Cancer–Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer

Sebastian, Aimy; Hum, Nicholas; Hudson, Bryan; Loots, Gabriela

doi:10.3390/microarrays4040503

Cancer–Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer

Journal Article · Thu Oct 29 00:00:00 EDT 2015 · Microarrays

DOI:https://doi.org/10.3390/microarrays4040503· OSTI ID:1629044

Sebastian, Aimy ^[1]; Hum, Nicholas ^[2]; Hudson, Bryan ^[2]; Loots, Gabriela ^[3]

Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); University of California, Merced, CA (United States); DOE/OSTI
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); University of California, Merced, CA (United States)

Dynamic interaction between prostate cancer and the bone microenvironment is a major contributor to metastasis of prostate cancer to bone. In this study, we utilized an in vitro co-culture model of PC3 prostate cancer cells and osteoblasts followed by microarray based gene expression profiling to identify previously unrecognized prostate cancer–bone microenvironment interactions. Factors secreted by PC3 cells resulted in the up-regulation of many genes in osteoblasts associated with bone metabolism and cancer metastasis, including Mmp13, Il-6 and Tgfb2, and down-regulation of Wnt inhibitor Sost. To determine whether altered Sost expression in the bone microenvironment has an effect on prostate cancer metastasis, we co-cultured PC3 cells with Sost knockout (Sost^KO) osteoblasts and wildtype (WT) osteoblasts and identified several genes differentially regulated between PC3-Sost^KO osteoblast co-cultures and PC3-WT osteoblast co-cultures. Co-culturing PC3 cells with WT osteoblasts up-regulated cancer-associated long noncoding RNA (lncRNA) MALAT1 in PC3 cells. MALAT1 expression was further enhanced when PC3 cells were co-cultured with Sost^KO osteoblasts and treatment with recombinant Sost down-regulated MALAT1 expression in these cells. Our results suggest that reduced Sost expression in the tumor microenvironment may promote bone metastasis by up-regulating MALAT1 in prostate cancer.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: UC Davis Cancer Center; USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 1629044

Journal Information:: Microarrays, Journal Name: Microarrays Journal Issue: 4 Vol. 4; ISSN 2076-3905; ISSN MICRHK

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

References (75)

LRP 5 knockdown: effect on prostate cancer invasion growth and skeletal metastasis in vitro and in vivo Rabbani, Shafaat A.; Arakelian, Ani; Farookhi, Riaz Cancer Medicine, Vol. 2, Issue 5 https://doi.org/10.1002/cam4.111	journal	September 2013
Dynamic process of prostate cancer metastasis to bone Tantivejkul, Kwanchanit; Kalikin, Linda M.; Pienta, Kenneth J. Journal of Cellular Biochemistry, Vol. 91, Issue 4 https://doi.org/10.1002/jcb.10664	journal	January 2004
Dynamic interaction between breast cancer cells and osteoblastic tissue: Comparison of Two- and Three-dimensional cultures Krishnan, Venkatesh; Shuman, Laurie A.; Sosnoski, Donna M. Journal of Cellular Physiology, Vol. 226, Issue 8 https://doi.org/10.1002/jcp.22550	journal	April 2011
C/EBPβ binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells Henriquez, Berta; Hepp, Matias; Merino, Paola Journal of Cellular Physiology, Vol. 226, Issue 11 https://doi.org/10.1002/jcp.22652	journal	August 2011
Chemokine (C-C Motif) Ligand 5 is Involved in Tumor-Associated Dendritic Cell-Mediated Colon Cancer Progression Through Non-Coding RNA MALAT-1: CCL5-MEDIATED SIGNALING IN COLON CANCER Kan, Jung-Yu; Wu, Deng-Chyang; Yu, Fang-Jung Journal of Cellular Physiology, Vol. 230, Issue 8 https://doi.org/10.1002/jcp.24918	journal	April 2015
Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo: OSTEOACTIVIN ENHANCES BONE FORMATION Frara, Nagat; Abdelmagid, Samir M.; Sondag, Gregory R. Journal of Cellular Physiology, Vol. 231, Issue 1 https://doi.org/10.1002/jcp.25020	journal	September 2015
MALAT1 — a paradigm for long noncoding RNA function in cancer Gutschner, Tony; Hämmerle, Monika; Diederichs, Sven Journal of Molecular Medicine, Vol. 91, Issue 7 https://doi.org/10.1007/s00109-013-1028-y	journal	March 2013
Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer Hardaway, Aimalie L.; Herroon, Mackenzie K.; Rajagurubandara, Erandi Clinical & Experimental Metastasis, Vol. 32, Issue 4 https://doi.org/10.1007/s10585-015-9714-5	journal	March 2015
Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation Lai, Ming-chun; Yang, Zhe; Zhou, Lin Medical Oncology, Vol. 29, Issue 3 https://doi.org/10.1007/s12032-011-0004-z	journal	June 2011
MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway Dong, Yongqiang; Liang, Guojun; Yuan, Bo Tumor Biology, Vol. 36, Issue 3 https://doi.org/10.1007/s13277-014-2631-4	journal	November 2014
Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13 Lin, Yun-Hua; Tian, Yong; Wang, Jun-Sheng Tumor Biology, Vol. 37, Issue 12 https://doi.org/10.1007/s13277-015-3796-1	journal	July 2015
17β-Estradiol treatment inhibits breast cell proliferation, migration and invasion by decreasing MALAT-1 RNA level Zhao, Ziyi; Chen, Changjin; Liu, Yu Biochemical and Biophysical Research Communications, Vol. 445, Issue 2 https://doi.org/10.1016/j.bbrc.2014.02.006	journal	March 2014
A critical role for interleukin-6 family-mediated Stat3 activation in osteoblast differentiation and bone formation Itoh, Shousaku; Udagawa, Nobuyuki; Takahashi, Naoyuki Bone, Vol. 39, Issue 3 https://doi.org/10.1016/j.bone.2006.02.074	journal	September 2006
New insights into NPP1 function: Lessons from clinical and animal studies Mackenzie, N. C. W.; Huesa, C.; Rutsch, F. Bone, Vol. 51, Issue 5 https://doi.org/10.1016/j.bone.2012.07.014	journal	November 2012
The LIM-only protein FHL2 controls mesenchymal cell osteogenic differentiation and bone formation through Wnt5a and Wnt10b Brun, Julia; Fromigué, Olivia; Dieudonné, François-Xavier Bone, Vol. 53, Issue 1 https://doi.org/10.1016/j.bone.2012.11.020	journal	March 2013
Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression Varambally, Sooryanarayana; Yu, Jianjun; Laxman, Bharathi Cancer Cell, Vol. 8, Issue 5 https://doi.org/10.1016/j.ccr.2005.10.001	journal	November 2005
A unified model for bone–renal mineral and energy metabolism Rowe, Peter S. Current Opinion in Pharmacology, Vol. 22 https://doi.org/10.1016/j.coph.2015.03.006	journal	June 2015
MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes Tano, Keiko; Mizuno, Rie; Okada, Tomoko FEBS Letters, Vol. 584, Issue 22 https://doi.org/10.1016/j.febslet.2010.10.008	journal	October 2010
Long Noncoding RNA MALAT-1 is a New Potential Therapeutic Target for Castration Resistant Prostate Cancer Ren, Shancheng; Liu, Yawei; Xu, Weidong Journal of Urology, Vol. 190, Issue 6 https://doi.org/10.1016/j.juro.2013.07.001	journal	December 2013
The critical role of the bone microenvironment in cancer metastases Casimiro, Sandra; Guise, Theresa A.; Chirgwin, John Molecular and Cellular Endocrinology, Vol. 310, Issue 1-2 https://doi.org/10.1016/j.mce.2009.07.004	journal	October 2009
The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation Tripathi, Vidisha; Ellis, Jonathan D.; Shen, Zhen Molecular Cell, Vol. 39, Issue 6 https://doi.org/10.1016/j.molcel.2010.08.011	journal	September 2010
New therapeutic targets for cancer bone metastasis Krzeszinski, Jing Y.; Wan, Yihong Trends in Pharmacological Sciences, Vol. 36, Issue 6 https://doi.org/10.1016/j.tips.2015.04.006	journal	June 2015
Proteases, growth factors, chemokines, and the microenvironment in prostate cancer bone metastasis Bonfil, R. Daniel; Chinni, Sreenivasa; Fridman, Rafael Urologic Oncology: Seminars and Original Investigations, Vol. 25, Issue 5 https://doi.org/10.1016/j.urolonc.2007.05.008	journal	September 2007
Wnt and Wnt inhibitors in bone metastasis Sottnik, Joseph L.; Hall, Christopher L.; Zhang, Jian BoneKEy Reports, Vol. 1, Issue 7 https://doi.org/10.1038/bonekey.2012.101	journal	July 2012
Osteoblasts in prostate cancer metastasis to bone Logothetis, Christopher J.; Lin, Sue-Hwa Nature Reviews Cancer, Vol. 5, Issue 1 https://doi.org/10.1038/nrc1528	journal	January 2005
Comparative transcriptomic analysis reveals conserved programmes underpinning organogenesis and reproduction in land plants Julca, Irene; Ferrari, Camilla; Flores-Tornero, María Nature Plants, Vol. 7, Issue 8 https://doi.org/10.1038/s41477-021-00958-2	journal	July 2021
Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis Rodriguez-Fraticelli, Alejo E.; Weinreb, Caleb; Wang, Shou-Wen Nature, Vol. 583, Issue 7817 https://doi.org/10.1038/s41586-020-2503-6	journal	July 2020
Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition Ying, Liang; Chen, Qi; Wang, Yawei Molecular BioSystems, Vol. 8, Issue 9 https://doi.org/10.1039/c2mb25070e	journal	January 2012
Targeted deletion of Sost distal enhancer increases bone formation and bone mass Collette, N. M.; Genetos, D. C.; Economides, A. N. Proceedings of the National Academy of Sciences, Vol. 109, Issue 35 https://doi.org/10.1073/pnas.1207188109	journal	August 2012
Microarray and Proteomic Analysis of Breast Cancer Cell and Osteoblast Co-cultures: ROLE OF OSTEOBLAST MATRIX METALLOPROTEINASE (MMP)-13 IN BONE METASTASIS Morrison, Charlotte; Mancini, Stephanie; Cipollone, Jane Journal of Biological Chemistry, Vol. 286, Issue 39 https://doi.org/10.1074/jbc.m111.222513	journal	July 2011
Silencing of Long Noncoding RNA MALAT1 by miR-101 and miR-217 Inhibits Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Wang, Xinyu; Li, Meng; Wang, Zhiqiong Journal of Biological Chemistry, Vol. 290, Issue 7 https://doi.org/10.1074/jbc.m114.596866	journal	December 2014
Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects Kenner, Lukas; Hoebertz, Astrid; Beil, F. Timo Journal of Cell Biology, Vol. 164, Issue 4 https://doi.org/10.1083/jcb.200308155	journal	February 2004
Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion Guo, F.; Li, Y.; Liu, Y. Acta Biochimica et Biophysica Sinica, Vol. 42, Issue 3 https://doi.org/10.1093/abbs/gmq008	journal	February 2010
Exploration, normalization, and summaries of high density oligonucleotide array probe level data Irizarry, Rafael A.; Hobbs, Bridget; Collin, Francois Biostatistics, Vol. 4, Issue 2, p. 249-264 https://doi.org/10.1093/biostatistics/4.2.249	journal	April 2003
Perturbation-based gene regulatory network inference to unravel oncogenic mechanisms Morgan, Daniel; Studham, Matthew; Tjärnberg, Andreas Scientific Reports https://doi.org/10.1101/735514	journal	October 2019
Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks Shannon, P. Genome Research, Vol. 13, Issue 11 https://doi.org/10.1101/gr.1239303	journal	November 2003
ADAMs in cancer cell proliferation and progression Mochizuki, Satsuki; Okada, Yasunori Cancer Science, Vol. 98, Issue 5 https://doi.org/10.1111/j.1349-7006.2007.00434.x	journal	May 2007
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells Florencio-Silva, Rinaldo; Sasso, Gisela Rodrigues da Silva; Sasso-Cerri, Estela BioMed Research International, Vol. 2015 https://doi.org/10.1155/2015/421746	journal	January 2015
Stromal Expression of Connective Tissue Growth Factor Promotes Angiogenesis and Prostate Cancer Tumorigenesis Yang, Feng; Tuxhorn, Jennifer A.; Ressler, Steven J. Cancer Research, Vol. 65, Issue 19 https://doi.org/10.1158/0008-5472.can-05-1702	journal	October 2005
Transcriptome and de novo analysis of Rosa xanthina f. spontanea in response to cold stress Zhuang, Defeng; Ma, Ce; Xue, Li BMC Plant Biology, Vol. 21, Issue 1 https://doi.org/10.1186/s12870-021-03246-5	journal	October 2021
Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver Mendonsa, Alisha M.; VanSaun, Michael N.; Ustione, Alessandro Molecular Cancer, Vol. 14, Issue 1 https://doi.org/10.1186/s12943-014-0282-0	journal	January 2015
Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma Hu, Liwen; Wu, Yuanyuan; Tan, Deli Journal of Experimental & Clinical Cancer Research, Vol. 34, Issue 1 https://doi.org/10.1186/s13046-015-0123-z	journal	January 2015
The Chemokine Cxcl1 Is a Novel Target Gene of Parathyroid Hormone (PTH)/PTH-Related Protein in Committed Osteoblasts Onan, Döne; Allan, Elizabeth H.; Quinn, Julian M. W. Endocrinology, Vol. 150, Issue 5 https://doi.org/10.1210/en.2008-1597	journal	January 2009
Phosphate-Dependent Regulation of MGP in Osteoblasts: Role of ERK1/2 and Fra-1 Julien, Marion; Khoshniat, Solmaz; Lacreusette, Aline Journal of Bone and Mineral Research, Vol. 24, Issue 11 https://doi.org/10.1359/jbmr.090508	journal	November 2009
Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB Tripathi, Vidisha; Shen, Zhen; Chakraborty, Arindam PLoS Genetics, Vol. 9, Issue 3 https://doi.org/10.1371/journal.pgen.1003368	journal	March 2013
An MMP13-Selective Inhibitor Delays Primary Tumor Growth and the Onset of Tumor-Associated Osteolytic Lesions in Experimental Models of Breast Cancer Shah, Manisha; Huang, Dexing; Blick, Tony PLoS ONE, Vol. 7, Issue 1 https://doi.org/10.1371/journal.pone.0029615	journal	January 2012
Global Gene Expression Analysis of the Interaction between Cancer Cells and Osteoblasts to Predict Bone Metastasis in Breast Cancer Rajski, Michal; Vogel, Brigitte; Baty, Florent PLoS ONE, Vol. 7, Issue 1 https://doi.org/10.1371/journal.pone.0029743	journal	January 2012
Matrix Metalloproteinase 13 (MMP13) Is a Direct Target of Osteoblast-Specific Transcription Factor Osterix (Osx) in Osteoblasts Zhang, Chi; Tang, Wanjin; Li, Yang PLoS ONE, Vol. 7, Issue 11 https://doi.org/10.1371/journal.pone.0050525	journal	November 2012
Wise Regulates Bone Deposition through Genetic Interactions with Lrp5 Ellies, Debra L.; Economou, Androulla; Viviano, Beth PLoS ONE, Vol. 9, Issue 5 https://doi.org/10.1371/journal.pone.0096257	journal	May 2014
Emerging roles of chemokines in prostate cancer Vindrieux, David; Escobar, Pauline; Lazennec, Gwendal Endocrine-Related Cancer, Vol. 16, Issue 3 https://doi.org/10.1677/erc-09-0109	journal	September 2009
Osteoblast-derived WISP-1 increases VCAM-1 expression and enhances prostate cancer metastasis by down-regulating miR-126 Tai, Huai-Ching; Chang, An-Chen; Yu, Hong-Jeng Oncotarget, Vol. 5, Issue 17 https://doi.org/10.18632/oncotarget.2280	journal	July 2014
Bioconductor : open software development for computational biology and bioinformatics C., Gentleman, Robert; J., Carey, Vincent; M., Bates, Douglas BioMed Central https://doi.org/10.21256/zhaw-1907	text	January 2004
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments Smyth, Gordon K. Statistical Applications in Genetics and Molecular Biology, Vol. 3, Issue 1 https://doi.org/10.2202/1544-6115.1027	journal	January 2004
MALAT-1: A long non-coding RNA and its important 3' end functional motif in colorectal cancer metastasis Li, Zuguo International Journal of Oncology https://doi.org/10.3892/ijo.2011.1007	journal	April 2011
Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer Jiao, Feng; Hu, Hai; Yuan, Cuncun Oncology Reports, Vol. 32, Issue 6 https://doi.org/10.3892/or.2014.3518	journal	September 2014
MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway Wu, Xiang-Song; Wang, Xu-An; Wu, Wen-Guang Cancer Biology & Therapy, Vol. 15, Issue 6 https://doi.org/10.4161/cbt.28584	journal	March 2014
Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance Tang, Simon Y.; Herber, Ralf-Peter; Ho, Sunita P. Journal of Bone and Mineral Research, Vol. 27, Issue 9 https://doi.org/10.1002/jbmr.1646	journal	August 2012
Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation Zhao, Lan; Huang, Jian; Guo, Ruolin Journal of Bone and Mineral Research, Vol. 25, Issue 6 https://doi.org/10.1002/jbmr.28	journal	January 2010
Phenotypic differences in subclones and long-term cultures of clonally derived rat bone cell lines Bellows, Carlton G.; Sodek, Jaro; Yao, Kam-Ling Journal of Cellular Biochemistry, Vol. 31, Issue 2 https://doi.org/10.1002/jcb.240310207	journal	January 1986
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method Livak, Kenneth J.; Schmittgen, Thomas D. Methods, Vol. 25, Issue 4 https://doi.org/10.1006/meth.2001.1262	journal	December 2001
TGF-β in the Bone Microenvironment: Role in Breast Cancer Metastases Buijs, Jeroen T.; Stayrook, Keith R.; Guise, Theresa A. Cancer Microenvironment, Vol. 4, Issue 3 https://doi.org/10.1007/s12307-011-0075-6	journal	July 2011
Effect of osteoblast supernatants on cancer cell migration and invasion Giunciuglio, Daniela; Cai, Tania; Filanti, Cristina Cancer Letters, Vol. 97, Issue 1 https://doi.org/10.1016/0304-3835(95)03955-V	journal	October 1995
The effects of cytokines and growth factors on osteoblastic cells Mundy, G. R.; Boyce, B.; Hughes, D. Bone, Vol. 17, Issue 2 https://doi.org/10.1016/8756-3282(95)00182-D	journal	August 1995
Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions Akech, J.; Wixted, J. J.; Bedard, K. Oncogene, Vol. 29, Issue 6 https://doi.org/10.1038/onc.2009.389	journal	November 2009
Microarray and Proteomic Analysis of Breast Cancer Cell and Osteoblast Co-cultures: ROLE OF OSTEOBLAST MATRIX METALLOPROTEINASE (MMP)-13 IN BONE METASTASIS Morrison, Charlotte; Mancini, Stephanie; Cipollone, Jane Journal of Biological Chemistry, Vol. 286, Issue 39 https://doi.org/10.1074/jbc.M111.222513	journal	July 2011
Silencing of Long Noncoding RNA MALAT1 by miR-101 and miR-217 Inhibits Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Wang, Xinyu; Li, Meng; Wang, Zhiqiong Journal of Biological Chemistry, Vol. 290, Issue 7 https://doi.org/10.1074/jbc.M114.596866	journal	December 2014
ToppGene Suite for gene list enrichment analysis and candidate gene prioritization Chen, J.; Bardes, E. E.; Aronow, B. J. Nucleic Acids Research, Vol. 37, Issue Web Server https://doi.org/10.1093/nar/gkp427	journal	May 2009
Sclerostin: recent advances and clinical implications Honasoge, Mahalakshmi; Rao, Ajay D.; Rao, Sudhaker D. Current Opinion in Endocrinology & Diabetes and Obesity, Vol. 21, Issue 6 https://doi.org/10.1097/MED.0000000000000114	journal	January 2014
Stromal Expression of Connective Tissue Growth Factor Promotes Angiogenesis and Prostate Cancer Tumorigenesis Yang, Feng; Tuxhorn, Jennifer A.; Ressler, Steven J. Cancer Research, Vol. 65, Issue 19 https://doi.org/10.1158/0008-5472.CAN-05-1702	journal	October 2005
Matrix Metalloproteinase (MMP)-13 Regulates Mammary Tumor–Induced Osteolysis by Activating MMP9 and Transforming Growth Factor-β Signaling at the Tumor-Bone Interface Nannuru, Kalyan C.; Futakuchi, Mitsuru; Varney, Michelle L. Cancer Research, Vol. 70, Issue 9 https://doi.org/10.1158/0008-5472.CAN-09-3251	journal	April 2010
Bioconductor: open software development for computational biology and bioinformatics Gentleman, Robert C.; Carey, Vincent J.; Bates, Douglas M. Genome Biology, Vol. 5, Issue 10, p. R80 https://doi.org/10.1186/gb-2004-5-10-r80	journal	September 2004
GeneMANIA: Fast gene network construction and function prediction for Cytoscape Montojo, Jason; Zuberi, Khalid; Rodriguez, Harold F1000Research, Vol. 3 https://doi.org/10.12688/f1000research.4572.1	journal	January 2014
The Role of Connective Tissue Growth Factor (CTGF/CCN2) in Skeletogenesis Arnott, John A.; Lambi, Alex G.; Mundy, Christina Critical Reviews™ in Eukaryotic Gene Expression, Vol. 21, Issue 1 https://doi.org/10.1615/CritRevEukarGeneExpr.v21.i1.40	journal	January 2011
Emerging roles of chemokines in prostate cancer Vindrieux, David; Escobar, Pauline; Lazennec, Gwendal Endocrine-Related Cancer, Vol. 16, Issue 3 https://doi.org/10.1677/ERC-09-0109	journal	September 2009
Cancer statistics, 2013 Siegel, Rebecca; Naishadham, Deepa; Jemal, Ahmedin CA: A Cancer Journal for Clinicians, Vol. 63, Issue 1 https://doi.org/10.3322/caac.21166	journal	January 2013

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Cancer–Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer

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