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Race/Ethnicity Disparities in Dysglycemia Among U.S. Women of Childbearing Age Found Mainly in the Nonoverweight/Nonobese

Journal Article · · Diabetes Care
DOI:https://doi.org/10.2337/dc12-2312· OSTI ID:1628018
 [1];  [2];  [3];  [2];  [4];  [5]
  1. Centers for Disease Control and Prevention (CDC), Atlanta, GA (United States); Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States); Emory University, Atlanta, GA (United States); DOE/OSTI
  2. Centers for Disease Control and Prevention (CDC), Atlanta, GA (United States)
  3. Emory University, Atlanta, GA (United States)
  4. D-Tree International, Weston, MA (United States)
  5. Univ. of Mississippi, Jackson, MS (United States)
+ Show Author Affiliations
To describe the burden of dysglycemia—abnormal glucose metabolism indicative of diabetes or high risk for diabetes—among U.S. women of childbearing age, focusing on differences by race/ethnicity. Using U.S. National Health and Nutrition Examination Survey data (1999–2008), we calculated the burden of dysglycemia (i.e., prediabetes or diabetes from measures of fasting glucose, A1C, and self-report) in nonpregnant women of childbearing age (15–49 years) by race/ethnicity status. We estimated prevalence risk ratios (PRRs) for dysglycemia in subpopulations stratified by BMI (measured as kilograms divided by the square of height in meters), using predicted marginal estimates and adjusting for age, waist circumference, C-reactive protein, and socioeconomic factors. Based on data from 7,162 nonpregnant women, representing >59,000,000 women nationwide, 19% (95% CI 17.2–20.9) had some level of dysglycemia, with higher crude prevalence among non-Hispanic blacks and Mexican Americans vs. non-Hispanic whites (26.3% [95% CI 22.3–30.8] and 23.8% [19.5–28.7] vs. 16.8% [14.4–19.6], respectively). In women with BMI <25 kg/m2, dysglycemia prevalence was roughly twice as high in both non-Hispanic blacks and Mexican Americans vs. non-Hispanic whites. This relative increase persisted in adjusted models (PRRadj 1.86 [1.16–2.98] and 2.23 [1.38–3.60] for non-Hispanic blacks and Mexican Americans, respectively). For women with BMI 25–29.99 kg/m2, only non-Hispanic blacks showed increased prevalence vs. non-Hispanic whites (PRRadj 1.55 [1.03–2.34] and 1.28 [0.73–2.26] for non-Hispanic blacks and Mexican Americans, respectively). In women with BMI >30 kg/m2, there was no significant increase in prevalence of dysglycemia by race/ethnicity category. Our findings show that dysglycemia affects a significant portion of U.S. women of childbearing age and that disparities by race/ethnicity are most prominent in the nonoverweight/nonobese.
Research Organization:
Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
Sponsoring Organization:
Centers for Disease Control and Prevention (CDC); USDOE Office of Science (SC), Biological and Environmental Research (BER)
Grant/Contract Number:
SC0014664
OSTI ID:
1628018
Journal Information:
Diabetes Care, Journal Name: Diabetes Care Journal Issue: 10 Vol. 36; ISSN 0149-5992
Publisher:
American Diabetes AssociationCopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (3)

High-risk glycated hemoglobin trajectories established by mid-20s: findings from a birth cohort study journal August 2016
The obesity epidemic and rising diabetes incidence in a low-income racially diverse southern US cohort journal January 2018
Contraceptive Use Among Women with Prediabetes and Diabetes in a US National Sample journal December 2018

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