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Title: INEL BNCT Research Program annual report 1994

Abstract

This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1994. Contributions from the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (treatment planning software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of BSH and BPA is presented and results of 21 spontaneous tumor bearing dogs that have been treated with BNCT at Brookhaven National Laboratory (BNL) are discussed. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Highlights from the First International Workshop on Accelerator-Based Neutron Sources for BNCT are included. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.

Authors:
 [1]
  1. ed.
Publication Date:
Research Org.:
Lockheed Idaho Technologies Co., Idaho Falls, ID (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
168379
Report Number(s):
INEL-95/0561
ON: DE96003995; TRN: 96:003202
DOE Contract Number:
AC07-94ID13223
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: Nov 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; NEUTRON CAPTURE THERAPY; RADIOBIOLOGY; NUCLEAR MEDICINE; BORON 10; LEADING ABSTRACT; LIPOPROTEINS; LIPOSOMES; NEOPLASMS; RADIOPHARMACEUTICALS; NEUTRON DOSIMETRY; NEUTRON SOURCES; IMAGE PROCESSING; PROGRESS REPORT

Citation Formats

Venhuizen, J.R.. INEL BNCT Research Program annual report 1994. United States: N. p., 1995. Web. doi:10.2172/168379.
Venhuizen, J.R.. INEL BNCT Research Program annual report 1994. United States. doi:10.2172/168379.
Venhuizen, J.R.. Wed . "INEL BNCT Research Program annual report 1994". United States. doi:10.2172/168379. https://www.osti.gov/servlets/purl/168379.
@article{osti_168379,
title = {INEL BNCT Research Program annual report 1994},
author = {Venhuizen, J.R.},
abstractNote = {This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1994. Contributions from the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (treatment planning software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of BSH and BPA is presented and results of 21 spontaneous tumor bearing dogs that have been treated with BNCT at Brookhaven National Laboratory (BNL) are discussed. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Highlights from the First International Workshop on Accelerator-Based Neutron Sources for BNCT are included. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.},
doi = {10.2172/168379},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Nov 01 00:00:00 EST 1995},
month = {Wed Nov 01 00:00:00 EST 1995}
}

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