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Comparison of the depth of vaccine-elicited HIV-1 Env epitope-specific CD8+ T lymphocyte responses

Journal Article · · Retrovirology
 [1];  [2];  [3];  [4];  [5];  [6];  [7];  [7];  [8];  [8];  [9];  [8]
  1. Beth Israel Deaconess Medical Center, Boston, MA (United States); DOE/OSTI
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  3. Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne (Switzerland)
  4. Sanofi Pasteur, Toronto, ON (Canada)
  5. Center for Infectious Diseases and Vaccinology, Tempe, AZ (United States)
  6. Centro Nacional de Biotecnologia, Madrid (Spain)
  7. Centro Nacional de Biotecnologia, Madrid (Spain)
  8. Beth Israel Deaconess Medical Center, Boston, MA (United States)
  9. Duke Univ., Durham, NC (United States). Medical Center. Duke Human Vaccine Inst.
+ Show Author Affiliations

One of the major challenges in the development of an effective HIV-1 vaccine is the extraordinary genetic diversity of the virus. Immunizations of nonhuman primates using consensus and mosaic immunogens have been shown to elicit cross-reactive CD8+T lymphocyte responses that increase the depth of epitope recognition. However, one of the limitations of vaccine-induced epitope-specific CD8+T lymphocytes includes lack of protection against diverse strains and emergent forms of HIV-1 due to altered T cell receptor (TCR) affinity for variant peptide:MHC class I complexes.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
Grant/Contract Number:
AC52-06NA25396
OSTI ID:
1629286
Journal Information:
Retrovirology, Journal Name: Retrovirology Journal Issue: S2 Vol. 9; ISSN 1742-4690
Publisher:
BioMed CentralCopyright Statement
Country of Publication:
United States
Language:
English

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