Dopamine Transporters in Striatum Correlate with Deactivation in the Default Mode Network during Visuospatial Attention

Tomasi, Dardo; Volkow, Nora D.; Wang, Ruiliang; Telang, Frank; Wang, Gene-Jack; Chang, Linda; Ernst, Thomas; Fowler, Joanna S.

doi:10.1371/journal.pone.0006102

Title: Dopamine Transporters in Striatum Correlate with Deactivation in the Default Mode Network during Visuospatial Attention

Journal Article · Tue Jun 30 00:00:00 EDT 2009 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0006102· OSTI ID:1627378

Tomasi, Dardo ^[1]; Volkow, Nora D. ^[1]; Wang, Ruiliang ^[2]; Telang, Frank ^[1]; Wang, Gene-Jack ^[1]; Chang, Linda ^[3]; Ernst, Thomas ^[3]; Fowler, Joanna S. ^[4]

National Institutes of Health (NIH), Bethesda, MD (United States)
Brookhaven National Laboratory (BNL), Upton, NY (United States). Medical Dept.
University of Hawaii, Honolulu, HI (United States)
Brookhaven National Laboratory (BNL), Upton, NY (United States)

Dopamine and dopamine transporters (DAT, which regulate extracellular dopamine in the brain) are implicated in the modulation of attention but their specific roles are not well understood. Here we hypothesized that dopamine modulates attention by facilitation of brain deactivation in the default mode network (DMN). Thus, higher striatal DAT levels, which would result in an enhanced clearance of dopamine and hence weaker dopamine signals, would be associated to lower deactivation in the DMN during an attention task. For this purpose we assessed the relationship between DAT in striatum (measured with positron emission tomography and [11C]cocaine used as DAT radiotracer) and brain activation and deactivation during a parametric visual attention task (measured with blood oxygenation level dependent functional magnetic resonance imaging) in healthy controls. We show that DAT availability in caudate and putamen had a negative correlation with deactivation in ventral parietal regions of the DMN (precuneus, BA 7) and a positive correlation with deactivation in a small region in the ventral anterior cingulate gyrus (BA 24/32). With increasing attentional load, DAT in caudate showed a negative correlation with load-related deactivation increases in precuneus. These findings provide evidence that dopamine transporters modulate neural activity in the DMN and anterior cingulate gyrus during visuospatial attention. Our findings suggest that dopamine modulates attention in part by regulating neuronal activity in posterior parietal cortex including precuneus (region involved in alertness) and cingulate gyrus (region deactivated in proportion to emotional interference). These findings suggest that the beneficial effects of stimulant medications (increase dopamine by blocking DAT) in inattention reflect in part their ability to facilitate the deactivation of the DMN.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Center for Research Resources; National Institutes of Alcoholism and Alcohol Abuse

Grant/Contract Number:: SC0012704; AC-298CH10886; 2RO1AA09481; GCRC 5-MO1-RR-10710

OSTI ID:: 1627378

Journal Information:: PLoS ONE, Vol. 4, Issue 6; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

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Dopamine Transporters in Striatum Correlated with Deactivation in the Default Mode Network during Visuospatial Attention

Journal Article · Mon Jun 01 00:00:00 EDT 2009 · PLoS ONE · OSTI ID:1627378

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Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers: Association to striatal D2/D3 receptors

Journal Article · Wed Aug 20 00:00:00 EDT 2014 · Human Brain Mapping · OSTI ID:1627378

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Systemic injection of kainic acid: Gliosis in olfactory and limbic brain regions quantified with ( sup 3 H)PK 11195 binding autoradiography

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · Experimental Neurology; (USA) · OSTI ID:1627378

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
attention
functional magnetic resonance imaging
magnetic resonance imaging
neostriatum
thalamus
dopamine
position emission tomography
statistical signal processing

Title: Dopamine Transporters in Striatum Correlate with Deactivation in the Default Mode Network during Visuospatial Attention

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