Analysis of muntjac deer genome and chromatin architecture reveals rapid karyotype evolution

Mudd, Austin B.; Bredeson, Jessen V.; Baum, Rachel; Hockemeyer, Dirk; Rokhsar, Daniel S.

doi:10.1038/s42003-020-1096-9

Analysis of muntjac deer genome and chromatin architecture reveals rapid karyotype evolution

Journal Article · Tue Sep 01 00:00:00 EDT 2020 · Communications Biology

DOI:https://doi.org/10.1038/s42003-020-1096-9· OSTI ID:1657263

; ; Baum, Rachel; ;

Abstract

Closely related muntjac deer show striking karyotype differences. Here we describe chromosome-scale genome assemblies for Chinese and Indian muntjacs, Muntiacus reevesi (2 n = 46) and Muntiacus muntjak vaginalis (2 n = 6/7), and analyze their evolution and architecture. The genomes show extensive collinearity with each other and with other deer and cattle. We identified numerous fusion events unique to and shared by muntjacs relative to the cervid ancestor, confirming many cytogenetic observations with genome sequence. One of these M. muntjak fusions reversed an earlier fission in the cervid lineage. Comparative Hi-C analysis showed that the chromosome fusions on the M. muntjak lineage altered long-range, three-dimensional chromosome organization relative to M. reevesi in interphase nuclei including A/B compartment structure. This reshaping of multi-megabase contacts occurred without notable change in local chromatin compaction, even near fusion sites. A few genes involved in chromosome maintenance show evidence for rapid evolution, possibly associated with the dramatic changes in karyotype.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1657263

Alternate ID(s):: OSTI ID: 1817128

Journal Information:: Communications Biology, Journal Name: Communications Biology Journal Issue: 1 Vol. 3; ISSN 2399-3642

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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