Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection
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journal
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December 2018 |
Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study
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journal
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May 2016 |
Comparison of Zinc Finger Nucleases Versus CRISPR-Specific Nucleases for Genome Editing of the Wiskott-Aldrich Syndrome Locus
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journal
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March 2018 |
Chromosomal rearrangements in cancer: Detection and potential causal mechanisms
|
journal
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January 2014 |
Expanding the Biologist’s Toolkit with CRISPR-Cas9
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journal
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May 2015 |
Continuous evolution of base editors with expanded target compatibility and improved activity
|
journal
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July 2019 |
Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient
|
journal
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May 2013 |
Targeted Correction and Restored Function of the CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells
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journal
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April 2015 |
Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice
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journal
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July 2019 |
A highly specific SpCas9 variant is identified by in vivo screening in yeast
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journal
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January 2018 |
In vivo genome editing restores haemostasis in a mouse model of haemophilia
|
journal
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June 2011 |
Increasing the specificity of CRISPR systems with engineered RNA secondary structures
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journal
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April 2019 |
UDiTaS™, a genome editing detection method for indels and genome rearrangements
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journal
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March 2018 |
Database resources of the National Center for Biotechnology Information
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journal
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November 2018 |
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
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journal
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April 2017 |
CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency
|
journal
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December 2018 |
Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference
|
journal
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October 2018 |
HPV Oncogene Manipulation Using Nonvirally Delivered CRISPR/Cas9 or Natronobacterium gregoryi Argonaute
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journal
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May 2018 |
DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells
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journal
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July 2018 |
An enhanced CRISPR repressor for targeted mammalian gene regulation
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journal
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July 2018 |
Optimized base editors enable efficient editing in cells, organoids and mice
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journal
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October 2018 |
Review of CRISPR/Cas9 sgRNA Design Tools
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journal
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April 2018 |
Simultaneous Knockout of CXCR4 and CCR5 Genes in CD4+ T Cells via CRISPR/Cas9 Confers Resistance to Both X4- and R5-Tropic Human Immunodeficiency Virus Type 1 Infection
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journal
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January 2018 |
CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
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journal
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March 2007 |
Highly efficient base editing in bacteria using a Cas9-cytidine deaminase fusion
|
journal
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April 2018 |
Prevalence of Pre-existing Antibodies to CRISPR-Associated Nuclease Cas9 in the USA Population
|
journal
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September 2018 |
KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions
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journal
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June 2013 |
Dose-Dependent Prevention of Metabolic and Neurologic Disease in Murine MPS II by ZFN-Mediated In Vivo Genome Editing
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journal
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April 2018 |
The implication of CRISPR/Cas9 genome editing technology in combating human oncoviruses
|
journal
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September 2018 |
Editing the epigenome: technologies for programmable transcription and epigenetic modulation
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journal
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January 2016 |
Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions
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journal
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August 2016 |
Rationally engineered Cas9 nucleases with improved specificity
|
journal
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December 2015 |
Correction of IVS I-110(G>A) β-thalassemia by CRISPR/Cas-and TALEN-mediated disruption of aberrant regulatory elements in human hematopoietic stem and progenitor cells
|
journal
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April 2019 |
Engineering the Delivery System for CRISPR-Based Genome Editing
|
journal
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February 2018 |
Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
|
journal
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December 2015 |
Somatic Gene Editing of GUCY2D by AAV-CRISPR/Cas9 Alters Retinal Structure and Function in Mouse and Macaque
|
journal
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May 2019 |
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
|
journal
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August 2013 |
Therapeutic Genome Editing With CRISPR/Cas9 in a Humanized Mouse Model Ameliorates α1-antitrypsin Deficiency Phenotype
|
journal
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March 2018 |
PD-1 blockade modulates chimeric antigen receptor (CAR)–modified T cells: refueling the CAR
|
journal
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February 2017 |
Chimeric Antigen Receptor– and TCR-Modified T Cells Enter Main Street and Wall Street
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journal
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July 2015 |
A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging
|
journal
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October 2014 |
CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells
|
journal
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October 2015 |
Genome-wide profiling of adenine base editor specificity by EndoV-seq
|
journal
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January 2019 |
USH2A Gene Editing Using the CRISPR System
|
journal
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September 2017 |
Targeted genome editing in human repopulating haematopoietic stem cells
|
journal
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May 2014 |
Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
|
journal
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December 2013 |
Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV
|
journal
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March 2014 |
Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation
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journal
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February 2009 |
Targeted DNA methylation in human cells using engineered dCas9-methyltransferases
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journal
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July 2017 |
T-cell receptor gene therapy - ready to go viral?
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journal
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October 2015 |
Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase
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journal
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November 2016 |
DNA-binding-domain fusions enhance the targeting range and precision of Cas9
|
journal
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October 2015 |
The diverse functions of histone lysine methylation
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journal
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November 2005 |
Kruppel-associated boxes are potent transcriptional repression domains.
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journal
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May 1994 |
A Universal Approach to Correct Various HBB Gene Mutations in Human Stem Cells for Gene Therapy of Beta-Thalassemia and Sickle Cell Disease: Universal Correction of Various HBB Gene Mutations
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journal
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November 2017 |
Oncogenic Human Papillomavirus: Application of CRISPR/Cas9 Therapeutic Strategies for Cervical Cancer
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journal
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January 2017 |
Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction
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journal
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December 2018 |
Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases
|
journal
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January 2016 |
Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1
|
journal
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October 2017 |
Delivering CRISPR: a review of the challenges and approaches
|
journal
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January 2018 |
Optical control of mammalian endogenous transcription and epigenetic states
|
journal
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August 2013 |
Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
|
journal
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August 2016 |
RNA editing with CRISPR-Cas13
|
journal
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October 2017 |
Clinical use of lentiviral vectors
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journal
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March 2018 |
CRISPR Correction of Duchenne Muscular Dystrophy
|
journal
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January 2019 |
Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition
|
journal
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November 2016 |
Quantifying CRISPR off-target effects
|
journal
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May 2019 |
End of Phase 1 Results from Zuma-6: Axicabtagene Ciloleucel (Axi-Cel) in Combination with Atezolizumab for the Treatment of Patients with Refractory Diffuse Large B Cell Lymphoma
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journal
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March 2019 |
Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
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journal
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July 2017 |
Tumor-infiltrating lymphocytes for the treatment of metastatic cancer
|
journal
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October 2015 |
A multifunctional AAV–CRISPR–Cas9 and its host response
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journal
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September 2016 |
Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration
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journal
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June 2019 |
Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
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journal
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May 2017 |
Pharmaceutical Development of AAV-Based Gene Therapy Products for the Eye
|
journal
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December 2018 |
Comparison of Cas9 activators in multiple species
|
journal
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May 2016 |
Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
|
journal
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April 2014 |
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
|
journal
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April 2014 |
Targeting cellular mRNAs translation by CRISPR-Cas9
|
journal
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July 2016 |
CRISPR in personalized medicine: Industry perspectives in gene editing
|
journal
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December 2018 |
Targeted in vivo knock-in of human alpha-1-antitrypsin cDNA using adenoviral delivery of CRISPR/Cas9
|
journal
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March 2018 |
CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs
|
journal
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April 2016 |
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
|
journal
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February 2013 |
High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing
|
journal
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March 2018 |
Programmable RNA recognition and cleavage by CRISPR/Cas9
|
journal
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September 2014 |
Editing DNA Methylation in the Mammalian Genome
|
journal
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September 2016 |
Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations
|
journal
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January 2018 |
Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia
|
journal
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September 2016 |
Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation
|
journal
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December 2015 |
Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA
|
journal
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August 2014 |
DNA methylation and the regulation of gene transcription
|
journal
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February 2002 |
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
|
journal
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July 2013 |
The CRISPR tool kit for genome editing and beyond
|
journal
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May 2018 |
CRISPR’d babies: human germline genome editing in the ‘He Jiankui affair’*
|
journal
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August 2019 |
Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors
|
journal
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April 2018 |
Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1
|
journal
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December 2004 |
ZFN-Mediated In Vivo Genome Editing Corrects Murine Hurler Syndrome
|
journal
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January 2019 |
10 Years of GWAS Discovery: Biology, Function, and Translation
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journal
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July 2017 |
CRISPR RNAs trigger innate immune responses in human cells
|
journal
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February 2018 |
In vivo base editing of post-mitotic sensory cells
|
journal
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June 2018 |
Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs
|
journal
|
September 2015 |
The potential and challenges of CRISPR-Cas in eradication of hepatitis B virus covalently closed circular DNA
|
journal
|
January 2018 |
Initial sequencing and analysis of the human genome
|
journal
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February 2001 |
Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system
|
journal
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July 2017 |
Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option
|
journal
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October 2018 |
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
|
journal
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October 2014 |
RNA-guided DNA insertion with CRISPR-associated transposases
|
journal
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June 2019 |
Biological plasticity rescues target activity in CRISPR knock outs
|
journal
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October 2019 |
The CRISPR-baby scandal: what’s next for human gene-editing
|
journal
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February 2019 |
Sequence determinants of improved CRISPR sgRNA design
|
journal
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June 2015 |
RNA-guided gene activation by CRISPR-Cas9–based transcription factors
|
journal
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July 2013 |
Cas9/gRNA targeted excision of cystic fibrosis-causing deep-intronic splicing mutations restores normal splicing of CFTR mRNA
|
journal
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September 2017 |
Impact of the KU80 Pathway on NHEJ-Induced Genome Rearrangements in Mammalian Cells
|
journal
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June 2004 |
Human Germline Genome Editing
|
journal
|
August 2017 |
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
|
journal
|
January 2014 |
A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing
|
journal
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February 2018 |
CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein
|
journal
|
March 2017 |
Safe engineering of CAR T cells for adoptive cell therapy of cancer using long‐term episomal gene transfer
|
journal
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May 2016 |
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
|
journal
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September 2008 |
Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9
|
journal
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October 2013 |
The urgent need to recover MHC class I in cancers for effective immunotherapy
|
journal
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April 2016 |
Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing
|
journal
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July 2018 |
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
|
journal
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June 2008 |
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
|
journal
|
June 2012 |
A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells
|
journal
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August 2018 |
CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease
|
journal
|
January 2017 |
Multidimensional Genome-wide Analyses Show Accurate FVIII Integration by ZFN in Primary Human Cells
|
journal
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March 2016 |
Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases
|
journal
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February 2018 |
Correction of a pathogenic gene mutation in human embryos
|
journal
|
August 2017 |
TALENs: a widely applicable technology for targeted genome editing
|
journal
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November 2012 |
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
|
journal
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February 2018 |
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation
|
journal
|
February 2012 |
Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies
|
journal
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July 2015 |
DNA stretching induces Cas9 off-target activity
|
journal
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February 2019 |
Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies
|
journal
|
December 2018 |
Intrinsic Nucleotide Preference of Diversifying Base Editors Guides Antibody Ex Vivo Affinity Maturation
|
journal
|
October 2018 |
Multiplex Genome Engineering Using CRISPR/Cas Systems
|
journal
|
January 2013 |
Locus-specific editing of histone modifications at endogenous enhancers
|
journal
|
December 2013 |
The Conformational Dynamics of Cas9 Governing DNA Cleavage Are Revealed by Single-Molecule FRET
|
journal
|
January 2018 |
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
|
journal
|
October 2017 |
In vivo genome editing of the albumin locus as a platform for protein replacement therapy
|
journal
|
October 2015 |
Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells
|
journal
|
December 2013 |
Targeted Methylation and Gene Silencing of VEGF-A in Human Cells by Using a Designed Dnmt3a–Dnmt3L Single-Chain Fusion Protein with Increased DNA Methylation Activity
|
journal
|
February 2013 |
Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma
|
journal
|
August 2015 |
An effective and biocompatible polyethylenimine based vaginal suppository for gene delivery
|
journal
|
August 2019 |
Efficient Gene Editing at Major CFTR Mutation Loci
|
journal
|
June 2019 |
CRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo
|
journal
|
October 2018 |
TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts
|
journal
|
April 2015 |
Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34 + Hematopoietic Stem and Progenitor Cells
|
journal
|
March 2017 |
Engineering of high-precision base editors for site-specific single nucleotide replacement
|
journal
|
January 2019 |
CRISPR, Prime Editing, Optogenetics, and DREADDs: New Therapeutic Approaches Provided by Emerging Technologies in the Treatment of Spinal Cord Injury
|
journal
|
January 2020 |
Multidimensional chemical control of CRISPR–Cas9
|
journal
|
October 2016 |
Highly efficient and precise base editing by engineered dCas9-guide tRNA adenosine deaminase in rats
|
journal
|
July 2018 |
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
|
journal
|
December 2014 |
Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors
|
journal
|
November 2009 |
Crystal Structure of Staphylococcus aureus Cas9
|
journal
|
August 2015 |
CRISPR RNA–guided activation of endogenous human genes
|
journal
|
July 2013 |
Correction of the ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Gene by Zinc-Finger Nuclease Homology-Directed Repair
|
journal
|
June 2012 |
Immunogenicity of somatic mutations in human gastrointestinal cancers
|
journal
|
October 2015 |
DNA methylation: roles in mammalian development
|
journal
|
February 2013 |
Functional annotation of native enhancers with a Cas9–histone demethylase fusion
|
journal
|
March 2015 |
Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips
|
journal
|
June 2017 |
Gene delivery to the lungs: pulmonary gene therapy for cystic fibrosis
|
journal
|
March 2017 |
Target specificity of the CRISPR-Cas9 system
|
journal
|
June 2014 |
Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infection
|
journal
|
September 2017 |
CRISPR-Based Technologies: Impact of RNA-Targeting Systems
|
journal
|
November 2018 |
DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A
|
journal
|
September 2017 |
Reprogramming human T cell function and specificity with non-viral genome targeting
|
journal
|
July 2018 |
Abstract CT133: A phase I trial of PD-1 deficient engineered T cells with CRISPR/Cas9 in patients with advanced non-small cell lung cancer with PD-L1 expression
|
conference
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July 2018 |
CRISPR/Cas9-mediated PD-1 disruption enhances human mesothelin-targeted CAR T cell effector functions
|
journal
|
December 2018 |
Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
|
journal
|
December 2017 |
A CRISPR-based approach for targeted DNA demethylation
|
journal
|
May 2016 |
CRISPR interference-based specific and efficient gene inactivation in the brain
|
journal
|
February 2018 |
Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein
|
journal
|
July 2017 |
The impact of chromosomal rearrangements on regulation of gene expression
|
journal
|
June 2014 |
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
|
journal
|
April 2019 |
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
|
journal
|
September 2013 |
Nucleic Acid Recognition by the Innate Immune System
|
journal
|
April 2011 |
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
|
journal
|
June 2016 |
Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation
|
journal
|
May 2016 |
Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion
|
journal
|
February 2017 |
The New State of the Art: Cas9 for Gene Activation and Repression
|
journal
|
September 2015 |
Highly efficient RNA-guided base editing in mouse embryos
|
journal
|
February 2017 |
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
|
journal
|
December 2013 |
Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy
|
journal
|
August 2018 |
The CRIPSR /Cas gene‐editing system—an immature but useful toolkit for experimental and clinical medicine
|
journal
|
March 2019 |
High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population
|
journal
|
October 2018 |
Tumour suppression by targeted intravenous non-viral CRISPRa using dendritic polymers
|
journal
|
January 2019 |
Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria
|
journal
|
April 2000 |
Amelioration of Alpha-1 Antitrypsin Deficiency Diseases with Genome Editing in Transgenic Mice
|
journal
|
August 2018 |
Engineered T cells: the promise and challenges of cancer immunotherapy
|
journal
|
August 2016 |
Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia
|
journal
|
September 2010 |
In Vivo Genome Editing Partially Restores Alpha1-Antitrypsin in a Murine Model of AAT Deficiency
|
journal
|
August 2018 |
Genome Engineering With Zinc-Finger Nucleases
|
journal
|
August 2011 |
Development of Novel Efficient SIN Vectors with Improved Safety Features for Wiskott–Aldrich Syndrome Stem Cell Based Gene Therapy
|
journal
|
July 2011 |
Identification of preexisting adaptive immunity to Cas9 proteins in humans
|
journal
|
January 2019 |
Advances with using CRISPR/Cas-mediated gene editing to treat infections with hepatitis B virus and hepatitis C virus
|
journal
|
January 2018 |
Author Correction: Gene correction for SCID-X1 in long-term hematopoietic stem cells
|
journal
|
December 2019 |
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
|
journal
|
November 2017 |
Translation of CRISPR Genome Surgery to the Bedside for Retinal Diseases
|
journal
|
May 2018 |
Zinc Finger Nucleases Targeting the Human Papillomavirus E7 Oncogene Induce E7 Disruption and a Transformed Phenotype in HPV16/18-Positive Cervical Cancer Cells
|
journal
|
October 2014 |
In Vivo Applications of CRISPR-Based Genome Editing in the Retina
|
journal
|
May 2018 |
The RNA binding site of bacteriophage MS2 coat protein.
|
journal
|
February 1993 |
Increasing Cas9-mediated homology-directed repair efficiency through covalent tethering of DNA repair template
|
journal
|
May 2018 |
An AAVS1-Targeted Minigene Platform for Correction of iPSCs From All Five Types of Chronic Granulomatous Disease
|
journal
|
January 2015 |
Genome-wide tracking of dCas9-methyltransferase footprints
|
journal
|
February 2018 |
A phase I trial of PD-1 deficient engineered T cells with CRISPR/Cas9 in patients with advanced non-small cell lung cancer.
|
journal
|
May 2018 |
The Pharmacology of T Cell Therapies
|
journal
|
March 2018 |
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing
|
journal
|
September 2016 |
Regulation of chromatin by histone modifications
|
journal
|
February 2011 |
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
|
journal
|
April 2006 |
Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair
|
journal
|
February 2016 |
RNA-Guided Human Genome Engineering via Cas9
|
journal
|
January 2013 |
CRISPR gene-editing tested in a person for the first time
|
journal
|
November 2016 |
dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression
|
journal
|
July 2017 |
Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac
|
journal
|
August 2014 |
Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects
|
journal
|
March 2011 |
Novel AIDS therapies based on gene editing
|
journal
|
February 2017 |
Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection
|
journal
|
June 2014 |
Posttransplant chimeric antigen receptor therapy
|
journal
|
March 2018 |
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity
|
journal
|
August 2017 |
One-step genetic correction of hemoglobin E/beta-thalassemia patient-derived iPSCs by the CRISPR/Cas9 system
|
journal
|
February 2018 |
Programmable RNA Cleavage and Recognition by a Natural CRISPR-Cas9 System from Neisseria meningitidis
|
journal
|
March 2018 |
Immunity to CRISPR Cas9 and Cas12a therapeutics: Immunity to CRISPR Cas9 and Cas12a therapeutics
|
journal
|
October 2017 |
RNA targeting with CRISPR–Cas13
|
journal
|
October 2017 |
NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives
|
journal
|
May 2018 |
Targeted Integration of a Super-Exon into the CFTR Locus Leads to Functional Correction of a Cystic Fibrosis Cell Line Model
|
journal
|
August 2016 |
Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
|
journal
|
June 2015 |
CRISPR–Cas9 Structures and Mechanisms
|
journal
|
May 2017 |
CAR T cell immunotherapy for human cancer
|
journal
|
March 2018 |
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
|
journal
|
July 2013 |
Repurposing the CRISPR-Cas9 system for targeted DNA methylation
|
journal
|
March 2016 |
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation
|
journal
|
December 2017 |
Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
|
journal
|
December 2014 |
Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9
|
journal
|
August 2017 |
CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
|
journal
|
June 2018 |
Cas9-mediated targeting of viral RNA in eukaryotic cells
|
journal
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April 2015 |
CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9
|
journal
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March 2018 |
Clinical trials of dual-target CAR T cells, donor-derived CAR T cells, and universal CAR T cells for acute lymphoid leukemia
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journal
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February 2019 |
Sangamo's landmark genome editing trial gets mixed reception
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journal
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October 2018 |
Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells
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journal
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January 2017 |
Genome editing reveals a role for OCT4 in human embryogenesis
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journal
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September 2017 |
Genetic Modification of the Lung Directed Toward Treatment of Human Disease
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journal
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January 2017 |
TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy
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journal
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December 2014 |
A CRISPR/Cas system mediates bacterial innate immune evasion and virulence
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journal
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April 2013 |
TALEN-mediated functional correction of X-linked chronic granulomatous disease in patient-derived induced pluripotent stem cells
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journal
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November 2015 |
RNA-dependent RNA targeting by CRISPR-Cas9
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journal
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January 2018 |
Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
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journal
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January 2014 |
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
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journal
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January 2016 |
Treating Immunodeficiency through HSC Gene Therapy
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journal
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April 2016 |
Targeting fidelity of adenine and cytosine base editors in mouse embryos
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journal
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November 2018 |
In vivo CRISPR editing with no detectable genome-wide off-target mutations
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journal
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September 2018 |
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
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journal
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September 2017 |
In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway
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journal
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July 2018 |
Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy
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journal
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February 2019 |
Off-target Effects in CRISPR/Cas9-mediated Genome Engineering
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journal
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January 2015 |
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
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journal
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February 2014 |
Improving CRISPR–Cas specificity with chemical modifications in single-guide RNAs
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journal
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December 2017 |
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
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journal
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April 2015 |
Genome-wide target specificity of CRISPR RNA-guided adenine base editors
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journal
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March 2019 |
Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
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journal
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January 2019 |
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
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journal
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April 2016 |
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
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journal
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April 2016 |
LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1
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journal
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October 2003 |
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
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journal
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February 2017 |
Human germline genome editing
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journal
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December 2019 |
Targeting HPV16 DNA using CRISPR/Cas inhibits anal cancer growth in vivo
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journal
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July 2018 |
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
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journal
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October 2014 |
Robust ZFN-mediated genome editing in adult hemophilic mice
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journal
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November 2013 |
RNA-guided genetic silencing systems in bacteria and archaea
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journal
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February 2012 |
Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance
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journal
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November 2015 |
RNA-targeting CRISPR comes of age
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journal
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January 2018 |
CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies
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journal
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July 2017 |
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
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journal
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April 2015 |
The Combination of CRISPR/Cas9 and iPSC Technologies in the Gene Therapy of Human β-thalassemia in Mice
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journal
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September 2016 |
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
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journal
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August 2013 |
Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems
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journal
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March 2017 |
Targeted gene addition in human CD34+ hematopoietic cells for correction of X-linked chronic granulomatous disease
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journal
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March 2016 |
Highly efficient Cas9-mediated transcriptional programming
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journal
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March 2015 |
Germline genome editing versus preimplantation genetic diagnosis: Is there a case in favour of germline interventions?
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journal
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August 2019 |
Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases
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journal
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March 2016 |
Seeing the Light after 25 Years of Retinal Gene Therapy
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journal
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August 2018 |
CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter
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journal
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June 2016 |
Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection
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journal
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January 2014 |
A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens
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journal
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March 2019 |
p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
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journal
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June 2018 |
A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs
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journal
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June 2018 |
Preliminary Results of Prophylactic Tocilizumab after Axicabtageneciloleucel (axi-cel; KTE-C19) Treatment for Patients with Refractory,Aggressive Non-Hodgkin Lymphoma (NHL)
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journal
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December 2017 |
Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq
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journal
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April 2019 |
Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
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journal
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April 2019 |
Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice
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journal
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February 2019 |