Phylogenomic Analyses of Non-Dikarya Fungi Supports Horizontal Gene Transfer Driving Diversification of Secondary Metabolism in the Amphibian Gastrointestinal Symbiont, Basidiobolus

Tabima, Javier F.; Trautman, Ian A.; Chang, Ying; Wang, Yan; Mondo, Stephen; Kuo, Alan; Salamov, Asaf; Grigoriev, Igor V.; Stajich, Jason E.; Spatafora, Joseph W.

doi:10.1534/g3.120.401516

Phylogenomic Analyses of Non-Dikarya Fungi Supports Horizontal Gene Transfer Driving Diversification of Secondary Metabolism in the Amphibian Gastrointestinal Symbiont, Basidiobolus

Journal Article · Wed Sep 02 00:00:00 EDT 2020 · G3

DOI:https://doi.org/10.1534/g3.120.401516· OSTI ID:1630619

^[1]; Trautman, Ian A. ^[1]; ^[1]; ^[2]; ^[3]; ^[3]; ^[3]; ^[4]; ^[2]; ^[1]

Oregon State Univ., Corvallis, OR (United States)
Univ. of California, Riverside, CA (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Research into secondary metabolism (SM) production by fungi has resulted in the discovery of diverse, biologically active compounds with significant medicinal applications. The fungi rich in SM production are taxonomically concentrated in the subkingdom Dikarya, which comprises the phyla Ascomycota and Basidiomycota. Here, we explore the potential for SM production in Mucoromycota and Zoopagomycota, two phyla of nonflagellated fungi that are not members of Dikarya, by predicting and identifying core genes and gene clusters involved in SM. The majority of non-Dikarya have few genes and gene clusters involved in SM production except for the amphibian gut symbionts in the genus Basidiobolus. Basidiobolus genomes exhibit an enrichment of SM genes involved in siderophore, surfactin-like, and terpene cyclase production, all these with evidence of constitutive gene expression. Gene expression and chemical assays also confirm that Basidiobolus has significant siderophore activity. Finally, the expansion of SMs in Basidiobolus are partially due to horizontal gene transfer from bacteria, likely as a consequence of its ecology as an amphibian gut endosymbiont.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1630619

Journal Information:: G3, Journal Name: G3 Journal Issue: 9 Vol. 10; ISSN 2160-1836

Publisher:: Genetics Society of AmericaCopyright Statement

Country of Publication:: United States

Language:: English

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Diploid-dominant life cycles characterize the early evolution of Fungi

Journal Article · Mon Aug 29 00:00:00 EDT 2022 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:1884334

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59 BASIC BIOLOGICAL SCIENCES
basidiobolus
horizontal gene transfer
metabolism
secondary
siderophores
zygomycetes

Supplemental Material for Tabima et al., 2020 Tabima, Javier; Trautman, Ian A.; Chang, Ying https://doi.org/10.25387/g3.12691859 The current record is supplemented by this dataset	dataset	January 2020
Supplemental Material for Tabima et al., 2020 Tabima, Javier; Trautman, Ian A.; Chang, Ying https://doi.org/10.25387/g3.12691859.v1 The current record is supplemented by this dataset	dataset	January 2020

Phylogenomic Analyses of Non-Dikarya Fungi Supports Horizontal Gene Transfer Driving Diversification of Secondary Metabolism in the Amphibian Gastrointestinal Symbiont, Basidiobolus

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