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Title: Methods for treating diseases related to the wnt pathway

Patent ·
OSTI ID:1650782

The present invention relates to methods for treating a disease, in which the disease arises from dysregulation of the Wnt signaling pathway. In some instances, the disease can be treated by administering a Wnt pathway inhibitory compound. In other instances, the method optionally includes conducting a genome-wide screening to determine one or more genes resulting in a reduced disease state and then identifying the gene(s) as being involved in the Wnt signaling pathway.

Research Organization:
Sandia National Lab. (SNL-CA), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC04-94AL85000
Assignee:
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
Patent Number(s):
10,624,949
Application Number:
15/204,804
OSTI ID:
1650782
Resource Relation:
Patent File Date: 07/07/2016
Country of Publication:
United States
Language:
English

References (15)

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Porous Nanoparticle-Supported Lipid Bilayers (Protocells) for Targeted Delivery Including Transdermal Delivery of Cargo and Methods thereof patent-application October 2015
Compositions and Methods for Potentiation of Cancer Agents patent-application August 2012
Microelectroporation device for genomic screening patent September 2014
WNT Protein Signaling Inhibitors patent-application February 2014
WNT Protein Signaling Inhibitors patent-application December 2015
Interaction Inhibitors of TCF-4 with Beta-Catenin patent-application October 2004
Wnt Protein Signalling Inhibitors patent-application June 2015
WNT Pathway Inhibitors for Treating Viral Infections patent-application September 2014
Substituted 1H-Indazol-1-Ol Analogs as Inhibitors of Beta Catenin/TcF Protein-Protein Interactions patent-application January 2015
Antiviral Axin Stabilizer patent-application March 2017
Triazole Derivatives as Wnt Signaling Pathway Inhibitors patent-application November 2015
N-(Hetero)Aryl, 2-(Hetero)Aryl-Substituted Acetamides for Use as Wnt Signaling Modulators patent-application March 2016

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