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Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection

Journal Article · · Retrovirology
 [1];  [2];  [3];  [2];  [2];  [3];  [4];  [5];  [3];  [6];  [7]
  1. University of Oxford (United Kingdom); DOE/OSTI
  2. Duke University, Durham, NC (United States)
  3. University of Oxford (United Kingdom)
  4. University of KwaZulu-Natal, Durban (South Africa)
  5. Los Alamos National Laboratory (LANL), Los Alamos, NM (United States); Santa Fe Institute. (SFI), Santa Fe, NM (United States)
  6. Duke University, Durham, NC (United States); Jilin University, Changchun (China
  7. University of North Carolina, Chapel Hill, NC (United States)

A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef. Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER). National Institutes of Health (NIH)
Grant/Contract Number:
AC52-06NA25396
OSTI ID:
1626906
Journal Information:
Retrovirology, Journal Name: Retrovirology Journal Issue: 1 Vol. 11; ISSN 1742-4690
Publisher:
BioMed CentralCopyright Statement
Country of Publication:
United States
Language:
English

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  • The Journal of Infectious Diseases, Vol. 201, Issue 11 https://doi.org/10.1086/652702
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Transmission of Multiple HIV-1 Subtype C Transmitted/founder Viruses into the Same Recipients Was not Determined by Modest Phenotypic Differences journal December 2016
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