Potential Contribution of Aromatase Inhibition to the Effects of Nicotine and Related Compounds on the Brain

Biegon, Anat; Alia-Klein, Nelly; Fowler, Joanna S.

doi:10.3389/fphar.2012.00185

Potential Contribution of Aromatase Inhibition to the Effects of Nicotine and Related Compounds on the Brain

Journal Article · Mon Nov 05 23:00:00 EST 2012 · Frontiers in Pharmacology

DOI:https://doi.org/10.3389/fphar.2012.00185· OSTI ID:1628211

Biegon, Anat ^[1]; Alia-Klein, Nelly ^[2]; Fowler, Joanna S. ^[2]

Brookhaven National Lab. (BNL), Upton, NY (United States); DOE/OSTI
Brookhaven National Lab. (BNL), Upton, NY (United States)

Cigarette smoking continues to be a major public health problem, and while smoking rates in men have shown some decrease over the last few decades, smoking rates among girls and young women are increasing. Practically all of the important aspects of cigarette smoking and many effects of nicotine are sexually dimorphic (reviewed by Pogun and Yararbas, 2009). Women become addicted more easily than men, while finding it harder to quit. Nicotine replacement appears to be less effective in women. This may be linked to the observation that women are more sensitive than men to non-nicotine cues or ingredients in cigarettes. The reasons for these sex differences are mostly unknown. Several lines of evidence suggest that many of the reported sex differences related to cigarette smoking may stem from the inhibitory effects of nicotine and other tobacco alkaloids on estrogen synthesis via the enzyme aromatase (cyp19a gene product). Aromatase is the last enzyme in estrogen biosynthesis, catalyzing the conversion of androgens to estrogens.This review provides a summary of experimental evidence supporting brain aromatase as a potential mediator and/or modulator of nicotine actions in the brain, contributing to sex differences in smoking behavior. Additional research on the interaction between tobacco smoke, nicotine, and aromatase may help devise new, sex specific methods for prevention and treatment of smoking addiction.

View Accepted Manuscript (DOE)

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

OSTI ID:: 1628211

Journal Information:: Frontiers in Pharmacology, Journal Name: Frontiers in Pharmacology Vol. 3; ISSN 1663-9812

Publisher:: Frontiers Research FoundationCopyright Statement

Country of Publication:: United States

Language:: English

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