The canonical frameworks of viral evolution describe viruses as cellular predecessors, reduced forms of cells, or entities that escaped cellular control. The discovery of giant viruses has changed these standard paradigms. Their genetic, proteomic and structural complexities resemble those of cells, prompting a redefinition and reclassification of viruses. In a previous genome-wide analysis of the evolution of structural domains in proteomes, with domains defined at the fold superfamily level, we found the origins of viruses intertwined with those of ancient cells. In this review, we extend these data-driven analyses to the study of fold families confirming the co-evolution of viruses and ancient cells and the genetic ability of viruses to foster molecular innovation. The results support our suggestion that viruses arose by genomic reduction from ancient cells and validate a co-evolutionary ‘symbiogenic’ model of viral origins.
Mughal, Fizza, et al. "The origin and evolution of viruses inferred from fold family structure." Archives of Virology, vol. 165, no. 10, Aug. 2020. https://doi.org/10.1007/s00705-020-04724-1
Mughal, Fizza, Nasir, Arshan, & Caetano-Anollés, Gustavo (2020). The origin and evolution of viruses inferred from fold family structure. Archives of Virology, 165(10). https://doi.org/10.1007/s00705-020-04724-1
Mughal, Fizza, Nasir, Arshan, and Caetano-Anollés, Gustavo, "The origin and evolution of viruses inferred from fold family structure," Archives of Virology 165, no. 10 (2020), https://doi.org/10.1007/s00705-020-04724-1
@article{osti_1680022,
author = {Mughal, Fizza and Nasir, Arshan and Caetano-Anollés, Gustavo},
title = {The origin and evolution of viruses inferred from fold family structure},
annote = {The canonical frameworks of viral evolution describe viruses as cellular predecessors, reduced forms of cells, or entities that escaped cellular control. The discovery of giant viruses has changed these standard paradigms. Their genetic, proteomic and structural complexities resemble those of cells, prompting a redefinition and reclassification of viruses. In a previous genome-wide analysis of the evolution of structural domains in proteomes, with domains defined at the fold superfamily level, we found the origins of viruses intertwined with those of ancient cells. In this review, we extend these data-driven analyses to the study of fold families confirming the co-evolution of viruses and ancient cells and the genetic ability of viruses to foster molecular innovation. The results support our suggestion that viruses arose by genomic reduction from ancient cells and validate a co-evolutionary ‘symbiogenic’ model of viral origins.},
doi = {10.1007/s00705-020-04724-1},
url = {https://www.osti.gov/biblio/1680022},
journal = {Archives of Virology},
issn = {ISSN 0304-8608},
number = {10},
volume = {165},
place = {United States},
publisher = {Springer Nature},
year = {2020},
month = {08}}
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
National Science Foundation (NSF); USDA; USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE National Nuclear Security Administration (NNSA)
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