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Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors

Journal Article · · Journal of Medicinal Chemistry
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  1. Department of Early Discovery Chemistry, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492, United States
  2. Department of Chemistry, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492, United States
  3. Department of Virology Discovery Biology, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492, United States
  4. Department of Computer-Aided Drug Design & Molecular Analytics, Bristol-Myers Squibb Research and Development, Princeton, New Jersey 08543-4000, United States
  5. Department of Molecular Structure and Design, Bristol-Myers Squibb Research and Development, Princeton, New Jersey 08543-4000, United States
  6. Department of Materials Science, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492, United States
  7. Department of Chemistry, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States
  8. Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492, United States
+ Show Author Affiliations
Abstract not provided
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
INDUSTRY
OSTI ID:
1635033
Journal Information:
Journal of Medicinal Chemistry, Journal Name: Journal of Medicinal Chemistry Journal Issue: 5 Vol. 63; ISSN 0022-2623
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
ENGLISH

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