Gini Coefficient: A New Way To Express Selectivity of Kinase Inhibitors against a Family of Kinases †
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November 2007 |
Refinement of Macromolecular Structures by the Maximum-Likelihood Method
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May 1997 |
Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy
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January 2013 |
Targeting Syk as a treatment for allergic and autoimmune disorders
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July 2004 |
Comprehensive analysis of kinase inhibitor selectivity
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October 2011 |
B cells move to centre stage: novel opportunities for autoimmune disease treatment
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July 2006 |
Thrombopoietin: a pan-hematopoietic cytokine
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February 2002 |
R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation
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August 2006 |
Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling.
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December 1995 |
The immunomodulatory adapter proteins DAP12 and Fc receptor -chain (FcR ) regulate development of functional osteoclasts through the Syk tyrosine kinase
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April 2004 |
Deletion of Syk in Neutrophils Prevents Immune Complex Arthritis
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September 2011 |
An efficient rapid system for profiling the cellular activities of molecular libraries
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February 2006 |
Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis
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January 2010 |
The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils
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July 1998 |
Establishment and Characterization of a Novel Human Rheumatoid Fibroblast-Like Synoviocyte Line, MH7A, Immortalized with SV40 T Antigen
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December 1998 |
Establishing optimal lymphocyte gates for immunophenotyping by flow cytometry
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January 1990 |
The Syk kinase as a therapeutic target in leukemia and lymphoma
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March 2011 |
Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis
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August 2012 |
Specific Inhibition of Spleen Tyrosine Kinase Suppresses Leukocyte Immune Function and Inflammation in Animal Models of Rheumatoid Arthritis
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October 2011 |
Gö6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells: Gö6976 is a JAK2 and FLT3 Inhibitor
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September 2006 |
Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
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January 2010 |
Highly Miniaturized Formats for In Vitro Drug Metabolism Assays Using Vivid® Fluorescent Substrates and Recombinant Human Cytochrome P450 Enzymes
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February 2005 |
Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050
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April 2010 |
Discovery and Development of Spleen Tyrosine Kinase (SYK) Inhibitors
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February 2012 |
Differential Expression and Molecular Associations of Syk in Systemic Lupus Erythematosus T Cells
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November 2008 |
Janus Kinases: An Ideal Target for the Treatment of Autoimmune Diseases
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December 2013 |
Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies: Pharmacokinetics of fostamatinib in three phase I studies
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June 2013 |
I G G F C R ECEPTORS
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April 2001 |
Involvement of Fcγ receptor IIIA genotypes in susceptibility to rheumatoid arthritis
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April 2000 |
The arthritis severity locus Cia5a regulates the expression of inflammatory mediators including Syk pathway genes and proteases in pristane-induced arthritis
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January 2012 |
The contribution of VEGF signalling to fostamatinib-induced blood pressure elevation: Fostamatinib-induced BP elevation
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April 2014 |
Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor
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September 2007 |
Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk
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April 2009 |
A Novel Spleen Tyrosine Kinase Inhibitor Blocks c-Jun N-Terminal Kinase-Mediated Gene Expression in Synoviocytes
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February 2006 |
Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling
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August 2013 |
Syk tyrosine kinase required for mouse viability and B-cell development
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November 1995 |
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
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April 2010 |
Immunotoxicity assessment for the novel Spleen tyrosine kinase inhibitor R406
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June 2007 |
Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives
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August 2005 |
Safety profile of protein kinase inhibitors in rheumatoid arthritis: systematic review and meta-analysis
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April 2013 |
Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B
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January 2006 |
Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice
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April 2000 |
Multiparametric scaling of diffraction intensities
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April 2003 |
Interleukin-3 Activates Syk in a Human Myeloblastic Leukemia Cell Line, AML193
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November 1997 |
Tumour necrosis factor-alpha potentiates CR3-induced respiratory burst by activating p38 MAP kinase in human neutrophils
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August 2001 |
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production
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October 2005 |
Inhibition of spleen tyrosine kinase in the treatment of rheumatoid arthritis
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July 2013 |
Evolving concepts of rheumatoid arthritis
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May 2003 |
Genetic deficiency of Syk protects mice from autoantibody-induced arthritis
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January 2010 |
Syk kinase as a treatment target for therapy in autoimmune diseases
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September 2007 |
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcεRI or FcγRI
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August 2003 |
Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice
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April 2000 |
Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12)
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February 2001 |
The Serological Diagnosis of Rheumatoid Arthritis
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March 2009 |