Therapeutic Targeting of Oncogenic Tyrosine Phosphatases
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August 2017 |
The Somatic Genomic Landscape of Glioblastoma
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October 2013 |
Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design
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December 1997 |
Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 Mutations
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June 2014 |
Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.
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February 1992 |
Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas
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March 2009 |
Measuring Ras-family GTP levels in vivo—running hot and cold
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October 2005 |
Protein Analysis by Hydrogen Exchange Mass Spectrometry
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June 2003 |
The Expression of Sprouty1, an Inhibitor of Fibroblast Growth Factor Signal Transduction, Is Decreased in Human Prostate Cancer
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July 2004 |
Sprouty 2, an Inhibitor of Mitogen-Activated Protein Kinase Signaling, Is Down-Regulated in Hepatocellular Carcinoma
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February 2006 |
Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase
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June 2007 |
Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling
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November 2003 |
Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases
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May 2017 |
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase
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May 1994 |
SHP2 sails from physiology to pathology
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October 2015 |
Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations
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March 2013 |
Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinoma
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December 2011 |
The Amber biomolecular simulation programs
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January 2005 |
Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases
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February 2006 |
Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia
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December 2004 |
Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains
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November 2001 |
The Ras/Mitogen-Activated Protein Kinase Pathway Inhibitor and Likely Tumor Suppressor Proteins, Sprouty 1 and Sprouty 2 Are Deregulated in Breast Cancer
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September 2004 |
Requirement of SHP2 Binding to Grb2-associated Binder-1 for Mitogen-activated Protein Kinase Activation in Response to Lysophosphatidic Acid and Epidermal Growth Factor
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April 2000 |
Sprouty genes function in suppression of prostate tumorigenesis
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November 2012 |
Phosphotyrosines 627 and 659 of Gab1 Constitute a Bisphosphoryl Tyrosine-based Activation Motif (BTAM) Conferring Binding and Activation of SHP2
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April 2001 |
Structural Basis for Substrate Specificity of Protein-tyrosine Phosphatase SHP-1
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February 2000 |
Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors
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journal
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January 2008 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
Visualization of the Cysteinyl-phosphate Intermediate of a Protein-tyrosine Phosphatase by X-ray Crystallography
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April 1998 |
Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2
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October 2018 |
Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition
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October 2018 |
Altering the Nucleophile Specificity of a Protein-tyrosine Phosphatase-catalyzed Reaction: PROBING THE FUNCTION OF THE INVARIANT GLUTAMINE RESIDUES
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March 1998 |
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
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October 2002 |
Sprouty-related Ena/Vasodilator-stimulated Phosphoprotein Homology 1-Domain-containing Protein (SPRED1), a Tyrosine-Protein Phosphatase Non-receptor Type 11 (SHP2) Substrate in the Ras/Extracellular Signal-regulated Kinase (ERK) Pathway
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journal
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April 2011 |
Shp2, an SH2-containing Protein-tyrosine Phosphatase, Positively Regulates Receptor Tyrosine Kinase Signaling by Dephosphorylating and Inactivating the Inhibitor Sprouty
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March 2004 |
NMRPipe: A multidimensional spectral processing system based on UNIX pipes
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November 1995 |
Functional Effects of PTPN11 (SHP2) Mutations Causing LEOPARD Syndrome on Epidermal Growth Factor-Induced Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase 3β Signaling
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March 2010 |
The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
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June 2003 |
Hydrogen exchange mass spectrometry for the analysis of protein dynamics
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January 2005 |
A Continuous Spectrophotometric and Fluorometric Assay for Protein Tyrosine Phosphatase Using Phosphotyrosine-Containing Peptides
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May 1993 |
Spred is a Sprouty-related suppressor of Ras signalling
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August 2001 |
MOLREP an Automated Program for Molecular Replacement
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December 1997 |
Semi-automated data processing of hydrogen exchange mass spectra using HX-Express
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December 2006 |
UCSF Chimera?A visualization system for exploratory research and analysis
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January 2004 |
Roles of Gab1 and SHP2 in Paxillin Tyrosine Dephosphorylation and Src Activation in Response to Epidermal Growth Factor
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December 2003 |
Crystal Structure of the Tyrosine Phosphatase SHP-2
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February 1998 |
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.
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May 1994 |
[20] Processing of X-ray diffraction data collected in oscillation mode
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book
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January 1997 |