Flux, Impact, and Fate of Halogenated Xenobiotic Compounds in the Gut

Atashgahi, Siavash; Shetty, Sudarshan A.; Smidt, Hauke; de Vos, Willem M.

doi:10.3389/fphys.2018.00888

Flux, Impact, and Fate of Halogenated Xenobiotic Compounds in the Gut

Journal Article · Tue Jul 10 00:00:00 EDT 2018 · Frontiers in Physiology

DOI:https://doi.org/10.3389/fphys.2018.00888· OSTI ID:1628215

Atashgahi, Siavash ^[1]; Shetty, Sudarshan A. ^[2]; Smidt, Hauke ^[2]; de Vos, Willem M. ^[3]

Wageningen Univ. (Netherlands); DOE/OSTI
Wageningen Univ. (Netherlands)
Wageningen Univ. (Netherlands); Univ. of Helsinki (Finland)

Humans and their associated microbiomes are exposed to numerous xenobiotics through drugs, dietary components, personal care products as well as environmental chemicals. Most of the reciprocal interactions between the microbiota and xenobiotics, such as halogenated compounds, occur within the human gut harboring diverse and dense microbial communities. Here, we provide an overview of the flux of halogenated compounds in the environment, and diverse exposure routes of human microbiota to these compounds. Subsequently, we review the impact of halogenated compounds in perturbing the structure and function of gut microbiota and host cells. In turn, cultivation-dependent and metagenomic surveys of dehalogenating genes revealed the potential of the gut microbiota to chemically alter halogenated xenobiotics and impact their fate. Finally, we provide an outlook for future research to draw attention and attract interest to study the bidirectional impact of halogenated and other xenobiotic compounds and the gut microbiota.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: Netherlands Organization for Scientific Research (NWO); Soehngen Institute of Anaerobic Microbiology (SIAM) Gravitation; USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1628215

Journal Information:: Frontiers in Physiology, Journal Name: Frontiers in Physiology Vol. 9; ISSN 1664-042X

Publisher:: Frontiers Media S.A.Copyright Statement

Country of Publication:: United States

Language:: English

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