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Omics-Lethal Human Viruses, Ebola Experiment EHUH001

Dataset ·
 [1];  [2];  [3]
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Pacific Northwest National Laboratory, Biological Sciences Division
  2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
  3. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
+ Show Author Affiliations

The purpose of this experiment was to evaluate the human host response to Zaire Ebola wild-type virus and mutant virus infection. Samples were obtained from human hepatoma carcinoma cells (HUH-7) infected with Zaire Ebola ΔVP30-WT background, in addition to mutant viruses Ebola-ΔsGP (eliminating expression of soluble glycoprotein ssGP) and Ebola-Δmucin (encoding a glycoprotein lacking the mucin domain) for mRNA and miRNA transcriptome expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset downloads have a direct relationship to a primary sample submission corresponding to a specific Ebola virus infection.

Research Organization:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
Contributing Organization:
Modeling Host Responses to Understand Severe Human Virus Infections Program Project
DOE Contract Number:
AC05-76RL01830
OSTI ID:
1661905
Report Number(s):
EHUH001; NCBI BioProject: PRJNA317724 (mRNA); NCBI BioProject: PRJNA317723 (miRNA); GEO Series: GSE80058 (mRNA); GEO Series: GSE80059 (miRNA)
Availability:
rc-support@pnnl.gov
Country of Publication:
United States
Language:
English

References (1)

Hypergraph models of biological networks to identify genes critical to pathogenic viral response journal May 2021

Cited By (1)

PNNL DataHub Project Omics-LHV Profiling of Host Response to Ebola Infection Post-Processed Data Package DOIs dataset January 2021

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BioProject Accession Number [NCIT:C175890]
Data Download [schema:DataDownload]
Ebola virus [NCBITAXON:186536]
Gene expression profile data [edam.data:0928]
Human virus [NCIT:C14317]
Immune Response [GO:0006955]
Omics [edam.topic:3391]
Time Sampled Measurement Datasets [IAO:0000584]
Virology [edam.topic:0781]
data transformation [SIO:000594]
differential expression analysis [SWO:7000018]