Production, Collection, and Purification of 47 Ca for the Generation of 47 Sc through Isotope Harvesting at the National Superconducting Cyclotron Laboratory

Abel, E. Paige; Domnanich, Katharina; Clause, Hannah K.; Kalman, Colton; Walker, Wes; Shusterman, Jennifer A.; Greene, John; Gott, Matthew; Severin, Gregory W.

doi:10.1021/acsomega.0c03020

Title: Production, Collection, and Purification of ⁴⁷ Ca for the Generation of ⁴⁷ Sc through Isotope Harvesting at the National Superconducting Cyclotron Laboratory

Journal Article · Thu Oct 22 00:00:00 EDT 2020 · ACS Omega

DOI:https://doi.org/10.1021/acsomega.0c03020· OSTI ID:1682510

Abel, E. Paige ^[1]; Domnanich, Katharina ^[1]; Clause, Hannah K. ^[1]; Kalman, Colton ^[2]; Walker, Wes ^[2]; Shusterman, Jennifer A. ^[3]; Greene, John ^[4]; Gott, Matthew ^[4];

^[1]

Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States, National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, United States
National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824, United States
Department of Chemistry, Hunter College of the City University of New York, New York, New York 10065, United States, Ph. D. Program in Chemistry, The Graduate Center of the City of New York, New York, New York 10016, United States
Physics Division, Argonne National Laboratory, Lemont, Illinois 60439, United States

An experiment was performed at the National Superconducting Cyclotron Laboratory using a 140 MeV/nucleon 48Ca beam and a flowing-water target to produce 47Ca for the first time with this production route. A production rate of 0.020 ± 0.004 47Ca per incoming beam particle was measured. An isotope harvesting system attached to the target was used to collect radioactive cationic products, including 47Ca, from the water on a cation exchange resin. The 47Ca collected was purified using three separation methods optimized for this work: 1) DGA resin with HNO3 and HCl, 2) AG MP-50 cation exchange resin with an increasing concentration gradient of HCl, and 3) AG MP-50 resin with a methanolic HCl gradient. These methods resulted in ≥99 ± 2% separation yield of 47Ca with 100% radionuclidic purity within the limits of detection for HPGe measurements. ICP-OES was used to identify low levels of stable ions in the water of the isotope harvesting system during the irradiation and in the final purified solution of 47Ca. For the first time, this experiment demonstrated the feasibility of production, collection, and purification of 47Ca through isotope harvesting for the generation of 47Sc for nuclear medicine applications.

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Research Organization:: Michigan State Univ., East Lansing, MI (United States); Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP); USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC02-06CH11357; SC0018637; NA0003864

OSTI ID:: 1682510

Alternate ID(s):: OSTI ID: 1699394; OSTI ID: 1762262

Journal Information:: ACS Omega, Journal Name: ACS Omega Vol. 5 Journal Issue: 43; ISSN 2470-1343

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

References (40)

Electron linear accelerator production and purification of scandium-47 from titanium dioxide targets Rotsch, David A.; Brown, M. Alex; Nolen, Jerry A. Applied Radiation and Isotopes, Vol. 131 https://doi.org/10.1016/j.apradiso.2017.11.007	journal	January 2018
Nuclear Data Sheets for A = 27 Shamsuzzoha Basunia, M. Nuclear Data Sheets, Vol. 112, Issue 8 https://doi.org/10.1016/j.nds.2011.08.001	journal	August 2011
Influence of diluent on radiolysis of amides in organic solution Sugo, Yumi; Izumi, Yoshinobu; Yoshida, Yoichi Radiation Physics and Chemistry, Vol. 76, Issue 5 https://doi.org/10.1016/j.radphyschem.2006.05.008	journal	May 2007
Accelerator-based photoproduction of promising beta-emitters 67Cu and 47Sc Starovoitova, Valeriia N.; Cole, Philip L.; Grimm, Terry L. Journal of Radioanalytical and Nuclear Chemistry, Vol. 305, Issue 1 https://doi.org/10.1007/s10967-015-4039-z	journal	March 2015
Clinical Translation and First In-Human Use of [ ⁴⁴ Sc]Sc-PSMA-617 for PET Imaging of Metastasized Castrate-Resistant Prostate Cancer Eppard, Elisabeth; de la Fuente, Ana; Benešová, Martina Theranostics, Vol. 7, Issue 18 https://doi.org/10.7150/thno.20586	journal	January 2017
Cyclotron production of 44Sc: From bench to bedside van der Meulen, Nicholas P.; Bunka, Maruta; Domnanich, Katharina A. Nuclear Medicine and Biology, Vol. 42, Issue 9 https://doi.org/10.1016/j.nucmedbio.2015.05.005	journal	September 2015
Nuclear Data Sheets for A = 24 Firestone, R. B. Nuclear Data Sheets, Vol. 108, Issue 11 https://doi.org/10.1016/j.nds.2007.10.001	journal	November 2007
Production and separation of 43Sc for radiopharmaceutical purposes Domnanich, Katharina A.; Eichler, Robert; Müller, Cristina EJNMMI Radiopharmacy and Chemistry, Vol. 2, Issue 1 https://doi.org/10.1186/s41181-017-0033-9	journal	November 2017
Therapeutic Potential of 47Sc in Comparison to 177Lu and 90Y: Preclinical Investigations Siwowska, Klaudia; Guzik, Patrycja; Domnanich, Katharina A. Pharmaceutics, Vol. 11, Issue 8 https://doi.org/10.3390/pharmaceutics11080424	journal	August 2019
Nuclear Data Sheets for A = 28 Shamsuzzoha Basunia, M. Nuclear Data Sheets, Vol. 114, Issue 10 https://doi.org/10.1016/j.nds.2013.10.001	journal	October 2013
Promising Prospects for 44Sc-/47Sc-Based Theragnostics: Application of 47Sc for Radionuclide Tumor Therapy in Mice Muller, C.; Bunka, M.; Haller, S. Journal of Nuclear Medicine, Vol. 55, Issue 10 https://doi.org/10.2967/jnumed.114.141614	journal	July 2014
Isotope harvesting at FRIB: additional opportunities for scientific discovery Abel, E. Paige; Avilov, Mikael; Ayres, Virginia Journal of Physics G: Nuclear and Particle Physics, Vol. 46, Issue 10 https://doi.org/10.1088/1361-6471/ab26cc	journal	August 2019
Scandium and terbium radionuclides for radiotheranostics: current state of development towards clinical application Müller, Cristina; Domnanich, Katharina A.; Umbricht, Christoph A. The British Journal of Radiology, Vol. 91, Issue 1091 https://doi.org/10.1259/bjr.20180074	journal	November 2018
Thermal, mechanical and fluid flow aspects of the high power beam dump for FRIB Avilov, Mikhail; Aaron, Adam; Amroussia, Aida Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 376 https://doi.org/10.1016/j.nimb.2016.02.068	journal	June 2016
47Sc production development by cyclotron irradiation of 48Ca Misiak, R.; Walczak, R.; Wąs, B. Journal of Radioanalytical and Nuclear Chemistry, Vol. 313, Issue 2 https://doi.org/10.1007/s10967-017-5321-z	journal	June 2017
Sc-47 production from titanium targets using electron linacs Mamtimin, Mayir; Harmon, Frank; Starovoitova, Valeriia N. Applied Radiation and Isotopes, Vol. 102 https://doi.org/10.1016/j.apradiso.2015.04.012	journal	August 2015
Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47Sc Loveless, C. Shaun; Radford, Lauren L.; Ferran, Samuel J. EJNMMI Research, Vol. 9, Issue 1 https://doi.org/10.1186/s13550-019-0515-8	journal	May 2019
LISE++: Radioactive beam production with in-flight separators Tarasov, O. B.; Bazin, D. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 266, Issue 19-20 https://doi.org/10.1016/j.nimb.2008.05.110	journal	October 2008
Preparation of carrier-free 47Sc by the 48Ti (γ,p) reaction Yagi, Masuo; Kondo, Kenjiro The International Journal of Applied Radiation and Isotopes, Vol. 28, Issue 5 https://doi.org/10.1016/0020-708X(77)90178-8	journal	May 1977
First-in-Human PET/CT Imaging of Metastatic Neuroendocrine Neoplasms with Cyclotron-Produced ⁴⁴ Sc-DOTATOC: A Proof-of-Concept Study Singh, Aviral; van der Meulen, Nicholas P.; Müller, Cristina Cancer Biotherapy and Radiopharmaceuticals, Vol. 32, Issue 4 https://doi.org/10.1089/cbr.2016.2173	journal	May 2017
Nuclear Data Sheets for A = 43 Singh, Balraj; Chen, Jun Nuclear Data Sheets, Vol. 126 https://doi.org/10.1016/j.nds.2015.05.001	journal	May 2015
47Sc as useful β–-emitter for the radiotheragnostic paradigm: a comparative study of feasible production routes Domnanich, Katharina A.; Müller, Cristina; Benešová, Martina EJNMMI Radiopharmacy and Chemistry, Vol. 2, Issue 1 https://doi.org/10.1186/s41181-017-0024-x	journal	June 2017
Design and construction of a water target system for harvesting radioisotopes at the National Superconducting Cyclotron Laboratory Pen, Aranh; Mastren, Tara; Peaslee, Graham F. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 747 https://doi.org/10.1016/j.nima.2014.02.010	journal	May 2014
Need satisfaction and the self-regulation of learning Deci, Edward L.; Ryan, Richard M.; Williams, Geoffrey C. Learning and Individual Differences, Vol. 8, Issue 3 https://doi.org/10.1016/S1041-6080(96)90013-8	journal	January 1996
Promises of Cyclotron-Produced 44Sc as a Diagnostic Match for Trivalent --Emitters: In Vitro and In Vivo Study of a 44Sc-DOTA-Folate Conjugate Muller, C.; Bunka, M.; Reber, J. Journal of Nuclear Medicine, Vol. 54, Issue 12 https://doi.org/10.2967/jnumed.113.123810	journal	November 2013
Production and purification of Scandium-47: A potential radioisotope for cancer theranostics Deilami-nezhad, Leila; Moghaddam-Banaem, Leila; Sadeghi, Mahdi Applied Radiation and Isotopes, Vol. 118 https://doi.org/10.1016/j.apradiso.2016.09.004	journal	December 2016
Nuclear Data Sheets for A = 48 Burrows, T. W. Nuclear Data Sheets, Vol. 107, Issue 7 https://doi.org/10.1016/j.nds.2006.05.005	journal	July 2006
Nuclear Data Sheets for A = 42 Singh, Balraj; Cameron, John A. Nuclear Data Sheets, Vol. 92, Issue 1 https://doi.org/10.1006/ndsh.2001.0001	journal	January 2001
Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: 67Cu Mastren, Tara; Pen, Aranh; Peaslee, Graham F. Scientific Reports, Vol. 4, Issue 1 https://doi.org/10.1038/srep06706	journal	October 2014
An isotope harvesting beam blocker for the National Superconducting Cyclotron Laboratory Domnanich, Katharina A.; Abel, E. Paige; Clause, Hannah K. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 959 https://doi.org/10.1016/j.nima.2020.163526	journal	April 2020
Nuclear Data Sheets for A = 45 Burrows, T. W. Nuclear Data Sheets, Vol. 109, Issue 1 https://doi.org/10.1016/j.nds.2007.12.002	journal	January 2008
47Ca production for 47Ca/47Sc generator system using electron linacs Rane, Shraddha; Harris, Jason T.; Starovoitova, Valeriia N. Applied Radiation and Isotopes, Vol. 97 https://doi.org/10.1016/j.apradiso.2014.12.020	journal	March 2015
Harvesting 48V at the National Superconducting Cyclotron Laboratory Loveless, C. Shaun; Marois, Boone E.; Ferran, Samuel J. Applied Radiation and Isotopes, Vol. 157 https://doi.org/10.1016/j.apradiso.2019.109023	journal	March 2020
Nuclear Data Sheets for A = 47 Burrows, T. W. Nuclear Data Sheets, Vol. 108, Issue 5 https://doi.org/10.1016/j.nds.2007.04.002	journal	May 2007
Harvesting ⁶⁷ Cu from the Collection of a Secondary Beam Cocktail at the National Superconducting Cyclotron Laboratory Mastren, Tara; Pen, Aranh; Loveless, Shaun Analytical Chemistry, Vol. 87, Issue 20 https://doi.org/10.1021/acs.analchem.5b02322	journal	October 2015
Novel Extraction of Chromatographic Resins Based on Tetraalkyldiglycolamides: Characterization and Potential Applications Horwitz, E. P.; McAlister, D. R.; Bond, A. H. Solvent Extraction and Ion Exchange, Vol. 23, Issue 3 https://doi.org/10.1081/SEI-200049898	journal	May 2005
Radiolysis and radionuclide production in a flowing-water target during fast 40Ca20+ irradiation. Abel, E. Paige; Clause, Hannah K.; Severin, Gregory W. Applied Radiation and Isotopes, Vol. 158 https://doi.org/10.1016/j.apradiso.2020.109049	journal	April 2020
Features of Particle and Heavy Ion Transport code System (PHITS) version 3.02 Sato, Tatsuhiko; Iwamoto, Yosuke; Hashimoto, Shintaro Journal of Nuclear Science and Technology, Vol. 55, Issue 6 https://doi.org/10.1080/00223131.2017.1419890	journal	January 2018
Nuclear Data Sheets for A = 44 Chen, Jun; Singh, Balraj; Cameron, John A. Nuclear Data Sheets, Vol. 112, Issue 9 https://doi.org/10.1016/j.nds.2011.08.005	journal	September 2011
Nuclear Data Sheets Update for A = 46 Peker, L. K. Nuclear Data Sheets, Vol. 68, Issue 2 https://doi.org/10.1006/ndsh.1993.1009	journal	February 1993

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