Validation of Stage N3 of the Eighth Edition AJCC Staging System for Nasopharyngeal Carcinoma

Pan, Xin‐Bin; Qu, Song; Li, Ling; Chen, Long; Liang, Shi‐Xiong; Zhu, Xiao‐Dong

doi:10.1002/lary.28825

Validation of Stage N3 of the Eighth Edition AJCC Staging System for Nasopharyngeal Carcinoma

Journal Article · Thu Jun 18 00:00:00 EDT 2020 · Laryngoscope

DOI:https://doi.org/10.1002/lary.28825· OSTI ID:1633844

Pan, Xin‐Bin ^[1]; Qu, Song; Li, Ling; Chen, Long; Liang, Shi‐Xiong;

Department of Radiation Oncology Guangxi Medical University Cancer Hospital Nanning People's Republic of China

Objectives

To validate stage nodal (N)3 of the 8th edition American Joint Committee on Cancer (AJCC) staging system for nasopharyngeal carcinoma (NPC).

Methods

This retrospective cohort study extracted NPC patients from the Surveillance, Epidemiology, and End Results database between 2004 and 2016. Pathologically confirmed patients with complete data of level IV, N3a, and N3b lymph node metastasis were investigated. The included patients were divided into level IV, N3a, and N3b groups. Five‐year overall survival (OS) and cancer‐specific survival (CSS) were compared among the three groups.

Results

A total of 693 patients were included: 285 (41.13%) patients in the level IV group, 124 (17.89%) patients in the N3a group, and 284 (40.98%) patients in the N3b group. The 5‐year OS (57.1%, 55.0%, and 55.2%) and CSS (64.4%, 63.5%, and 64.4%) were not different among the level IV, N3a, and N3b groups. Multivariate regression analysis revealed that N stage was not an independent prognostic factor for OS (hazard ratio [HR] = 1.03, 95% confidence interval [CI]: 0.91–1.17; P = .65) or CSS (HR = 1.03, 95% CI: 0.89–1.19; P = .70).

Conclusion

Stage N3 of the 8th edition AJCC staging system for NPC is reasonable.

Level of Evidence

III Laryngoscope , 131:535–540, 2021

View Accepted Manuscript (Publisher)

Sponsoring Organization:: USDOE

OSTI ID:: 1633844

Journal Information:: Laryngoscope, Journal Name: Laryngoscope Journal Issue: 3 Vol. 131; ISSN 0023-852X

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: United States

Language:: English

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