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Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD

Journal Article · · Chest
 [1];  [2];  [2];  [2];  [2];  [2];  [2];  [2];  [2];  [2];  [2];  [2]
  1. Univ. of Leicester (United Kingdom). Glenfield Hospital. Clinical Sciences Wing. Inst. for Lung Health; DOE/OSTI
  2. Univ. of Leicester (United Kingdom). Glenfield Hospital. Clinical Sciences Wing. Inst. for Lung Health
Asthma and COPD are characterized by airway dysfunction and infl ammation. Neutrophilic airway infl ammation is a common feature of COPD and is recognized in asthma, particularly in severe disease. The T helper (Th) 17 cytokines IL-17A and IL-17F have been implicated in the development of neutrophilic airway infl ammation, but their expression in asthma and COPD is uncertain. Methods: We assessed IL-17A and IL-17F expression in the bronchial submucosa from 30 subjects with asthma, 10 ex-smokers with mild to moderate COPD, and 27 nonsmoking and 14 smoking control subjects. Sputum IL-17 concentration was measured in 165 subjects with asthma and 27 with COPD. Results: The median (interquartile range) IL-17A cells/mm2 submucosa was increased in mild to moderate asthma (2.1 [2.4]) compared with healthy control subjects (0.4 [2.8]) but not in severe asthma (P = .04). In COPD, IL-17A+ cells/mm2 submucosa were increased (0.5 [3.7]) compared with nonsmoking control subjects (0 [0]) but not compared with smoking control subjects (P = .046). IL-17F+ cells/mm2 submucosa were increased in severe asthma (2.7 [3.6]) and mild to moderate asthma (1.6 [1.0]) compared with healthy controls subjects (0.7 [1.4]) (P = .001) but was not increased in subjects with COPD. IL-17A and IL-17F were not associated with increased neutrophilic inflammation, but IL-17F was correlated with the submucosal eosinophil count (rs = 0.5, P = .005). The sputum IL-17 concentration in COPD was increased compared with asthma (2 [0–7] pg/mL vs 0 [0–2] pg/mL, P < .0001) and was correlated with post-bronchodilator FEV1% predicted (r = -0.5, P = .008) and FEV1/FVC (r = -0.4, P = .04). Our findings support a potential role for the Th17 cytokines IL-17A and IL-17F in asthma and COPD, but do not demonstrate a relationship with neutrophilic inflammation
Research Organization:
Univ. of Leicester (United Kingdom)
Sponsoring Organization:
Asthma UK; MedImmune Ltd.; USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
OSTI ID:
1627925
Journal Information:
Chest, Journal Name: Chest Journal Issue: 5 Vol. 138; ISSN 0012-3692
Publisher:
American College of Chest Physicians, ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

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