p53 binding to human genome: crowd control navigation in chromatin context

Botcheva, Krassimira

doi:10.3389/fgene.2014.00447

p53 binding to human genome: crowd control navigation in chromatin context

Journal Article · Sun Dec 21 23:00:00 EST 2014 · Frontiers in Genetics

DOI:https://doi.org/10.3389/fgene.2014.00447· OSTI ID:1628036

Botcheva, Krassimira ^[1]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division. Cell and Molecular Biology Dept.; DOE/OSTI

p53 is the most studied human protein because of its role in maintaining genomic stability. Binding to genomic targets is essential for transcription-dependent p53 tumor suppression, but how p53 selects targets remains unclear. Here, the impact of chromatin context on p53 genome-wide binding and targets selection is discussed. It is proposed that p53 genomic binding serves not only to regulate transcription, but to sense epigenomic changes threatening the genomic integrity. The problem of p53 navigating the human genome is discussed with respect to the degenerate p53 binding motif. This discussion relates to the fundamental problem of DNA binding factors navigating large genomes in search for cognate binding sites.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1628036

Journal Information:: Frontiers in Genetics, Journal Name: Frontiers in Genetics Vol. 5; ISSN 1664-8021

Publisher:: FrontiersCopyright Statement

Country of Publication:: United States

Language:: English

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