COVID-19 Infection Prevention through Natural Product Molecules
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
This project evaluates natural product molecules with the potential to prevent 2019- nCOV infection. The molecules theoretically work by blocking the ACE2 protein active site in human airways. Previous work focused on modeling candidate natural compounds, but this work examined baicalin, hesperetin, glycyrrhizin, and scutellarin in experimental in vitro studies, which included recombinant protein inhibition assays, cell culture virus inhibition assays, and cytotoxicity assays. The project delivered selectivity indices (ratio that measures the window between cytotoxicity and antiviral activity) of the four natural compounds that will help guide the direction of SARS-CoV-2 therapeutic development.
- Research Organization:
- Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Sandia National Laboratories, Livermore, CA
- Sponsoring Organization:
- USDOE National Nuclear Security Administration (NNSA)
- DOE Contract Number:
- AC04-94AL85000; NA0003525
- OSTI ID:
- 1678839
- Report Number(s):
- SAND--2020-10857; 691520
- Country of Publication:
- United States
- Language:
- English
Similar Records
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice
Deactivation of SARS-CoV-2 by Boronic Acid-Functionalized Polymer