A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef. Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.
Ritchie, Adam John, et al. "<strong>Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection</strong>." Retrovirology, vol. 11, no. 1, Sep. 2014. https://doi.org/10.1186/s12977-014-0069-9
@article{osti_1626906,
author = {Ritchie, Adam John and Cai, Fangping and Smith, Nicola MG and Chen, Sheri and Song, Hongshuo and Brackenridge, Simon and Abdool Karim, Salim S. and Korber, Bette T. and McMichael, Andrew J. and Gao, Feng and others},
title = {<strong>Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection</strong>},
annote = {A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef. Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.},
doi = {10.1186/s12977-014-0069-9},
url = {https://www.osti.gov/biblio/1626906},
journal = {Retrovirology},
issn = {ISSN 1742-4690},
number = {1},
volume = {11},
place = {United States},
publisher = {BioMed Central},
year = {2014},
month = {09}}