Efficacy of Female Rat Models in Translational Cardiovascular Aging Research

Rice, K. M.; Fannin, J. C.; Gillette, C.; Blough, E. R.

doi:10.1155/2014/153127

Efficacy of Female Rat Models in Translational Cardiovascular Aging Research

Journal Article · Tue Dec 31 23:00:00 EST 2013 · Journal of Aging Research

DOI:https://doi.org/10.1155/2014/153127· OSTI ID:1629803

Rice, K. M. ^[1]; Fannin, J. C. ^[2]; Gillette, C. ^[3]; Blough, E. R. ^[4]

Marshall Univ., Huntington, WV (United States). Robert C. Byrd Biotechnology Science Center. Center for Diagnostic Nanosystems; DOE/OSTI
Marshall Univ., Huntington, WV (United States). Robert C. Byrd Biotechnology Science Center. Center for Diagnostic Nanosystems; Marshall Univ., Huntington, WV (United States). Joan C. Edwards School of Medicine. Dept. of Pharmacology, Physiology and Toxicology
Marshall Univ., Huntington, WV (United States). School of Pharmacy. Dept. of Pharmacy Practice, Administration, and Research
Marshall Univ., Huntington, WV (United States). Robert C. Byrd Biotechnology Science Center. Center for Diagnostic Nanosystems; Marshall Univ., Huntington, WV (United States). Joan C. Edwards School of Medicine. Dept. of Pharmacology, Physiology and Toxicology; Marshall Univ., Huntington, WV (United States). School of Pharmacy. Dept. of Pharmaceutical Sciences and Research

Cardiovascular disease is the leading cause of death in women in the United States. Aging is a primary risk factor for the development of cardiovascular disease as well as cardiovascular-related morbidity and mortality. Aging is a universal process that all humans undergo; however, research in aging is limited by cost and time constraints. Therefore, most research in aging has been done in primates and rodents; however it is unknown how well the effects of aging in rat models translate into humans. To compound the complication of aging gender has also been indicated as a risk factor for various cardiovascular diseases. This review addresses the systemic pathophysiology of the cardiovascular system associated with aging and gender for aging research with regard to the applicability of rat derived data for translational application to human aging.

View Accepted Manuscript (DOE)

Research Organization:: Chicago Operations Office, Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

OSTI ID:: 1629803

Journal Information:: Journal of Aging Research, Journal Name: Journal of Aging Research Vol. 2014; ISSN 2090-2204

Publisher:: HindawiCopyright Statement

Country of Publication:: United States

Language:: English

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