Biology and Evolution

DOI:https://doi.org/10.1093/gbe/evaa043· OSTI ID:1688743

Smith, Theresa J. ^[1];

^[2]; Williamson, Charles H. D. ^[1]; Hill, Karen K. ^[2]; Fernández, Rafael A. ^[3]; Sahl, Jason W. ^[1]; Keim, Paul ^[1];

^[2]

Northern Arizona Univ., Flagstaff, AZ (United States)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Univ. Nacional de Cuyo, Mendoza (Argentina)

Botulinum neurotoxin-producing clostridia are diverse in the types of toxins they produce as well as in their overall genomic composition. They are globally distributed, with prevalent species and toxin types found within distinct geographic regions, but related strains containing the same toxin types may also be located on distinct continents. The mechanisms behind the spread of these bacteria and the independent movements of their bont genes may be understood through examination of their genetic backgrounds. The generation of 15 complete genomic sequences from bacteria isolated in Argentina, Australia, and Africa allows for a thorough examination of genome features, including overall relationships, bont gene cluster locations and arrangements, and plasmid comparisons, in bacteria isolated from various areas in the southern hemisphere. Insights gained from these examinations provide an understanding of the mechanisms behind the independent movements of these elements among distinct species.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: US Department of Homeland Security (DHS)

Grant/Contract Number:: 89233218CNA000001; HSHQPM-15-X-00229

OSTI ID:: 1688743

Report Number(s):: LA-UR-19-26361

Journal Information:: Genome Biology and Evolution, Vol. 12, Issue 3; ISSN 1759-6653

Publisher:: Society for Molecular Biology and EvolutionCopyright Statement

Country of Publication:: United States

Language:: English

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