Simultaneous TMS-fMRI of the Visual Cortex Reveals Functional Network, Even in Absence of Phosphene Sensation

Caparelli, E. C.; Backus, W.; Telang, F.; Wang, G-J; Maloney, T.; Goldstein, R. Z.; Anschel, D.; Henn, F.

doi:10.2174/1874440001004010100

Simultaneous TMS-fMRI of the Visual Cortex Reveals Functional Network, Even in Absence of Phosphene Sensation

Journal Article · Thu Aug 12 00:00:00 EDT 2010 · The Open Neuroimaging Journal

DOI:https://doi.org/10.2174/1874440001004010100· OSTI ID:1629133

Caparelli, E. C. ^[1]; Backus, W. ^[2]; Telang, F. ^[3]; Wang, G-J ^[4]; Maloney, T. ^[4]; Goldstein, R. Z. ^[4]; Anschel, D. ^[5]; Henn, F. ^[4]

Brookhaven National Lab. (BNL), Upton, NY (United States). Medical Dept.; Stony Brook Univ., NY (United States). SCAN Center; DOE/OSTI
Stony Brook Univ., NY (United States). Dept. of Anesthesiology
National Inst. on Alcohol Abuse and Alcoholism, Bethesda, MD (United States)
Brookhaven National Lab. (BNL), Upton, NY (United States). Medical Dept.
St. Charles Hospital, Port Jefferson, NY (United States); National Inst. on Alcohol Abuse and Alcoholism, Bethesda, MD (United States)

Phosphene sensation is commonly used to measure cortical excitability during transcranial magnetic stimulation (TMS) of the occipital cortex. However, some individuals lack this perception, and the reason for it is still unknown. In this work, we used functional magnetic resonance imaging (fMRI) to detect brain activation during local TMS of the occipital cortex in twelve healthy subjects. We found that TMS modulated brain activity in areas connected to the stimulation site, even in people unable to see phosphene. However, we observed a trend for a lower bloodoxygenation-level dependent (BOLD) signal, and smaller brain-activation clusters near the stimulated site than in the interconnected brain areas, suggesting that TMS pulse is more effective downstream than at its application site. Furthermore, we noted prominent differences in brain activation/deactivation patterns between subjects who perceived phosphene and those who did not, implying a functional distinction in their neuronal networks that might explain the origin of differences in phosphene generation.

View Accepted Manuscript (DOE)

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-98CH10886

OSTI ID:: 1629133

Journal Information:: The Open Neuroimaging Journal, Journal Name: The Open Neuroimaging Journal Vol. 4; ISSN 1874-4400

Publisher:: Bentham OpenCopyright Statement

Country of Publication:: United States

Language:: English

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