Protein Modifications as Potential Biomarkers in Breast Cancer

Jin, Hongjun; Zangar, Richard C.

doi:10.4137/bmi.s2557

Protein Modifications as Potential Biomarkers in Breast Cancer

Journal Article · Sun Nov 29 23:00:00 EST 2009 · Biomarker Insights

DOI:https://doi.org/10.4137/bmi.s2557· OSTI ID:1629199

Jin, Hongjun ^[1]; Zangar, Richard C. ^[2]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Cell Biology and Biochemistry Group; DOE/OSTI
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Cell Biology and Biochemistry Group

A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry techniques have shown promise for identifying changes in PTMs. In this review, we summarize the current literature on PTMs identified in the plasma and tumor tissue of breast-cancer patients or in breast cell lines. We also discuss some of the analytical techniques currently being used to evaluate PTMs.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division; National Institutes of Health (NIH)

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1629199

Journal Information:: Biomarker Insights, Journal Name: Biomarker Insights Vol. 4; ISSN 1177-2719

Publisher:: SAGECopyright Statement

Country of Publication:: United States

Language:: English

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