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Omics-Lethal Human Viruses, MERS-CoV Experiment MCL003

Dataset ·
 [1];  [2];  [3]
  1. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Pacific Northwest National Laboratory, Biological Sciences Division
  2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
  3. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
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The purpose of this experiment was to evaluate the human host response to wild-type icMERS-CoV virus infection and mockulum. Sample data was obtained from human lung adenocarcinoma cells (Calu-3) for proteome, metabolome, and lipidome expression analysis. Resulting quantitative data profiles were evaluated for extreme outlier behavior using MPLEX protocol. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, and lipidomics dataset download each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.
Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
Contributing Organization:
Modeling Host Responses to Understand Severe Human Virus Infections Program Project
DOE Contract Number:
AC05-76RL01830
OSTI ID:
1661945
Report Number(s):
MCL003; MassIVE: MSV000079152 (proteome); ​​​​​​​MassIVE: MSV000080022 (metabolome); MassIVE: MSV000079154 (lipidome)
Availability:
rc-support@pnnl.gov
Country of Publication:
United States
Language:
English

References (1)

MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses journal May 2016

Cited By (1)

Omics Lethal Human Viruses Project Profiling of the Host Response to MERS-CoV Infection, Processed Experimental Dataset Catalog dataset January 2021

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Data Download [schema:DataDownload]
Human virus [NCIT:C14317]
Immune Response [GO:0006955]
Mass spectrometry data [edam.data:2536]
MassIVE dataset identifier [MS:1002487]
Middle East respiratory syndrome-related coronavirus [NCBITAXON:1335626]
Multi-omics [edam.topic:4021]
Omics [edam.topic:3391]
Time Sampled Measurement Datasets [IAO:0000584]
Virology [edam.topic:0781]
data transformation [SIO:000594]
differential expression analysis [SWO:7000018]