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Improving pandemic influenza risk assessment

Journal Article · · eLife
DOI:https://doi.org/10.7554/elife.03883· OSTI ID:1628823
 [1];  [2];  [3];  [4];  [5];  [6];  [7];  [8];  [8];  [8];  [5];  [9];  [10];  [11];  [6];  [5];  [12];  [8];  [13];  [6] more »;  [8];  [6];  [14];  [8];  [8];  [6];  [15];  [16] « less
  1. University of Cambridge, Cambridge (United Kingdom). Department of Veterinary Medicine; DOE/OSTI
  2. University of Virginia, Charlottesville (United States).Department of Biomedical Engineering
  3. Centers for Disease Control and Prevention, Atlanta (United States). Influenza Division
  4. School of Public Health, Imperial College London, London (United Kingdom). Department of Infectious Disease Epidemiology
  5. Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Bioscience Division
  6. National Institutes of Health, Bethesda, MD (United States). Fogarty International Center
  7. Department of Health and Human Services, Washington (United States). Division of Analytic Decision Support, Biomedical Advanced Research and Development Authority
  8. Centers for Disease Control and Prevention (CDC), Atlanta, GA (United States). Influenza Div.
  9. Univ. of Oxford (United Kingdom). Spatial Ecology and Epidemiology Group, Department of Zoology
  10. Erasmus Medical Center, Rotterdam (Netherlands). Department of Viroscience, Postgraduate School of Molecular Medicine
  11. Univ. of Cambridge (United Kingdom). Department of Zoology
  12. Agency for Science Technology and Research, Singapore (Singapore). Bioinformatics Institute
  13. Cornell University, Ithaca, NY (United States). James A Baker Institute, College of Veterinary Medicine
  14. United States Department of Agriculture, Athens, GA (United States). Exotic and Emerging Avian Viral Diseases Research Unit, Southeast Poultry Research Laboratories
  15. Harvard School of Public Health, Boston, MA (United States). Center for Communicable Disease Dynamics, Department of Epidemiology
  16. Fred Hutchinson Cancer Research Center, Seattle, WA (United States). Division of Basic Sciences
+ Show Author Affiliations

Assessing the pandemic risk posed by specific non-human influenza A viruses is an important goal in public health research. As influenza virus genome sequencing becomes cheaper, faster, and more readily available, the ability to predict pandemic potential from sequence data could transform pandemic influenza risk assessment capabilities. However, the complexities of the relationships between virus genotype and phenotype make such predictions extremely difficult. The integration of experimental work, computational tool development, and analysis of evolutionary pathways, together with refinements to influenza surveillance, has the potential to transform our ability to assess the risks posed to humans by non-human influenza viruses and lead to improved pandemic preparedness and response.

Research Organization:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE; US Dept. of Homeland Security; National Inst. of Health, US Dept. of Agriculture
Grant/Contract Number:
AC52-06NA25396
OSTI ID:
1628823
Journal Information:
eLife, Journal Name: eLife Vol. 3; ISSN 2050-084X
Publisher:
eLife Sciences Publications, Ltd.Copyright Statement
Country of Publication:
United States
Language:
English

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Cited By (20)

Tackling viral haemorrhagic fever in Africa journal December 2017
Evidence for history-dependence of influenza pandemic emergence journal March 2017
Infectious Diseases Society of America and Gain-of-Function Experiments With Pathogens Having Pandemic Potential journal September 2015
Fitness Inference from Short-Read Data: Within-Host Evolution of a Reassortant H5N1 Influenza Virus journal August 2015
The Geographic Variation of Surveillance and Zoonotic Spillover Potential of Influenza Viruses in Domestic Poultry and Swine journal November 2018
Cross-scale dynamics and the evolutionary emergence of infectious diseases journal April 2020
Reply to “Studies on Influenza Virus Transmission between Ferrets: the Public Health Risks Revisited” journal February 2015
Can Limited Scientific Value of Potential Pandemic Pathogen Experiments Justify the Risks? journal October 2014
Moratorium on Research Intended To Create Novel Potential Pandemic Pathogens journal December 2014
Use of Highly Pathogenic Avian Influenza A(H5N1) Gain-Of-Function Studies for Molecular-Based Surveillance and Pandemic Preparedness journal December 2014
Respiratory Mononuclear Phagocytes in Human Influenza A Virus Infection: Their Role in Immune Protection and As Targets of the Virus journal July 2018
Advances in Visualization Tools for Phylogenomic and Phylodynamic Studies of Viral Diseases journal August 2019
Influenza A Hemagglutinin Passage Bias Sites and Host Specificity Mutations journal August 2019
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Epidemiological and Immunological Features of Influenza Viruses in Hospitalized Children with Influenza Illness in Hangzhou journal July 2019

Figures / Tables (3)

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