Dermal absorption of neat and aqueous volatile organic chemicals in the Fischer 344 rat. (Reannouncement with new availability information). Final report, July 1986-December 1990

Technical Report · Tue Dec 31 04:00:00 EST 1991

OSTI ID:166877

Morgan, D L; Cooper, S W; Carlock, D L; Sykora, J J; Sutton, B

Quantification of dermal absorption of volatile organic chemicals (VOCs) from aqueous solutions is required to understand the potential health hazards resulting from skin exposure to these chemicals in contaminated water. Male Fischer 344 rats were dermally exposed to neat, one-third saturated, two-thirds saturated, or saturated aqueous solutions of 14 VOCs for 24 hr. Blood samples were obtained via indwelling jugular catheters during exposure and analyzed for the VOCs by gas chromatography using headspace analysis. Absorption of the neat VOCs in this series of chemicals decreased as water solubility decreased. Peak blood levels of VOCs attained during exposure for 24 hr to neat chemical were: 1,2-dichloroethane, bromochloromethane, chloroform, benzene, tetrachloroethylene, dibromomethane, trichloroethylene, toluene, xylene, hexane, ethylbenzene, styrene, carbon tetrachloride, and 1,1,1-trichloroethane. Blood levels of 1,2-dichloroethane and benzene continued to increase during the 24-hr exposure to neat chemical, while blood levels of 1,2-dichloroethane and benzene continued to increase during the 24 hr exposure to neat chemical, while blood levels of the other neat VOCs peaked within 4 hr and then either decreased or remained about the same for the duration of the exposure. Absorption of VOCs from one-third, two-thirds, or saturated aqueous solutions was rapid, and resulted in depletion of the chemical from the solution although only a small amount of water was absorbed. Blood levels of each VOC were directly related to the exposure concentrations.

• Research Organization: ManTech Environmental Technology, Inc., Dayton, OH (United States)
• OSTI ID: 166877
• Report Number(s): AD-A--252169/8/XAB; CNN: Contract F33615-90-C-0532
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
AQUEOUS SOLUTIONS
AROMATICS
BENZENE
CARBON TETRACHLORIDE
ETHYLENE
HEALTH HAZARDS
HEXANE
PROGRESS REPORT
STYRENE
TOLUENE
TOXICITY
XYLENES