Silica Nanodepletors: Targeting and Clearing Alzheimer's beta-Amyloid Plaques

Jung, Huijin; Chung, You Jung; Wilton, Rosemarie; Lee, Chang Heon; Lee, Byung Il; Lim, Jinyeong; Lee, Hyojin; Choi, Jong-Ho; Kang, Hyuno; Lee, Byeongdu; Rozhkova, Elena A.; Park, Chan Beum; Lee, Joonseok

doi:10.1002/adfm.201910475

Silica Nanodepletors: Targeting and Clearing Alzheimer's beta-Amyloid Plaques

Journal Article · Wed Apr 01 04:00:00 EDT 2020 · Advanced Functional Materials (Online)

DOI:https://doi.org/10.1002/adfm.201910475· OSTI ID:1660950

Jung, Huijin; Chung, You Jung; Wilton, Rosemarie; Lee, Chang Heon; Lee, Byung Il; Lim, Jinyeong; Lee, Hyojin; Choi, Jong-Ho; Kang, Hyuno; Lee, Byeongdu; Rozhkova, Elena A.; Park, Chan Beum; Lee, Joonseok

Abnormal accumulation of beta-amyloid (A beta) peptide aggregates in the brain is a major hallmark of Alzheimer's disease (AD). A beta aggregates interfere with neuronal communications, ultimately causing neuronal damage and brain atrophy. Much effort has been made to develop AD treatments that suppress A beta aggregate formation, thereby attenuating A beta-induced neurotoxicity. Here, the design of A beta nanodepletors consisting of ultralarge mesoporous silica nanostructures and anti-A beta single-chain variable fragments, with the goal of targeting and eliminating aggregative A beta monomers, is reported. The A beta nanodepletors impart a notable decline in A beta aggregate formation, resulting in significant mitigation of A beta-induced neurotoxicity in vitro. Furthermore, stereotaxic injections of A beta nanodepletors into the brain of an AD mouse model system successfully suppress A beta plaque formation in vivo up to approximate to 30%, suggesting that A beta nanodepletors can serve as a promising antiamylodoisis material.

Research Organization:: Argonne National Laboratory (ANL)

Sponsoring Organization:: Korea Institute of Science and Technology (KIST); National Research Foundation (NRF) of Korea; USDOE Office of Science - Office of Basic Energy Sciences

DOE Contract Number:: AC02-06CH11357

OSTI ID:: 1660950

Journal Information:: Advanced Functional Materials (Online), Journal Name: Advanced Functional Materials (Online) Journal Issue: 15 Vol. 30; ISSN 1616-3028

Country of Publication:: United States

Language:: English

References (48)

Recent Advances in Anti-cancer Protein/Peptide Delivery Liu, Xun; Wu, Fan; Ji, Yong Bioconjugate Chemistry, Vol. 30, Issue 2 https://doi.org/10.1021/acs.bioconjchem.8b00750	journal	November 2018
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability Niesen, Frank H.; Berglund, Helena; Vedadi, Masoud Nature Protocols, Vol. 2, Issue 9 https://doi.org/10.1038/nprot.2007.321	journal	September 2007
Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo Yang, Fusheng; Lim, Giselle P.; Begum, Aynun N. Journal of Biological Chemistry, Vol. 280, Issue 7 https://doi.org/10.1074/jbc.M404751200	journal	December 2004
Molecular mechanism of Thioflavin-T binding to amyloid fibrils Biancalana, Matthew; Koide, Shohei Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1804, Issue 7 https://doi.org/10.1016/j.bbapap.2010.04.001	journal	July 2010
Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Sperling, Reisa A.; Aisen, Paul S.; Beckett, Laurel A. Alzheimer's & Dementia, Vol. 7, Issue 3 https://doi.org/10.1016/j.jalz.2011.03.003	journal	May 2011
Rapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-β Lim, Yen Ying; Pietrzak, Robert H.; Ellis, Kathryn A. Journal of Alzheimer's Disease, Vol. 33, Issue 3 https://doi.org/10.3233/JAD-2012-121516	journal	January 2013
Moving towards early clinical trials for amyloid-targeted therapy in Alzheimer's disease Aisen, Paul S.; Vellas, Bruno; Hampel, Harald Nature Reviews Drug Discovery, Vol. 12, Issue 4 https://doi.org/10.1038/nrd3842-c1	journal	March 2013
Silica-based nanoparticles for biomedical applications Bitar, Ahmad; Ahmad, Nasir M.; Fessi, Hatem Drug Discovery Today, Vol. 17, Issue 19-20 https://doi.org/10.1016/j.drudis.2012.06.014	journal	October 2012
Peptide Aggregation in Neurodegenerative Disease Murphy, Regina M. Annual Review of Biomedical Engineering, Vol. 4, Issue 1 https://doi.org/10.1146/annurev.bioeng.4.092801.094202	journal	August 2002
Molecular Variations in Aromatic Cosolutes: Critical Role in the Rheology of Cationic Wormlike Micelles Ito, Thiago H.; Miranda, Paulo C. M. L.; Morgon, Nelson H. Langmuir, Vol. 30, Issue 39 https://doi.org/10.1021/la502649j	journal	September 2014
A century-old debate on protein aggregation and neurodegeneration enters the clinic Lansbury, Peter T.; Lashuel, Hilal A. Nature, Vol. 443, Issue 7113 https://doi.org/10.1038/nature05290	journal	October 2006
Self-Assembling Peptides as Building Blocks of Functional Materials for Biomedical Applications Fukunaga, Kazuto; Tsutsumi, Hiroshi; Mihara, Hisakazu Bulletin of the Chemical Society of Japan, Vol. 92, Issue 2 https://doi.org/10.1246/bcsj.20180293	journal	February 2019
Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils Bieschke, Jan; Herbst, Martin; Wiglenda, Thomas Nature Chemical Biology, Vol. 8, Issue 1 https://doi.org/10.1038/nchembio.719	journal	November 2011
Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system for the attachment of biotinylated molecules in vitro and in vivo van der Meer, Selina Beatrice; Knuschke, Torben; Frede, Annika Acta Biomaterialia, Vol. 57 https://doi.org/10.1016/j.actbio.2017.05.049	journal	July 2017
Engineered antibody fragments and the rise of single domains Holliger, Philipp; Hudson, Peter J. Nature Biotechnology, Vol. 23, Issue 9 https://doi.org/10.1038/nbt1142	journal	September 2005
Impact of multiple pathologies on the threshold for clinically overt dementia Kapasi, Alifiya; DeCarli, Charles; Schneider, Julie A. Acta Neuropathologica, Vol. 134, Issue 2 https://doi.org/10.1007/s00401-017-1717-7	journal	May 2017
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study Villemagne, Victor L.; Burnham, Samantha; Bourgeat, Pierrick The Lancet Neurology, Vol. 12, Issue 4 https://doi.org/10.1016/S1474-4422(13)70044-9	journal	April 2013
Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase Maurin, Hervé; Lechat, Benoit; Dewachter, Ilse Molecular Brain, Vol. 6, Issue 1 https://doi.org/10.1186/1756-6606-6-27	journal	January 2013
A self-destructive nanosweeper that captures and clears amyloid β-peptides Luo, Qiang; Lin, Yao-Xin; Yang, Pei-Pei Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04255-z	journal	May 2018
B6 Peptide-Modified PEG-PLA Nanoparticles for Enhanced Brain Delivery of Neuroprotective Peptide Liu, Zhongyang; Gao, Xiaoling; Kang, Ting Bioconjugate Chemistry, Vol. 24, Issue 6 https://doi.org/10.1021/bc400055h	journal	June 2013
Protein aggregation and neurodegenerative disease Ross, Christopher A.; Poirier, Michelle A. Nature Medicine, Vol. 10, Issue S7 https://doi.org/10.1038/nm1066	journal	July 2004
Combinatorial drug therapy for cancer in the post-genomic era Al-Lazikani, Bissan; Banerji, Udai; Workman, Paul Nature Biotechnology, Vol. 30, Issue 7 https://doi.org/10.1038/nbt.2284	journal	July 2012
Self-Assembling Peptide-Based Nanoarchitectonics Zhao, Luyang; Zou, Qianli; Yan, Xuehai Bulletin of the Chemical Society of Japan, Vol. 92, Issue 1 https://doi.org/10.1246/bcsj.20180248	journal	January 2019
Asymmetric Hybrid Silica Nanomotors for Capture and Cargo Transport: Towards a Novel Motion-Based DNA Sensor Simmchen, Juliane; Baeza, Alejandro; Ruiz, Daniel Small, Vol. 8, Issue 13 https://doi.org/10.1002/smll.201101593	journal	April 2012
Insight Into the Kinetic of Amyloid β (1–42) Peptide Self-Aggregation: Elucidation of Inhibitors’ Mechanism of Action Bartolini, Manuela; Bertucci, Carlo; Bolognesi, Maria Laura ChemBioChem, Vol. 8, Issue 17 https://doi.org/10.1002/cbic.200700427	journal	November 2007
Viscoelasticity In Aqueous Soap Solutions Pilpel, N. The Journal of Physical Chemistry, Vol. 60, Issue 6 https://doi.org/10.1021/j150540a018	journal	June 1956
Central amyloid- -specific single chain variable fragment ameliorates A aggregation and neurotoxicity Nisbet, R. M.; Nigro, J.; Breheney, K. Protein Engineering Design and Selection, Vol. 26, Issue 10 https://doi.org/10.1093/protein/gzt025	journal	June 2013
Monitoring the Transition from Spherical to Polymer-like Surfactant Micelles Using Small-Angle X-Ray Scattering Jensen, Grethe Vestergaard; Lund, Reidar; Gummel, Jérémie Angewandte Chemie International Edition, Vol. 53, Issue 43 https://doi.org/10.1002/anie.201406489	journal	September 2014
Tau-targeting therapies for Alzheimer disease Congdon, Erin E.; Sigurdsson, Einar M. Nature Reviews Neurology, Vol. 14, Issue 7 https://doi.org/10.1038/s41582-018-0013-z	journal	June 2018
Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery Oller-Salvia, Benjamí; Sánchez-Navarro, Macarena; Giralt, Ernest Chemical Society Reviews, Vol. 45, Issue 17 https://doi.org/10.1039/C6CS00076B	journal	January 2016
A new era for understanding amyloid structures and disease Iadanza, Matthew G.; Jackson, Matthew P.; Hewitt, Eric W. Nature Reviews Molecular Cell Biology, Vol. 19, Issue 12 https://doi.org/10.1038/s41580-018-0060-8	journal	September 2018
Intraneuronal beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation Oakley, H.; Cole, S. L.; Logan, S. Journal of Neuroscience, Vol. 26, Issue 40 https://doi.org/10.1523/JNEUROSCI.1202-06.2006	journal	October 2006
Alzheimer disease in the United States (2010-2050) estimated using the 2010 census Hebert, L. E.; Weuve, J.; Scherr, P. A. Neurology, Vol. 80, Issue 19 https://doi.org/10.1212/WNL.0b013e31828726f5	journal	February 2013
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity Bieschke, Jan; Russ, Jenny; Friedrich, Ralf P. Proceedings of the National Academy of Sciences, Vol. 107, Issue 17 https://doi.org/10.1073/pnas.0910723107	journal	April 2010
MicroScale Thermophoresis: Interaction analysis and beyond Jerabek-Willemsen, Moran; André, Timon; Wanner, Randy Journal of Molecular Structure, Vol. 1077 https://doi.org/10.1016/j.molstruc.2014.03.009	journal	December 2014
Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer’s Disease Li, Meng; Howson, Suzanne E.; Dong, Kai Journal of the American Chemical Society, Vol. 136, Issue 33 https://doi.org/10.1021/ja502789e	journal	August 2014
Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide Guan, Yijia; Du, Zhi; Gao, Nan Science Advances, Vol. 4, Issue 1 https://doi.org/10.1126/sciadv.aao6718	journal	January 2018
Quantitative assessment of organic compounds adsorbed on silica gel by FTIR and UV–VIS spectroscopies: the contribution of diffuse reflectance spectroscopy Péré, E.; Cardy, H.; Cairon, O. Vibrational Spectroscopy, Vol. 25, Issue 2 https://doi.org/10.1016/S0924-2031(00)00113-2	journal	May 2001
Crossing the blood-brain barrier with nanoparticles Zhou, Yiqun; Peng, Zhili; Seven, Elif S. Journal of Controlled Release, Vol. 270 https://doi.org/10.1016/j.jconrel.2017.12.015	journal	January 2018
Testing the Right Target and Right Drug at the Right Stage Sperling, R. A.; Jack, C. R.; Aisen, P. S. Science Translational Medicine, Vol. 3, Issue 111 https://doi.org/10.1126/scitranslmed.3002609	journal	November 2011
The secretases: enzymes with therapeutic potential in Alzheimer disease De Strooper, Bart; Vassar, Robert; Golde, Todd Nature Reviews Neurology, Vol. 6, Issue 2 https://doi.org/10.1038/nrneurol.2009.218	journal	February 2010
Subcellular localization of the Alzheimer's disease amyloid precursor protein and derived polypeptides expressed in a recombinant yeast system Culvenor, Janetta G.; Henry, Anna; Hartmann, Tobias Amyloid, Vol. 5, Issue 2 https://doi.org/10.3109/13506129808995285	journal	January 1998
Metallosupramolecular complex targeting an α/β discordant stretch of amyloid β peptide Yu, Haijia; Li, Meng; Liu, Gongping Chemical Science, Vol. 3, Issue 11 https://doi.org/10.1039/c2sc20372c	journal	January 2012
Nanocomposites Inhibit the Formation, Mitigate the Neurotoxicity, and Facilitate the Removal of β-Amyloid Aggregates in Alzheimer’s Disease Mice Zhao, Yu; Cai, Jinquan; Liu, Zichen Nano Letters, Vol. 19, Issue 2 https://doi.org/10.1021/acs.nanolett.8b03644	journal	November 2018
Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances Narayan, Reema; Nayak, Usha; Raichur, Ashok Pharmaceutics, Vol. 10, Issue 3 https://doi.org/10.3390/pharmaceutics10030118	journal	August 2018
Generation of a recombinant Fab antibody reactive with the Alzheimer's disease-related Aβ peptide Tammer, A. H.; Coia, G.; Cappai, R. Clinical & Experimental Immunology, Vol. 129, Issue 3 https://doi.org/10.1046/j.1365-2249.2002.01905.x	journal	September 2002
Characterization of micellar aggregates in viscoelastic surfactant solutions. A nuclear magnetic resonance and light scattering study Olsson, Ulf; Soederman, Olle; Guering, Paul The Journal of Physical Chemistry, Vol. 90, Issue 21 https://doi.org/10.1021/j100412a066	journal	October 1986
Peptide Design Principles for Antimicrobial Applications Torres, Marcelo D. T.; Sothiselvam, Shanmugapriya; Lu, Timothy K. Journal of Molecular Biology, Vol. 431, Issue 18 https://doi.org/10.1016/j.jmb.2018.12.015	journal	August 2019

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