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Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest

Journal Article · · Natural products and bioprospecting
 [1];  [2];  [2];  [3];  [4];  [5];  [5];  [2]
  1. Virginia Polytechnic Institute and State Univ. (Virginia Tech), Blacksburg, VA (United States); DOE/OSTI
  2. Virginia Polytechnic Institute and State Univ. (Virginia Tech), Blacksburg, VA (United States)
  3. Missouri Botanical Garden, St. Louis, MO (United States)
  4. Missouri Botanical Garden, Antananarivo (Madagascar)
  5. Centre National d’Application des Recherches Pharmaceutiques, Antananarivo (Madagascar)
+ Show Author Affiliations

Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins (1–3) and the known sesquiterpenoid cinnamosmolide (4). The structures of 1–3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 2, and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 2.8, 10.2 and 2.0 μM, respectively.

Research Organization:
Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division; Fogarty International Center; National Cancer Institute; National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Science Foundation (NSF)
Grant/Contract Number:
FG02-85ER13361
OSTI ID:
1629911
Journal Information:
Natural products and bioprospecting, Journal Name: Natural products and bioprospecting Journal Issue: 1 Vol. 6; ISSN 2192-2195
Publisher:
SpringerCopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (1)

A natural agonist of mosquito TRPA1 from the medicinal plant Cinnamosma fragrans that is toxic, antifeedant, and repellent to the yellow fever mosquito Aedes aegypti journal February 2018

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Cardiopteridacea
Leptaulus citroides
Triterpenoid saponins
antiproliferative activity