Phosphoprotein SAK1 is a regulator of acclimation to singlet oxygen in Chlamydomonas reinhardtii

Wakao, Setsuko; Chin, Brian L.; Ledford, Heidi K.; Dent, Rachel M.; Casero, David; Pellegrini, Matteo; Merchant, Sabeeha S.; Niyogi, Krishna K.

doi:10.7554/elife.02286

Phosphoprotein SAK1 is a regulator of acclimation to singlet oxygen in Chlamydomonas reinhardtii

Journal Article · Fri May 23 00:00:00 EDT 2014 · eLife

DOI:https://doi.org/10.7554/elife.02286· OSTI ID:1628809

Wakao, Setsuko ^[1]; Chin, Brian L. ^[2]; Ledford, Heidi K. ^[2]; Dent, Rachel M. ^[3]; Casero, David ^[4]; Pellegrini, Matteo ^[5]; Merchant, Sabeeha S. ^[6]; Niyogi, Krishna K. ^[7]

Univ. of California, Berkeley, CA (United States). Dept. of Plant and Microbial Biology; DOE/OSTI
Univ. of California, Berkeley, CA (United States). Dept. of Plant and Microbial Biology
Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, United States
Univ. of California, Los Angeles, CA (United States). Dept. of Molecular, Cell and Developmental Biology
Univ. of California, Los Angeles, CA (United States). Dept. of Molecular, Cell and Developmental Biology; Univ. of California, Los Angeles, CA (United States). Inst. for Genomics and Proteomics
Univ. of California, Los Angeles, CA (United States). Inst. for Genomics and Proteomics; Univ. of California, Los Angeles, CA (United States). Dept. of Chemistry and Biochemistry
Univ. of California, Berkeley, CA (United States). Dept. of Plant and Microbial Biology; Univ. of California, Berkeley, CA (United States). Howard Hughes Medical Inst.; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Physical Biosciences Division

Singlet oxygen is a highly toxic and inevitable byproduct of oxygenic photosynthesis. The unicellular green alga Chlamydomonas reinhardtii is capable of acclimating specifically to singlet oxygen stress, but the retrograde signaling pathway from the chloroplast to the nucleus mediating this response is unknown. Here we describe a mutant, singlet oxygen acclimation knocked-out 1 (sak1), that lacks the acclimation response to singlet oxygen. Analysis of genome-wide changes in RNA abundance during acclimation to singlet oxygen revealed that SAK1 is a key regulator of the gene expression response during acclimation. The SAK1 gene encodes an uncharacterized protein with a domain conserved among chlorophytes and present in some bZIP transcription factors. The SAK1 protein is located in the cytosol, and it is induced and phosphorylated upon exposure to singlet oxygen, suggesting that it is a critical intermediate component of the retrograde signal transduction pathway leading to singlet oxygen acclimation.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division; Gordon and Betty Moore Foundation; National Institutes of Health (NIH)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1628809

Journal Information:: eLife, Journal Name: eLife Vol. 3; ISSN 2050-084X

Publisher:: eLife Sciences Publications, Ltd.Copyright Statement

Country of Publication:: United States

Language:: English

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Arabidopsis mutants reveal multiple singlet oxygen signaling pathways involved in stress response and development Baruah, Aiswarya; Šimková, Klára; Apel, Klaus ETH Zurich https://doi.org/10.3929/ethz-b-000088003	text	January 2009
Characterization of soldat8, a Suppressor of Singlet Oxygen-Induced Cell Death in Arabidopsis Seedlings Coll, Nuria S.; Danon, Antoine; Meurer, Joerg ETH Zurich https://doi.org/10.3929/ethz-b-000113271	text	January 2009

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Characterization of Ferredoxin-Dependent Biliverdin Reductase PCYA1 Reveals the Dual Function in Retrograde Bilin Biosynthesis and Interaction With Light-Dependent Protochlorophyllide Oxidoreductase LPOR in Chlamydomonas reinhardtii Zhang, Weiqing; Zhong, Huan; Lu, Hui Frontiers in Plant Science, Vol. 9 https://doi.org/10.3389/fpls.2018.00676	journal	May 2018
Data from: Phosphoprotein SAK1 is a regulator of acclimation to singlet oxygen in Chlamydomonas reinhardtii Wakao, Setsuko; Chin, Brian L.; Niyogi, Krishna K. Dryad https://doi.org/10.5061/dryad.h7pm2	dataset	January 2015
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Light stress and photoprotection in Chlamydomonas reinhardtii Erickson, Erika; Wakao, Setsuko; Niyogi, Krishna K. The Plant Journal, Vol. 82, Issue 3 https://doi.org/10.1111/tpj.12825	journal	March 2015
When Unity Is Strength: The Strategies Used by Chlamydomonas to Survive Environmental Stresses de Carpentier, Félix; Lemaire, Stéphane D.; Danon, Antoine Cells, Vol. 8, Issue 11 https://doi.org/10.3390/cells8111307	journal	October 2019

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Phosphoprotein SAK1 is a regulator of acclimation to singlet oxygen in Chlamydomonas reinhardtii

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