Characterization of Local and Systemic Impact of Whitefly (Bemisia tabaci) Feeding and Whitefly-Transmitted Tomato Mottle Virus Infection on Tomato Leaves by Comprehensive Proteomics

Ogden, Aaron J.; Boukari, Wardatou; Nava, Alba; Lucinda, Natalia; Sunter, Garry; Curtis, Wayne R.; Adkins, Joshua N.; Polston, Jane E.

doi:10.3390/ijms21197241

Title: Characterization of Local and Systemic Impact of Whitefly (Bemisia tabaci) Feeding and Whitefly-Transmitted Tomato Mottle Virus Infection on Tomato Leaves by Comprehensive Proteomics

Journal Article · Wed Sep 30 00:00:00 EDT 2020 · International Journal of Molecular Sciences (Online)

DOI:https://doi.org/10.3390/ijms21197241· OSTI ID:1674962

^[1]; Boukari, Wardatou ^[2]; Nava, Alba ^[3]; Lucinda, Natalia ^[3]; Sunter, Garry ^[3]; Curtis, Wayne R. ^[4];

^[1]; Polston, Jane E. ^[2]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Univ. of Florida, Gainesville, FL (United States)
Univ. of Texas at San Antonio, TX (United States)
Pennsylvania State Univ., University Park, PA (United States)

Tomato mottle virus (ToMoV) is a ssDNA plant begomovirus transmitted to solanaceous crops by the whitefly species complex (Bemisia tabaci), causing stunted growth, leaf mottling, and reduced fruit yield. Using a genetic repertoire of 7 genes, ToMoV pathogenesis includes manipulation of multiple plant biological processes to circumvent antiviral defenses. To further understand the effects of whitefly feeding and whitefly-transmitted ToMoV infection on tomato plants (Solanum lycopersicum ‘Florida Lanai’), we generated comprehensive protein profiles of leaves subjected to feeding by either (1) viruliferous whiteflies harboring ToMoV, or (2) non-viruliferous whiteflies, or (3) a no-feeding control. In each condition (1-3), whiteflies were confined to clip cages on a mature leaf for 3 days. The effects of whitefly feeding and ToMoV infection were measured both locally and systemically by sampling either a mature leaf directly from the site of whitefly feeding, or from a newly formed leaf 10 days post feeding (dpf). At 3 dpf, relatively few biological processes were affected specifically by ToMoV at the site of feeding, and include proteins associated with translation initiation and elongation, and plasmodesmata dynamics. In contrast, the systemic impacts of ToMoV on younger leaves at 10 dpf were more pronounced and included a virus-specific change in plant proteins associated with mRNA maturation and export, RNA-dependent DNA methylation, and other plant anti-viral transcriptional gene silencing systems. Our analysis supports previous findings and provides novel insight into biological processes in tomato altered locally and systemically by whitefly feeding and ToMoV infection.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); Defense Advanced Research Projects Agency (DARPA); USDOD

Grant/Contract Number:: AC05-76RL01830; HR0011-17-2-0055

OSTI ID:: 1674962

Report Number(s):: PNNL-SA-153927

Journal Information:: International Journal of Molecular Sciences (Online), Vol. 21, Issue 19

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Assessing Global Transcriptome Changes in Response to South African Cassava Mosaic Virus [ZA-99] Infection in Susceptible Arabidopsis thaliana Pierce, Erica J.; Rey, M. E. Chrissie PLoS ONE, Vol. 8, Issue 6 https://doi.org/10.1371/journal.pone.0067534	journal	June 2013
Geminivirus AL2 and L2 Proteins Interact with and Inactivate SNF1 Kinase Hao, Linhui; Wang, Hui; Sunter, Garry The Plant Cell, Vol. 15, Issue 4 https://doi.org/10.1105/tpc.009530	journal	March 2003
The RNA Export Factor ALY1 Enables Genome-Wide RNA-Directed DNA Methylation Choudury, Sarah G.; Shahid, Saima; Cuerda-Gil, Diego The Plant Cell, Vol. 31, Issue 4 https://doi.org/10.1105/tpc.18.00624	journal	February 2019
Dynamic Distribution and Interaction of the Arabidopsis SRSF1 Subfamily Splicing Factors Stankovic, Nancy; Schloesser, Marie; Joris, Marine Plant Physiology, Vol. 170, Issue 2 https://doi.org/10.1104/pp.15.01338	journal	December 2015

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59 BASIC BIOLOGICAL SCIENCES
tomato
tomato mottle virus
RNA directed DNA methylation
transcriptional gene silencing
Begomovirus
Geminivirus
Bemisia tabaci
whitefly
pathogenesis
proteomics

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