Asthma and COPD are characterized by airway dysfunction and infl ammation. Neutrophilic airway infl ammation is a common feature of COPD and is recognized in asthma, particularly in severe disease. The T helper (Th) 17 cytokines IL-17A and IL-17F have been implicated in the development of neutrophilic airway infl ammation, but their expression in asthma and COPD is uncertain. Methods: We assessed IL-17A and IL-17F expression in the bronchial submucosa from 30 subjects with asthma, 10 ex-smokers with mild to moderate COPD, and 27 nonsmoking and 14 smoking control subjects. Sputum IL-17 concentration was measured in 165 subjects with asthma and 27 with COPD. Results: The median (interquartile range) IL-17A cells/mm2 submucosa was increased in mild to moderate asthma (2.1 [2.4]) compared with healthy control subjects (0.4 [2.8]) but not in severe asthma (P = .04). In COPD, IL-17A+ cells/mm2 submucosa were increased (0.5 [3.7]) compared with nonsmoking control subjects (0 [0]) but not compared with smoking control subjects (P = .046). IL-17F+ cells/mm2 submucosa were increased in severe asthma (2.7 [3.6]) and mild to moderate asthma (1.6 [1.0]) compared with healthy controls subjects (0.7 [1.4]) (P = .001) but was not increased in subjects with COPD. IL-17A and IL-17F were not associated with increased neutrophilic inflammation, but IL-17F was correlated with the submucosal eosinophil count (rs = 0.5, P = .005). The sputum IL-17 concentration in COPD was increased compared with asthma (2 [0–7] pg/mL vs 0 [0–2] pg/mL, P < .0001) and was correlated with post-bronchodilator FEV1% predicted (r = -0.5, P = .008) and FEV1/FVC (r = -0.4, P = .04). Our findings support a potential role for the Th17 cytokines IL-17A and IL-17F in asthma and COPD, but do not demonstrate a relationship with neutrophilic inflammation
Doe, Camille, et al. "Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD." Chest, vol. 138, no. 5, Nov. 2010. https://doi.org/10.1378/chest.09-3058
Doe, Camille, Bafadhel, Mona, Siddiqui, Salman, Desai, Dhananjay, Mistry, Vijay, Rugman, Paul, McCormick, Margaret, Woods, Joanne, May, Richard, Sleeman, Matthew A., Anderson, Ian K., & Brightling, Christopher E. (2010). Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD. Chest, 138(5). https://doi.org/10.1378/chest.09-3058
Doe, Camille, Bafadhel, Mona, Siddiqui, Salman, et al., "Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD," Chest 138, no. 5 (2010), https://doi.org/10.1378/chest.09-3058
@article{osti_1627925,
author = {Doe, Camille and Bafadhel, Mona and Siddiqui, Salman and Desai, Dhananjay and Mistry, Vijay and Rugman, Paul and McCormick, Margaret and Woods, Joanne and May, Richard and Sleeman, Matthew A. and others},
title = {Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD},
annote = {Asthma and COPD are characterized by airway dysfunction and infl ammation. Neutrophilic airway infl ammation is a common feature of COPD and is recognized in asthma, particularly in severe disease. The T helper (Th) 17 cytokines IL-17A and IL-17F have been implicated in the development of neutrophilic airway infl ammation, but their expression in asthma and COPD is uncertain. Methods: We assessed IL-17A and IL-17F expression in the bronchial submucosa from 30 subjects with asthma, 10 ex-smokers with mild to moderate COPD, and 27 nonsmoking and 14 smoking control subjects. Sputum IL-17 concentration was measured in 165 subjects with asthma and 27 with COPD. Results: The median (interquartile range) IL-17A cells/mm2 submucosa was increased in mild to moderate asthma (2.1 [2.4]) compared with healthy control subjects (0.4 [2.8]) but not in severe asthma (P = .04). In COPD, IL-17A+ cells/mm2 submucosa were increased (0.5 [3.7]) compared with nonsmoking control subjects (0 [0]) but not compared with smoking control subjects (P = .046). IL-17F+ cells/mm2 submucosa were increased in severe asthma (2.7 [3.6]) and mild to moderate asthma (1.6 [1.0]) compared with healthy controls subjects (0.7 [1.4]) (P = .001) but was not increased in subjects with COPD. IL-17A and IL-17F were not associated with increased neutrophilic inflammation, but IL-17F was correlated with the submucosal eosinophil count (rs = 0.5, P = .005). The sputum IL-17 concentration in COPD was increased compared with asthma (2 [0–7] pg/mL vs 0 [0–2] pg/mL, P 1% predicted (r = -0.5, P = .008) and FEV1/FVC (r = -0.4, P = .04). Our findings support a potential role for the Th17 cytokines IL-17A and IL-17F in asthma and COPD, but do not demonstrate a relationship with neutrophilic inflammation},
doi = {10.1378/chest.09-3058},
url = {https://www.osti.gov/biblio/1627925},
journal = {Chest},
issn = {ISSN 0012-3692},
number = {5},
volume = {138},
place = {United States},
publisher = {American College of Chest Physicians, Elsevier},
year = {2010},
month = {11}}