The Bloom Syndrome Protein BLM Is Selectively Cleaved during Apoptotic Cell Death
Journal Article
·
· The Scientific World Journal (Online)
- Institut Pasteur (France). Unité Recombinaison et Expression Génétique. Dept. Retrovirus; DOE/OSTI
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division
- Institut Pasteur (France). Unité Recombinaison et Expression Génétique. Dept. Retrovirus
Bloom syndrome (BS) is an autosomal recessive disorder characterized by a high incidence of cancer and genomic instability. BLM, the protein defective in BS, is a RECQ-like helicase that is presumed to function in mammalian DNA replication, recombination or repair. Because of its importance in maintaining genomic stability, we asked whether BLM was among the proteins targeted for selective degradation during the execution phase of apoptosis as has been shown recently for PARP and ATM (1, 2), among others. We show here that BLM is rapidly cleaved in cells undergoing apoptosis.
- Sponsoring Organization:
- USDOE Office of Science (SC)
- DOE Contract Number:
- AC02-05CH11231
- OSTI ID:
- 1629619
- Journal Information:
- The Scientific World Journal (Online), Journal Name: The Scientific World Journal (Online) Vol. 1; ISSN 1537-744X
- Publisher:
- Hindawi
- Country of Publication:
- United States
- Language:
- English
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