Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014–2019

Martinez, Bridget; Peplow, Philip V.

doi:10.4103/1673-5374.272572

Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014–2019

Journal Article · Thu Jan 09 00:00:00 EST 2020 · Neural Regeneration Research

DOI:https://doi.org/10.4103/1673-5374.272572· OSTI ID:1628703

Martinez, Bridget ^[1]; Peplow, Philip V. ^[2]

Los Alamos National Laboratory (LANL), Los Alamos, NM (United States); St. Georges University, True Blue (Grenada); DOE/OSTI
University of Otago, Dunedin (New Zealand). Dept. of Anatomy

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. The disability caused by inflammatory demyelination clinically dominates the early stages of relapsing-remitting MS and is reversible. Once there is considerable loss of axons, MS patients enter a secondary progressive stage. Disease-modifying drugs currently in use for MS suppress the immune system and reduce relapse rates but are not effective in the progressive stage. Various animal models of MS (mostly mouse and rat) have been established and proved useful in studying the disease process and response to therapy. The experimental autoimmune encephalomyelitis animal studies reviewed here showed that a chronic progressive disease can be induced by immunization with appropriate amounts of myelin oligodendrocyte glycoprotein together with mycobacterium tuberculosis and pertussis toxin in Freund’s adjuvant. The clinical manifestations of autoimmune encephalomyelitis disease were prevented or reduced by treatment with certain pharmacological agents given prior to, at, or after peak disease, and the agents had protective effects as shown by inhibiting demyelination and damage to neurons, axons and oligodendrocytes. In the cuprizone-induced toxicity animal studies, the pharmacological agents tested were able to promote remyelination and increase the number of oligodendrocytes when administered therapeutically or prophylactically. A monoclonal IgM antibody protected axons in the spinal cord and preserved motor function in animals inoculated with Theiler’s murine encephalomyelitis virus. In all these studies the pharmacological agents were administered singly. A combination therapy may be more effective, especially using agents that target neuroinflammation and neurodegeneration, as they may exert synergistic actions.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1628703

Journal Information:: Neural Regeneration Research, Journal Name: Neural Regeneration Research Journal Issue: 7 Vol. 15; ISSN 1673-5374

Publisher:: Chinese Association of Rehabilitation Medicine (CARM)Copyright Statement

Country of Publication:: United States

Language:: English

References (76)

Defining interferon ? response status in multiple sclerosis patients Rudick, Richard A.; Lee, Jar-Chi; Simon, Jack Annals of Neurology, Vol. 56, Issue 4 https://doi.org/10.1002/ana.20224	journal	January 2004
Impact of pregabalin treatment on synaptic plasticity and glial reactivity during the course of experimental autoimmune encephalomyelitis Silva, Gleidy A. A.; Pradella, Fernando; Moraes, Adriel Brain and Behavior, Vol. 4, Issue 6 https://doi.org/10.1002/brb3.276	journal	September 2014
Characterization of relapsing-remitting and chronic forms of experimental autoimmune encephalomyelitis in C57BL/6 mice Berard, Jennifer L.; Wolak, Kevin; Fournier, Sylvie Glia https://doi.org/10.1002/glia.20935	journal	January 2009
Restoration of axon conduction and motor deficits by therapeutic treatment with glatiramer acetate Moore, Spencer; Khalaj, Anna J.; Patel, Rhusheet Journal of Neuroscience Research, Vol. 96, Issue 1 https://doi.org/10.1002/jnr.24137	journal	November 2017
Theiler's Murine Encephalomyelitis Virus (TMEV)-Induced Demyelination: A Model for Human Multiple Sclerosis Dal Canto, Mauro C.; Kim, Byung S.; Miller, Stephen D. Methods, Vol. 10, Issue 3 https://doi.org/10.1006/meth.1996.0123	journal	December 1996
Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination Preisner, Anna; Albrecht, Stefanie; Cui, Qiao-Ling Acta Neuropathologica, Vol. 130, Issue 2 https://doi.org/10.1007/s00401-015-1426-z	journal	May 2015
Multimodal Analysis in Acute and Chronic Experimental Autoimmune Encephalomyelitis Giatti, Silvia; Boraso, Mariaserena; Abbiati, Federico Journal of Neuroimmune Pharmacology, Vol. 8, Issue 1 https://doi.org/10.1007/s11481-012-9385-9	journal	June 2012
Neuroprotective Effects of Melatonin on Experimental Allergic Encephalomyelitis Mice Via Anti-Oxidative Stress Activity Long, Ting; Yang, Yuan; Peng, Ling Journal of Molecular Neuroscience, Vol. 64, Issue 2 https://doi.org/10.1007/s12031-017-1022-x	journal	February 2018
Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis Silva, Rodrigo B. M.; Greggio, Samuel; Venturin, Gianina T. Molecular Neurobiology, Vol. 55, Issue 12 https://doi.org/10.1007/s12035-018-1049-1	journal	April 2018
Promoting remyelination for the treatment of multiple sclerosis: opportunities and challenges Zhang, Yueting; Guo, Taylor B.; Lu, Hongtao Neuroscience Bulletin, Vol. 29, Issue 2 https://doi.org/10.1007/s12264-013-1317-z	journal	April 2013
Cuprizone neurotoxicity in the rat: Morphologic observations Love, S. Journal of the Neurological Sciences, Vol. 84, Issue 2-3 https://doi.org/10.1016/0022-510x(88)90127-x	journal	April 1988
Adrenomedullin protects from experimental autoimmune encephalomyelitis at multiple levels Pedreño, Marta; Morell, Maria; Robledo, Gema Brain, Behavior, and Immunity, Vol. 37 https://doi.org/10.1016/j.bbi.2013.11.021	journal	March 2014
IFN-β and multiple sclerosis: From etiology to therapy and back Annibali, V.; Mechelli, R.; Romano, S. Cytokine & Growth Factor Reviews, Vol. 26, Issue 2 https://doi.org/10.1016/j.cytogfr.2014.10.010	journal	April 2015
Animal models of Multiple Sclerosis Procaccini, Claudio; De Rosa, Veronica; Pucino, Valentina European Journal of Pharmacology, Vol. 759 https://doi.org/10.1016/j.ejphar.2015.03.042	journal	July 2015
Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination Sui, Ruo-Xuan; Miao, Qiang; Wang, Jing International Immunopharmacology, Vol. 66 https://doi.org/10.1016/j.intimp.2018.09.041	journal	January 2019
Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing–remitting or chronic EAE Aharoni, Rina; Eilam, Raya; Stock, Ariel Journal of Neuroimmunology, Vol. 225, Issue 1-2 https://doi.org/10.1016/j.jneuroim.2010.04.022	journal	August 2010
The epigenetic drug Trichostatin A ameliorates experimental autoimmune encephalomyelitis via T cell tolerance induction and impaired influx of T cells into the spinal cord Jayaraman, Arathi; Soni, Advait; Prabhakar, Bellur S. Neurobiology of Disease, Vol. 108 https://doi.org/10.1016/j.nbd.2017.07.015	journal	December 2017
Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication Steelman, Andrew J.; Thompson, Jeffrey P.; Li, Jianrong Neuroscience Research, Vol. 72, Issue 1 https://doi.org/10.1016/j.neures.2011.10.002	journal	January 2012
Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis Dutta, Ranjan; Trapp, Bruce D. Progress in Neurobiology, Vol. 93, Issue 1 https://doi.org/10.1016/j.pneurobio.2010.09.005	journal	January 2011
Genetic and epigenetic influence on EAE phenotypes induced with different encephalitogenic peptides Sobel, Raymond A. Journal of Neuroimmunology, Vol. 108, Issue 1-2 https://doi.org/10.1016/s0165-5728(99)00270-2	journal	August 2000
Passive induction of experimental allergic encephalomyelitis Stromnes, Ingunn M.; Goverman, Joan M. Nature Protocols, Vol. 1, Issue 4 https://doi.org/10.1038/nprot.2006.284	journal	November 2006
Achievements and obstacles of remyelinating therapies in multiple sclerosis Stangel, Martin; Kuhlmann, Tanja; Matthews, Paul M. Nature Reviews Neurology, Vol. 13, Issue 12 https://doi.org/10.1038/nrneurol.2017.139	journal	November 2017
Neuronal microRNA regulation in Experimental Autoimmune Encephalomyelitis Juźwik, Camille A.; Drake, Sienna; Lécuyer, Marc-André Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-31542-y	journal	September 2018
Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model Khan, Reas S.; Dine, Kimberly; Bauman, Bailey Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/srep41768	journal	January 2017
Cuprizone Demyelination of the Corpus Callosum in Mice Correlates with Altered Social Interaction and Impaired Bilateral Sensorimotor Coordination Hibbits, Norah; Pannu, Ravinder; Wu, T. John ASN Neuro, Vol. 1, Issue 3 https://doi.org/10.1042/an20090032	journal	May 2009
Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis Aharoni, Rina; Herschkovitz, Avia; Eilam, Raya Proceedings of the National Academy of Sciences, Vol. 105, Issue 32 https://doi.org/10.1073/pnas.0804632105	journal	August 2008
Do pre-clinical multiple sclerosis models allow us to measure neurodegeneration and clinical progression? Hochstrasser, Tanja; Jiangshan, Zhan; Rühling, Sebastian Expert Review of Neurotherapeutics, Vol. 18, Issue 5 https://doi.org/10.1080/14737175.2018.1459190	journal	April 2018
Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research Gold, R. Brain, Vol. 129, Issue 8 https://doi.org/10.1093/brain/awl075	journal	July 2006
Oestrogen receptor β ligand acts on CD11c+ cells to mediate protection in experimental autoimmune encephalomyelitis Kim, Roy Y.; Mangu, Darian; Hoffman, Alexandria S. Brain, Vol. 141, Issue 1 https://doi.org/10.1093/brain/awx315	journal	December 2017
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases Franceschi, C.; Campisi, J. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol. 69, Issue Suppl 1 https://doi.org/10.1093/gerona/glu057	journal	May 2014
Antibody Association with a Novel Model for Primary Progressive Multiple Sclerosis: Induction of Relapsing-Remitting and Progressive Forms of EAE in H2S Mouse Strains Tsunoda, Ikuo; Kuang, Li-Qing; Theil, Diethilde J. Brain Pathology, Vol. 10, Issue 3 https://doi.org/10.1111/j.1750-3639.2000.tb00272.x	journal	April 2006
SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination Taylor, Lorelei C.; Gilmore, Wendy; Matsushima, Glenn K. Brain Pathology, Vol. 19, Issue 3 https://doi.org/10.1111/j.1750-3639.2008.00230.x	journal	July 2009
Theiler's murine encephalomyelitis virus group includes two distinct genetic subgroups that differ pathologically and biologically Lorch, Y.; Friedmann, A.; Lipton, H. L. Journal of Virology, Vol. 40, Issue 2 https://doi.org/10.1128/jvi.40.2.560-567.1981	journal	November 1981
Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat Qiu, Xuemei; Luo, Hui; Liu, Xue Journal of Immunology Research, Vol. 2018 https://doi.org/10.1155/2018/2952471	journal	January 2018
Dihydrotestosterone as a Protective Agent in Chronic Experimental Autoimmune Encephalomyelitis Giatti, Silvia; Rigolio, Roberta; Romano, Simone Neuroendocrinology, Vol. 101, Issue 4 https://doi.org/10.1159/000381064	journal	January 2015
Targets of therapy in progressive MS Lassmann, Hans Multiple Sclerosis Journal, Vol. 23, Issue 12 https://doi.org/10.1177/1352458517729455	journal	October 2017
A monoclonal natural human IgM protects axons in the absence of remyelination Wootla, Bharath; Denic, Aleksandar; Warrington, Arthur E. Journal of Neuroinflammation, Vol. 13, Issue 1 https://doi.org/10.1186/s12974-016-0561-3	journal	April 2016
Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis Gentile, Antonietta; Musella, Alessandra; Bullitta, Silvia Journal of Neuroinflammation, Vol. 13, Issue 1 https://doi.org/10.1186/s12974-016-0686-4	journal	August 2016
Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945 Beckmann, Nicolau; Giorgetti, Elisa; Neuhaus, Anna Acta Neuropathologica Communications, Vol. 6, Issue 1 https://doi.org/10.1186/s40478-018-0510-8	journal	February 2018
Neuroprotective therapies for multiple sclerosis and other demyelinating diseases Villoslada, Pablo Multiple Sclerosis and Demyelinating Disorders, Vol. 1, Issue 1 https://doi.org/10.1186/s40893-016-0004-0	journal	April 2016
Neuroprotective Effect of Combination Therapy of Glatiramer Acetate and Epigallocatechin-3-Gallate in Neuroinflammation Herges, Katja; Millward, Jason M.; Hentschel, Nicole PLoS ONE, Vol. 6, Issue 10 https://doi.org/10.1371/journal.pone.0025456	journal	October 2011
Treatment of Chronic Experimental Autoimmune Encephalomyelitis with Epigallocatechin-3-Gallate and Glatiramer Acetate Alters Expression of Heme-Oxygenase-1 Janssen, Antonia; Fiebiger, Sebastian; Bros, Helena PLOS ONE, Vol. 10, Issue 6 https://doi.org/10.1371/journal.pone.0130251	journal	June 2015
Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis Ghaffarpasand, Fariborz; Torabi, Saeed; Rasti, Ali Neuropsychiatric Disease and Treatment, Vol. Volume 15 https://doi.org/10.2147/ndt.s186865	journal	December 2018
Remyelination in multiple sclerosis: what do we know and where are we going? Williams, Anna Neurodegenerative Disease Management, Vol. 5, Issue 1 https://doi.org/10.2217/nmt.14.40	journal	February 2015
Cortical Demyelination Is Prominent in the Murine Cuprizone Model and Is Strain-Dependent Skripuletz, Thomas; Lindner, Maren; Kotsiari, Alexandra The American Journal of Pathology, Vol. 172, Issue 4 https://doi.org/10.2353/ajpath.2008.070850	journal	April 2008
Cutting Edge: CD4⁺CD25⁺ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis Kohm, Adam P.; Carpentier, Pamela A.; Anger, Holly A. The Journal of Immunology, Vol. 169, Issue 9 https://doi.org/10.4049/jimmunol.169.9.4712	journal	November 2002
Restoration of axon conduction and motor deficits by therapeutic treatment with glatiramer acetate Moore, Spencer; Khalaj, Anna J.; Patel, Rhusheet Journal of Neuroscience Research, Vol. 92, Issue 12 https://doi.org/10.1002/jnr.23440	journal	July 2014
Immunology of theiler’s murine encephalomyelitis virus infection Oleszak, Emilia L.; Kuzmak, Jacek; Good, Robert A. Immunologic Research, Vol. 14, Issue 1 https://doi.org/10.1007/BF02918495	journal	March 1995
Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation Mossakowski, Agata A.; Pohlan, Julian; Bremer, Daniel Acta Neuropathologica, Vol. 130, Issue 6 https://doi.org/10.1007/s00401-015-1497-x	journal	October 2015
Comparative Neuroregenerative Effects of C-Phycocyanin and IFN-Beta in a Model of Multiple Sclerosis in Mice Pentón-Rol, Giselle; Lagumersindez-Denis, Nielsen; Muzio, Luca Journal of Neuroimmune Pharmacology, Vol. 11, Issue 1 https://doi.org/10.1007/s11481-015-9642-9	journal	November 2015
Cuprizone neurotoxicity in the rat: Morphologic observations Love, S. Journal of the Neurological Sciences, Vol. 84, Issue 2-3 https://doi.org/10.1016/0022-510X(88)90127-X	journal	April 1988
Genetic and epigenetic influence on EAE phenotypes induced with different encephalitogenic peptides Sobel, Raymond A. Journal of Neuroimmunology, Vol. 108, Issue 1-2 https://doi.org/10.1016/S0165-5728(99)00270-2	journal	August 2000
Epicutaneous Immunization with Autoantigenic Peptides Induces T Suppressor Cells that Prevent Experimental Allergic Encephalomyelitis Bynoe, Margaret S.; Evans, J. Tori; Viret, Christophe Immunity, Vol. 19, Issue 3 https://doi.org/10.1016/S1074-7613(03)00239-5	journal	September 2003
Neuroprotective effects of a polyphenolic white grape juice extract in a mouse model of experimental autoimmune encephalomyelitis Giacoppo, Sabrina; Galuppo, Maria; Lombardo, Giovanni Enrico Fitoterapia, Vol. 103 https://doi.org/10.1016/j.fitote.2015.04.003	journal	June 2015
Theiler's murine encephalomyelitis virus infection of SJL/J and C57BL/6J mice: Models for multiple sclerosis and epilepsy DePaula-Silva, Ana Beatriz; Hanak, Tyler J.; Libbey, Jane E. Journal of Neuroimmunology, Vol. 308 https://doi.org/10.1016/j.jneuroim.2017.02.012	journal	July 2017
Chronic caffeine treatment protects against experimental autoimmune encephalomyelitis in mice: Therapeutic window and receptor subtype mechanism Wang, Tan; Xi, Na-na; Chen, Yu Neuropharmacology, Vol. 86 https://doi.org/10.1016/j.neuropharm.2014.06.029	journal	November 2014
Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation Elbaz, Eman M.; Senousy, Mahmoud A.; El-Tanbouly, Dalia M. Toxicology and Applied Pharmacology, Vol. 352 https://doi.org/10.1016/j.taap.2018.05.035	journal	August 2018
Active induction of experimental allergic encephalomyelitis Stromnes, Ingunn M.; Goverman, Joan M. Nature Protocols, Vol. 1, Issue 4 https://doi.org/10.1038/nprot.2006.285	journal	November 2006
The origin and application of experimental autoimmune encephalomyelitis Baxter, Alan G. Nature Reviews Immunology, Vol. 7, Issue 11 https://doi.org/10.1038/nri2190	journal	November 2007
Cuprizone Demyelination of the Corpus Callosum in Mice Correlates with Altered Social Interaction and Impaired Bilateral Sensorimotor Coordination Hibbits, Norah; Pannu, Ravinder; Wu, T. John ASN Neuro, Vol. 1, Issue 3 https://doi.org/10.1042/AN20090032	journal	May 2009
Multiple functional therapeutic effects of the estrogen receptor β agonist indazole-Cl in a mouse model of multiple sclerosis Moore, Spencer M.; Khalaj, Anna J.; Kumar, Shalini Proceedings of the National Academy of Sciences, Vol. 111, Issue 50 https://doi.org/10.1073/pnas.1411294111	journal	December 2014
The contribution of demyelination to axonal loss in multiple sclerosis DeLuca, G. C. Brain, Vol. 129, Issue 6 https://doi.org/10.1093/brain/awl074	journal	April 2006
Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis Encinas, Jeffrey A.; Lees, Marjorie B.; Sobel, Raymond A. International Immunology, Vol. 13, Issue 3 https://doi.org/10.1093/intimm/13.3.257	journal	March 2001
N-Methyl-d-Aspartate Receptor Blockade Is Neuroprotective in Experimental Autoimmune Optic Neuritis Sühs, Kurt-Wolfram; Fairless, Richard; Williams, Sarah K. Journal of Neuropathology & Experimental Neurology, Vol. 73, Issue 6 https://doi.org/10.1097/NEN.0000000000000073	journal	June 2014
Lanthionine ketimine ester provides benefit in a mouse model of multiple sclerosis Dupree, Jeffrey L.; Polak, Paul E.; Hensley, Kenneth Journal of Neurochemistry, Vol. 134, Issue 2 https://doi.org/10.1111/jnc.13114	journal	April 2015
Theiler's Virus Infection: a Model for Multiple Sclerosis Oleszak, Emilia L.; Chang, J. Robert; Friedman, Herman Clinical Microbiology Reviews, Vol. 17, Issue 1 https://doi.org/10.1128/CMR.17.1.174-207.2004	journal	January 2004
Theiler's murine encephalomyelitis virus group includes two distinct genetic subgroups that differ pathologically and biologically Lorch, Y.; Friedmann, A.; Lipton, H. L. Journal of Virology, Vol. 40, Issue 2 https://doi.org/10.1128/JVI.40.2.560-567.1981	journal	November 1981
Neurodegeneration in Multiple Sclerosis: Relationship to Neurological Disability Trapp, Bruce D.; Ransohoff, Richard M.; Fisher, Elizabeth The Neuroscientist, Vol. 5, Issue 1 https://doi.org/10.1177/107385849900500107	journal	January 1999
Animal models of multiple sclerosis: From rodents to zebrafish Burrows, David John; McGown, Alexander; Jain, Saurabh A. Multiple Sclerosis Journal, Vol. 25, Issue 3 https://doi.org/10.1177/1352458518805246	journal	October 2018
Featured Article: Serum [Met⁵]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone Ludwig, Michael D.; Zagon, Ian S.; McLaughlin, Patricia J. Experimental Biology and Medicine, Vol. 242, Issue 15 https://doi.org/10.1177/1535370217724791	journal	August 2017
The prevalence of MS in the United States Wallin, Mitchell T.; Culpepper, William J.; Campbell, Jonathan D. Neurology, Vol. 92, Issue 10 https://doi.org/10.1212/WNL.0000000000007035	journal	February 2019
Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis Ghaffarpasand, Fariborz; Torabi, Saeed; Rasti, Ali Neuropsychiatric Disease and Treatment, Vol. Volume 15 https://doi.org/10.2147/NDT.S186865	journal	December 2018
In Vitro and In Vivo Models of Multiple Sclerosis J. van der Star, Baukje; Y. S. Vogel, Daphne; Kipp, Markus CNS & Neurological Disorders - Drug Targets, Vol. 11, Issue 5 https://doi.org/10.2174/187152712801661284	journal	June 2012
Source of Chronic Inflammation in Aging Sanada, Fumihiro; Taniyama, Yoshiaki; Muratsu, Jun Frontiers in Cardiovascular Medicine, Vol. 5 https://doi.org/10.3389/fcvm.2018.00012	journal	February 2018
Tuftsin Combines With Remyelinating Therapy and Improves Outcomes in Models of CNS Demyelinating Disease Thompson, Kaitlyn K.; Nissen, Jillian C.; Pretory, Amanda Frontiers in Immunology, Vol. 9 https://doi.org/10.3389/fimmu.2018.02784	journal	November 2018
Variation in experimental autoimmune encephalomyelitis scores in a mouse model of multiple sclerosis Takeuchi, Chisen; Yamagata, Kanato; Takemiya, Takako World Journal of Neurology, Vol. 3, Issue 3 https://doi.org/10.5316/wjn.v3.i3.56	journal	January 2013

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60 APPLIED LIFE SCIENCES
Theiler’s murine encephalomyelitis virus
animal models
autoimmune encephalomyelitis disease
cell biology
cuprizone-induced toxicity
multiple sclerosis
neurodegeneration
neuroinflammation
neurology
neuroprotection
neurosciences
pharmacological agents
progressive disease

Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014–2019

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References (76)

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