The Role of inab in Axon Morphology of an Identified Zebrafish Motoneuron

Van Ryswyk, Liesl; Simonson, Levi; Eisen, Judith S.

doi:10.1371/journal.pone.0088631

**The Role of inab in Axon Morphology of an Identified Zebrafish Motoneuron**

Journal Article · Wed Feb 12 04:00:00 EST 2014 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0088631· OSTI ID:1627679

Van Ryswyk, Liesl ^[1]; Simonson, Levi ^[2]; Eisen, Judith S. ^[2]

University of Oregon, Eugene, OR (United States); DOE/OSTI
University of Oregon, Eugene, OR (United States)

The ability of an animal to move and to interact with its environment requires that motoneurons correctly innervate specific muscles. Although many genes that regulate motoneuron development have been identified, our understanding of motor axon branching remains incomplete. We used transcriptional expression profiling to identify potential candidate genes involved in development of zebrafish identified motoneurons. Here we focus on inab, an intermediate filament encoding gene dynamically expressed in a subset of motoneurons as well as in an identified interneuron. We show that inab is necessary for proper axon morphology of a specific motoneuron subtype.

Research Organization:: University of Oregon, Eugene, OR (United States)

Sponsoring Organization:: National Institutes of Health (NIH)

OSTI ID:: 1627679

Journal Information:: PLoS ONE, Journal Name: PLoS ONE Journal Issue: 2 Vol. 9; ISSN 1932-6203

Publisher:: Public Library of Science

Country of Publication:: United States

Language:: English

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Distribution patterns of the zebrafish neuronal intermediate filaments inaa and inab Liao, Meng‐Lin; Peng, Wei‐Hau; Kan, Daphne Journal of Neuroscience Research, Vol. 97, Issue 2 https://doi.org/10.1002/jnr.24347	journal	October 2018

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
RNA hybridization
axons
gene expression
intermediate filaments
interneurons
microarrays
spinal cord
zebrafish