Cognition may link cortical IGFBP5 levels with motor function in older adults

Buchman, Aron S.; Yu, Lei; Petyuk, Vladislav A.; Gaiteri, Chris; Tasaki, Shinya; Blizinsky, Katherine D.; Schneider, Julie A.; De Jager, Philip L.; Bennett, David A.

doi:10.1371/journal.pone.0220968

Cognition may link cortical IGFBP5 levels with motor function in older adults

Journal Article · Mon Aug 12 00:00:00 EDT 2019 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0220968· OSTI ID:1642067

^[1]; Yu, Lei ^[1]; Petyuk, Vladislav A. ^[2]; Gaiteri, Chris ^[1]; Tasaki, Shinya ^[1]; Blizinsky, Katherine D. ^[3]; Schneider, Julie A. ^[1]; De Jager, Philip L. ^[4]; Bennett, David A. ^[1]

Rush Univ. Medical Center, Chicago, IL (United States). Rush Alzheimer's Disease Center; Rush Univ. Medical Center, Chicago, IL (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Rush Univ. Medical Center, Chicago, IL (United States). Rush Alzheimer's Disease Center; National Inst. of Health (NIH), Bethesda, MD (United States). National Human Genome Research Inst.
Columbia Univ. Medical Center, New York, NY (United States); Broad Inst., Cambridge, MA (United States). Cell Circuits Program

Alzheimer’s disease and related disorders (ADRD) may manifest cognitive and non-cognitive phenotypes including motor impairment, suggesting a shared underlying biology. We tested the hypothesis that five cortical proteins identified from a gene network that drives AD and cognitive phenotypes are also related to motor function in the same individuals. We examined 1208 brains of older adults with motor and cognitive assessments prior to death. Cortical proteins were quantified with SRM proteomics and we collected indices of AD and other related pathologies. A higher level of IGFBP5 was associated with poorer motor function proximate to death but AK4, HSPB2, ITPK1 and PLXNB1 were unrelated to motor function. The association of IGFBP5 with motor function was unrelated to the presence of indices of brain pathologies. In contrast, the addition of a term for cognition attenuated the association of IGFBP5 with motor function by about 90% and they were no longer related. These data lend support for the idea that unidentified cortical proteins like IGFBP5, which may not manifest a known pathologic footprint, may contribute to motor and cognitive function in older adults.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1642067

Report Number(s):: PNNL-SA--147561

Journal Information:: PLoS ONE, Journal Name: PLoS ONE Journal Issue: 8 Vol. 14; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

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Cognition may link cortical IGFBP5 levels with motor function in older adults

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