Full-length HIV-1 immunogens induce greater T lymphocyte responses to conserved epitopes than conserved-region-only HIV-1 immunogens in monkeys

Journal Article · Thu Sep 13 00:00:00 EDT 2012 · Retrovirology

DOI:https://doi.org/10.1186/1742-4690-9-S2-O70· OSTI ID:1629349

Stephenson, K. E. ^[1]; SanMiguel, A. ^[2]; Simmons, N. L. ^[2]; Smith, K. ^[2]; Szinger, J. J. ^[3]; Korber, B. T. ^[3]; Barouch, D. H. ^[2]

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1. Harvard Medical School, Boston, MA (United States). Beth Israel Deaconess Medical Center; DOE/OSTI
2. Harvard Medical School, Boston, MA (United States). Beth Israel Deaconess Medical Center
3. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

A global HIV-1 vaccine will need to induce broadly reactive immune responses against conserved HIV-1 regions. It is currently unclear how best to elicit these responses by vaccination. We therefore compared the immunogenicity of a bivalent full-length HIV-1 Gag/Pol/Env mosaic vaccine, a trivalent full-length HIV-1 Gag/Pol/Env mosaic vaccine, and a bivalent mosaic vaccine containing only conserved HIV-1 Gag/Pol/Env epitopes in rhesus monkeys.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• Sponsoring Organization: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
• Grant/Contract Number: AC52-06NA25396
• OSTI ID: 1629349
• Journal Information: Retrovirology, Journal Name: Retrovirology Journal Issue: 2 Vol. 9; ISSN 1742-4690
• Publisher: BioMed Central
• Country of Publication: United States
• Language: English

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