skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors

Journal Article · · Journal of Medicinal Chemistry
 [1]; ORCiD logo [2];  [3];  [4];  [2];  [4];  [5];  [5];  [5];  [6];  [7];  [3];  [3];  [2];  [3];  [3];  [3];  [8];  [1]; ORCiD logo [1]
  1. Department of Early Discovery Chemistry, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492, United States
  2. Department of Chemistry, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492, United States
  3. Department of Virology Discovery Biology, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492, United States
  4. Department of Computer-Aided Drug Design & Molecular Analytics, Bristol-Myers Squibb Research and Development, Princeton, New Jersey 08543-4000, United States
  5. Department of Molecular Structure and Design, Bristol-Myers Squibb Research and Development, Princeton, New Jersey 08543-4000, United States
  6. Department of Materials Science, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492, United States
  7. Department of Chemistry, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States
  8. Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492, United States
+ Show Author Affiliations

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
INDUSTRY
OSTI ID:
1635033
Journal Information:
Journal of Medicinal Chemistry, Vol. 63, Issue 5; ISSN 0022-2623
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
ENGLISH

Similar Records

Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3 H -imidazo[4,5- b ]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor
Journal Article · Wed Jun 15 00:00:00 EDT 2016 · Journal of Medicinal Chemistry · OSTI ID:1635033
+17 more
Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses
Journal Article · Fri Jul 10 00:00:00 EDT 2009 · J. Med. Chem. · OSTI ID:1635033
+18 more
The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer
Journal Article · Wed Sep 18 00:00:00 EDT 2013 · J. Med. Chem. · OSTI ID:1635033
+17 more

Related Subjects