Delineating Chromosomal Breakpoints in Radiation-Induced Papillary Thyroid Cancer

Weier, Heinz-Ulrich G.; Ito, Yuko; Kwan, Johnson; Smida, Jan; Weier, Jingly F.; Hieber, Ludwig; Lu, Chun-Mei; Lehmann, Lars; Wang, Mei; Kassabian, Haig J.; Zeng, Hui; O’Brien, Benjamin

doi:10.3390/genes2030397

Delineating Chromosomal Breakpoints in Radiation-Induced Papillary Thyroid Cancer

Journal Article · Tue Jun 28 00:00:00 EDT 2011 · Genes

DOI:https://doi.org/10.3390/genes2030397· OSTI ID:1628322

Weier, Heinz-Ulrich G. ^[1]; Ito, Yuko ^[2]; Kwan, Johnson ^[3]; Smida, Jan ^[4]; Weier, Jingly F. ^[5]; Hieber, Ludwig ^[6]; Lu, Chun-Mei ^[7]; Lehmann, Lars ^[8]; Wang, Mei ^[9]; Kassabian, Haig J. ^[3]; Zeng, Hui ^[3]; O’Brien, Benjamin ^[10]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division; DOE/OSTI
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division; National Inst. of Science and Technology Policy (NISTEP), Tokyo (Japan). Ministry of Education, Culture, Sports, Science and Technology
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division
German Research Center for Environmental Health, Neuherberg (Germany). Clinical Cooperation Group Osteosarcoma
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division; Univ. of California, San Francisco, CA (United States). Clinical Labs--Cytogenetics
German Research Center for Environmental Health, Neuherberg (Germany). Clinical Cooperation Group Osteosarcoma
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division; National Chin-Yi Univ. of Technology, Taiping City (Taiwan). Dept. of Chemical and Materials Engineering
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division; German Research Center for Environmental Health, Neuherberg (Germany). Clinical Cooperation Group Osteosarcoma; Roche Diagnostics GmbH, Penzberg (Germany)
City of Hope, Duarte, CA (United States). Dept. of Diabetes
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division; Barts andThe London School of Medicine (United Kingdom). Translational Medicine and Therapeutics. Williiam Harvey Research Inst.; German Heart Institute Berlin (Germany). Dept. of Anesthesiology

Recurrent translocations are well known hallmarks of many human solid tumors and hematological disorders, where patient- and breakpoint-specific information may facilitate prognostication and individualized therapy. In thyroid carcinomas, the proto-oncogenes RET and NTRK1 are often found to be activated through chromosomal rearrangements. However, many sporadic tumors and papillary thyroid carcinomas (PTCs) arising in patients with a history of exposure to elevated levels of ionizing irradiation do not carry these known abnormalities. We developed a rapid scheme to screen tumor cell metaphase spreads and identify candidate genes of tumorigenesis and neoplastic progression for subsequent functional studies. Using a series of overnight fluorescence in situ hybridization (FISH) experiments with pools comprised of bacterial artificial chromosome (BAC) clones, it now becomes possible to rapidly refine breakpoint maps and, within one week, progress from the low resolution Spectral Karyotyping (SKY) maps or Giemsa-banding (G-banding) karyotypes to fully integrated, high resolution physical maps including a list of candiate genes in the critical regions.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1628322

Journal Information:: Genes, Journal Name: Genes Journal Issue: 3 Vol. 2; ISSN 2073-4425; ISSN GENEG9

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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