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Title: NNA-DNA adducts as biomarkers for detecting exposure to thirdhand smoke

Patent ·
OSTI ID:1632461
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NNA-derived specific adducts represent an integrated biomarker of exposure to thirdhand smoke (THS) as NNA is unique to THS. The NNA-dG covalent binding adduct could serve as such a biomarker, and play a role in identifying individuals exposed to THS, thus providing critical information for early detection and prevention.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
10,538,549
Application Number:
14/659,588
OSTI ID:
1632461
Resource Relation:
Patent File Date: 03/16/2015
Country of Publication:
United States
Language:
English

References (5)

Thirdhand smoke causes DNA damage in human cells journal March 2013
8-Oxo-2′-deoxyguanosine as a biomarker of tobacco-smoking-induced oxidative stress journal August 2012
Tobacco-Specific Nitrosamine Detection Assays and Reagents patent-application February 2005
8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging journal October 1999
Formation of carcinogens indoors by surface-mediated reactions of nicotine with nitrous acid, leading to potential thirdhand smoke hazards journal February 2010

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