Archaeal Genome Guardians Give Insights into Eukaryotic DNA Replication and Damage Response Proteins

Shin, David S.; Pratt, Ashley J.; Tainer, John A.

doi:10.1155/2014/206735

Archaeal Genome Guardians Give Insights into Eukaryotic DNA Replication and Damage Response Proteins

Journal Article · Thu Feb 20 00:00:00 EST 2014 · Archaea

DOI:https://doi.org/10.1155/2014/206735· OSTI ID:1626219

Shin, David S. ^[1]; Pratt, Ashley J. ^[2]; Tainer, John A. ^[3]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division; DOE/OSTI
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division; The Scripps Research Inst., La Jolla, CA (United States). Dept. of Integrative Structural and Computational Biology

As the third domain of life, archaea, like the eukarya and bacteria, must have robust DNA replication and repair complexes to ensure genome fidelity. Archaea moreover display a breadth of unique habitats and characteristics, and structural biologists increasingly appreciate these features. As archaea include extremophiles that can withstand diverse environmental stresses, they provide fundamental systems for understanding enzymes and pathways critical to genome integrity and stress responses. Such archaeal extremophiles provide critical data on the periodic table for life as well as on the biochemical, geochemical, and physical limitations to adaptive strategies allowing organisms to thrive under environmental stress relevant to determining the boundaries for life as we know it. Specifically, archaeal enzyme structures have informed the architecture and mechanisms of key DNA repair proteins and complexes. With added abilities to temperature-trap flexible complexes and reveal core domains of transient and dynamic complexes, these structures provide insights into mechanisms of maintaining genome integrity despite extreme environmental stress. The DNA damage response protein structures noted in this review therefore inform the basis for genome integrity in the face of environmental stress, with implications for all domains of life as well as for biomanufacturing, astrobiology, and medicine.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1626219

Journal Information:: Archaea, Journal Name: Archaea Vol. 2014; ISSN 1472-3646

Publisher:: HindawiCopyright Statement

Country of Publication:: United States

Language:: English

References (262)

The puzzle of PCNA's many partners Warbrick, Emma BioEssays, Vol. 22, Issue 11 https://doi.org/10.1002/1521-1878(200011)22:11<997::aid-bies6>3.0.co;2-#	journal	October 2000
The characterization of a mammalian DNA structure-specific endonuclease. Harrington, J. J.; Lieber, M. R. The EMBO Journal, Vol. 13, Issue 5 https://doi.org/10.1002/j.1460-2075.1994.tb06373.x	journal	March 1994
Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure. Thayer, M. M.; Ahern, H.; Xing, D. The EMBO Journal, Vol. 14, Issue 16 https://doi.org/10.1002/j.1460-2075.1995.tb00083.x	journal	August 1995
The N-terminal domain of the human Rad51 protein binds DNA: structure and a DNA binding surface as revealed by NMR Aihara, Hideki; Ito, Yutaka; Kurumizaka, Hitoshi Journal of Molecular Biology, Vol. 290, Issue 2 https://doi.org/10.1006/jmbi.1999.2904	journal	July 1999
Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases Mol, Clifford D.; Arvai, Andrew S.; Begley, Thomas J. Journal of Molecular Biology, Vol. 315, Issue 3 https://doi.org/10.1006/jmbi.2001.5264	journal	January 2002
Readers of PCNA modifications Ulrich, Helle D.; Takahashi, Tomio Chromosoma, Vol. 122, Issue 4 https://doi.org/10.1007/s00412-013-0410-4	journal	April 2013
Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp Kong, Xiang-Peng; Onrust, Rene; O'Donnell, Mike Cell, Vol. 69, Issue 3 https://doi.org/10.1016/0092-8674(92)90445-i	journal	May 1992
DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA Sung, Patrick; Robberson, Donald L. Cell, Vol. 82, Issue 3 https://doi.org/10.1016/0092-8674(95)90434-4	journal	August 1995
PCNA, the Maestro of the Replication Fork Moldovan, George-Lucian; Pfander, Boris; Jentsch, Stefan Cell, Vol. 129, Issue 4 https://doi.org/10.1016/j.cell.2007.05.003	journal	May 2007
Structure of the DNA Repair Helicase XPD Liu, Huanting; Rudolf, Jana; Johnson, Kenneth A. Cell, Vol. 133, Issue 5 https://doi.org/10.1016/j.cell.2008.04.029	journal	May 2008
XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations Fan, Li; Fuss, Jill O.; Cheng, Quen J. Cell, Vol. 133, Issue 5 https://doi.org/10.1016/j.cell.2008.04.030	journal	May 2008
Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair Williams, R. Scott; Dodson, Gerald E.; Limbo, Oliver Cell, Vol. 139, Issue 1 https://doi.org/10.1016/j.cell.2009.07.033	journal	October 2009
Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily Tsutakawa, Susan E.; Classen, Scott; Chapados, Brian R. Cell, Vol. 145, Issue 2 https://doi.org/10.1016/j.cell.2011.03.004	journal	April 2011
DNA Repair: Trust but Verify Spies, Maria Current Biology, Vol. 23, Issue 3 https://doi.org/10.1016/j.cub.2012.12.019	journal	February 2013
DNA polymerases and repair synthesis in NER in human cells Lehmann, Alan R. DNA Repair, Vol. 10, Issue 7 https://doi.org/10.1016/j.dnarep.2011.04.023	journal	July 2011
Contribution of Electrostatic Interactions, Compactness and Quaternary Structure to Protein Thermostability: Lessons from Structural Genomics of Thermotoga maritima Robinson-Rechavi, Marc; Alibés, Andreu; Godzik, Adam Journal of Molecular Biology, Vol. 356, Issue 2 https://doi.org/10.1016/j.jmb.2005.11.065	journal	February 2006
Crystal Structure of Family 5 Uracil-DNA Glycosylase Bound to DNA Kosaka, Hiromichi; Hoseki, Jun; Nakagawa, Noriko Journal of Molecular Biology, Vol. 373, Issue 4 https://doi.org/10.1016/j.jmb.2007.08.022	journal	November 2007
Uracil Recognition in Archaeal DNA Polymerases Captured by X-ray Crystallography Firbank, Susan J.; Wardle, Josephine; Heslop, Pauline Journal of Molecular Biology, Vol. 381, Issue 3 https://doi.org/10.1016/j.jmb.2008.06.004	journal	September 2008
Superoxide Dismutase from the Eukaryotic Thermophile Alvinella pompejana: Structures, Stability, Mechanism, and Insights into Amyotrophic Lateral Sclerosis Shin, David S.; DiDonato, Michael; Barondeau, David P. Journal of Molecular Biology, Vol. 385, Issue 5 https://doi.org/10.1016/j.jmb.2008.11.031	journal	February 2009
The DNA Repair Helicases XPD and FancJ Have Essential Iron-Sulfur Domains Rudolf, Jana; Makrantoni, Vasso; Ingledew, W. John Molecular Cell, Vol. 23, Issue 6 https://doi.org/10.1016/j.molcel.2006.07.019	journal	September 2006
Insights into FlaI Functions in Archaeal Motor Assembly and Motility from Structures, Conformations, and Genetics Reindl, Sophia; Ghosh, Abhrajyoti; Williams, Gareth J. Molecular Cell, Vol. 49, Issue 6 https://doi.org/10.1016/j.molcel.2013.01.014	journal	March 2013
Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities Edelbrock, Michael A.; Kaliyaperumal, Saravanan; Williams, Kandace J. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 743-744 https://doi.org/10.1016/j.mrfmmm.2012.12.008	journal	March 2013
Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations Park, Young Bong; Chae, Jina; Kim, Young Chang Structure, Vol. 19, Issue 11 https://doi.org/10.1016/j.str.2011.09.010	journal	November 2011
Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases Grasby, Jane A.; Finger, L. David; Tsutakawa, Susan E. Trends in Biochemical Sciences, Vol. 37, Issue 2 https://doi.org/10.1016/j.tibs.2011.10.003	journal	February 2012
The cell cycle and DNA mismatch repair Schroering, Allen G.; Edelbrock, Michael A.; Richards, Timothy J. Experimental Cell Research, Vol. 313, Issue 2 https://doi.org/10.1016/j.yexcr.2006.10.018	journal	January 2007
ALS Mutants of Human Superoxide Dismutase Form Fibrous Aggregates Via Framework Destabilization DiDonato, Michael; Craig, Lisa; Huff, Mary E. Journal of Molecular Biology, Vol. 332, Issue 3 https://doi.org/10.1016/s0022-2836(03)00889-1	journal	September 2003
Archaea and the Origin(s) of DNA Replication Proteins Edgell, David R.; Doolittle, W. Ford Cell, Vol. 89, Issue 7 https://doi.org/10.1016/s0092-8674(00)80285-8	journal	June 1997
Archaeal Histones, Nucleosomes, and Transcription Initiation Reeve, John N.; Sandman, Kathleen; Daniels, Charles J. Cell, Vol. 89, Issue 7 https://doi.org/10.1016/s0092-8674(00)80286-x	journal	June 1997
Structural Biochemistry and Interaction Architecture of the DNA Double-Strand Break Repair Mre11 Nuclease and Rad50-ATPase Hopfner, Karl-Peter; Karcher, Annette; Craig, Lisa Cell, Vol. 105, Issue 4 https://doi.org/10.1016/s0092-8674(01)00335-x	journal	May 2001
Structure and function in the uracil-DNA glycosylase superfamily Pearl, Laurence H. Mutation Research/DNA Repair, Vol. 460, Issue 3-4 https://doi.org/10.1016/s0921-8777(00)00025-2	journal	August 2000
New understandings of thermostable and peizostable enzymes Yano, Jason K.; Poulos, Thomas L. Current Opinion in Biotechnology, Vol. 14, Issue 4 https://doi.org/10.1016/s0958-1669(03)00075-2	journal	August 2003
Comparative biochemistry of Archaea and Bacteria Zillig, Wolfram Current Opinion in Genetics & Development, Vol. 1, Issue 4 https://doi.org/10.1016/s0959-437x(05)80206-0	journal	December 1991
Crystal Structure of the Archaeal Holliday Junction Resolvase Hjc and Implications for DNA Recognition Nishino, Tatsuya; Komori, Kayoko; Tsuchiya, Daisuke Structure, Vol. 9, Issue 3 https://doi.org/10.1016/s0969-2126(01)00576-7	journal	March 2001
Structural Basis for Octameric Ring Formation and DNA Interaction of the Human Homologous-Pairing Protein Dmc1 Kinebuchi, Takashi; Kagawa, Wataru; Enomoto, Rima Molecular Cell, Vol. 14, Issue 3 https://doi.org/10.1016/s1097-2765(04)00218-7	journal	May 2004
Inhibition of Rad3 DNA helicase activity by DNA adducts and abasic sites: implications for the role of a DNA helicase in damage-specific incision of DNA Naegeli, Hanspeter; Bardwell, Lee; Friedberg, Errol C. Biochemistry, Vol. 32, Issue 2 https://doi.org/10.1021/bi00053a029	journal	January 1993
Crystal Structures of Human DNA Polymerase β Complexed with DNA: Implications for Catalytic Mechanism, Processivity, and Fidelity ^† ^, ^‡ Pelletier, Huguette; Sawaya, Michael R.; Wolfle, William Biochemistry, Vol. 35, Issue 39 https://doi.org/10.1021/bi952955d	journal	January 1996
ATP-Stimulated, DNA-Mediated Redox Signaling by XPD, a DNA Repair and Transcription Helicase Mui, Timothy P.; Fuss, Jill O.; Ishida, Justin P. Journal of the American Chemical Society, Vol. 133, Issue 41 https://doi.org/10.1021/ja207222t	journal	October 2011
A scaleable and integrated crystallization pipeline applied to mining the Thermotoga maritima proteome DiDonato, Michael; Deacon, Ashley M.; Klock, Heath E. Journal of Structural and Functional Genomics, Vol. 5, Issue 1/2 https://doi.org/10.1023/b:jsfg.0000029194.04443.50	journal	March 2004
Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I Lima, Christopher D.; Wang, James C.; Mondragón, Alfonso Nature, Vol. 367, Issue 6459 https://doi.org/10.1038/367138a0	journal	January 1994
Crystal structure of the breakage–reunion domain of DNA gyrase Cabral, Joo H. Morais; Jackson, Andrew P.; Smith, Clare V. Nature, Vol. 388, Issue 6645 https://doi.org/10.1038/42294	journal	August 1997
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair Hopfner, Karl-Peter; Craig, Lisa; Moncalian, Gabriel Nature, Vol. 418, Issue 6897 https://doi.org/10.1038/nature00922	journal	August 2002
Structural visualization of key steps in human transcription initiation He, Yuan; Fang, Jie; Taatjes, Dylan J. Nature, Vol. 495, Issue 7442 https://doi.org/10.1038/nature11991	journal	February 2013
Cadmium is a mutagen that acts by inhibiting mismatch repair Jin, Yong Hwan; Clark, Alan B.; Slebos, Robbert J. C. Nature Genetics, Vol. 34, Issue 3 https://doi.org/10.1038/ng1172	journal	June 2003
Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS) Hura, Greg L.; Menon, Angeli L.; Hammel, Michal Nature Methods, Vol. 6, Issue 8 https://doi.org/10.1038/nmeth.1353	journal	July 2009
The replication clamp-loading machine at work in the three domains of life Indiani, Chiara; O'Donnell, Mike Nature Reviews Molecular Cell Biology, Vol. 7, Issue 10 https://doi.org/10.1038/nrm2022	journal	September 2006
Structural basis for uracil recognition by archaeal family B DNA polymerases Fogg, Mark J.; Pearl, Laurence H.; Connolly, Bernard A. Nature Structural Biology, Vol. 9, Issue 12 https://doi.org/10.1038/nsb867	journal	November 2002
Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA Leiros, Ingar; Nabong, Marivi P.; Grøsvik, Kristin The EMBO Journal, Vol. 26, Issue 8 https://doi.org/10.1038/sj.emboj.7601662	journal	March 2007
MlaA, a hexameric ATPase linked to the Mre11 complex in archaeal genomes Manzan, Angelo; Pfeiffer, Günter; Hefferin, Melissa L. EMBO reports, Vol. 5, Issue 1 https://doi.org/10.1038/sj.embor.7400037	journal	January 2004
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks Zheng, Li; Zhou, Mian; Chai, Qing EMBO reports, Vol. 6, Issue 1 https://doi.org/10.1038/sj.embor.7400313	journal	January 2005
Tumor progression in Apc1638N mice with Exo1 and Fen1 deficiencies Kucherlapati, M.; Nguyen, A.; Kuraguchi, M. Oncogene, Vol. 26, Issue 43 https://doi.org/10.1038/sj.onc.1210453	journal	April 2007
DNA replication in thermophiles Majerník, A. I.; Jenkinson, E. R.; Chong, J. P. J. Biochemical Society Transactions, Vol. 32, Issue 2 https://doi.org/10.1042/bst0320236	journal	April 2004
The role of the DNA sliding clamp in Okazaki fragment maturation in archaea and eukaryotes Beattie, Thomas R.; Bell, Stephen D. Biochemical Society Transactions, Vol. 39, Issue 1 https://doi.org/10.1042/bst0390070	journal	January 2011
Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase Mathieu, Nadine; Kaczmarek, Nina; Naegeli, Hanspeter Proceedings of the National Academy of Sciences, Vol. 107, Issue 41 https://doi.org/10.1073/pnas.1004339107	journal	September 2010
Phylogeny and beyond: Scientific, historical, and conceptual significance of the first tree of life Pace, N. R.; Sapp, J.; Goldenfeld, N. Proceedings of the National Academy of Sciences, Vol. 109, Issue 4 https://doi.org/10.1073/pnas.1109716109	journal	January 2012
Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA Tsutakawa, S. E.; Van Wynsberghe, A. W.; Freudenthal, B. D. Proceedings of the National Academy of Sciences, Vol. 108, Issue 43 https://doi.org/10.1073/pnas.1110480108	journal	October 2011
Phylogenetic structure of the prokaryotic domain: The primary kingdoms Woese, C. R.; Fox, G. E. Proceedings of the National Academy of Sciences, Vol. 74, Issue 11 https://doi.org/10.1073/pnas.74.11.5088	journal	November 1977
Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. Woese, C. R.; Kandler, O.; Wheelis, M. L. Proceedings of the National Academy of Sciences, Vol. 87, Issue 12 https://doi.org/10.1073/pnas.87.12.4576	journal	June 1990
An extended DNA structure through deoxyribose-base stacking induced by RecA protein Nishinaka, T.; Ito, Y.; Yokoyama, S. Proceedings of the National Academy of Sciences, Vol. 94, Issue 13 https://doi.org/10.1073/pnas.94.13.6623	journal	June 1997
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment Chen, P. -L.; Chen, C. -F.; Chen, Y. Proceedings of the National Academy of Sciences, Vol. 95, Issue 9 https://doi.org/10.1073/pnas.95.9.5287	journal	April 1998
Calf RTH-1 Nuclease Can Remove the Initiator RNAs of Okazaki Fragments by Endonuclease Activity Murante, Richard S.; Rumbaugh, Jeffrey A.; Barnes, Carole J. Journal of Biological Chemistry, Vol. 271, Issue 42 https://doi.org/10.1074/jbc.271.42.25888	journal	October 1996
Human RAD2 Homolog 1 5′- to 3′-Exo/Endonuclease Can Efficiently Excise a Displaced DNA Fragment Containing a 5′-Terminal Abasic Lesion by Endonuclease Activity DeMott, Michael S.; Shen, Binghui; Park, Min S. Journal of Biological Chemistry, Vol. 271, Issue 47 https://doi.org/10.1074/jbc.271.47.30068	journal	November 1996
Enzymes and Reactions at the Eukaryotic DNA Replication Fork Bambara, Robert A.; Murante, Richard S.; Henricksen, Leigh A. Journal of Biological Chemistry, Vol. 272, Issue 8 https://doi.org/10.1074/jbc.272.8.4647	journal	February 1997
A Comparison of Eubacterial and Archaeal Structure-specific 5′-Exonucleases Kaiser, Michael W.; Lyamicheva, Natasha; Ma, Wupo Journal of Biological Chemistry, Vol. 274, Issue 30 https://doi.org/10.1074/jbc.274.30.21387	journal	July 1999
Biochemical Characterization of Uracil Processing Activities in the Hyperthermophilic Archaeon Pyrobaculum aerophilum Sartori, Alessandro A.; Schär, Primo; Fitz-Gibbon, Sorel Journal of Biological Chemistry, Vol. 276, Issue 32 https://doi.org/10.1074/jbc.m102985200	journal	August 2001
New Family of Deamination Repair Enzymes in Uracil-DNA Glycosylase Superfamily Lee, Hyun-Wook; Dominy, Brian N.; Cao, Weiguo Journal of Biological Chemistry, Vol. 286, Issue 36 https://doi.org/10.1074/jbc.m111.249524	journal	June 2011
The Iron-containing Domain Is Essential in Rad3 Helicases for Coupling of ATP Hydrolysis to DNA Translocation and for Targeting the Helicase to the Single-stranded DNA-Double-stranded DNA Junction Pugh, Robert A.; Honda, Masayoshi; Leesley, Haley Journal of Biological Chemistry, Vol. 283, Issue 3 https://doi.org/10.1074/jbc.m707064200	journal	January 2008
Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein Kerr, I. D. The EMBO Journal, Vol. 22, Issue 11 https://doi.org/10.1093/emboj/cdg272	journal	June 2003
CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation Parrish, J. Z. The EMBO Journal, Vol. 22, Issue 13 https://doi.org/10.1093/emboj/cdg320	journal	July 2003
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2 Shin, D. S. The EMBO Journal, Vol. 22, Issue 17 https://doi.org/10.1093/emboj/cdg429	journal	September 2003
Phylogenomic Analysis of the Uracil-DNA Glycosylase Superfamily Lucas-Lledo, J. I.; Maddamsetti, R.; Lynch, M. Molecular Biology and Evolution, Vol. 28, Issue 3 https://doi.org/10.1093/molbev/msq318	journal	December 2010
A DNA polymerase from the archaeon Sulfolobus solfataricus shows sequence similarity to family B DNA polymerases Pisani, Francesca M.; Martino, Ciro De; Rossi, Mosè Nucleic Acids Research, Vol. 20, Issue 11 https://doi.org/10.1093/nar/20.11.2711	journal	January 1992
recA-like genes from three archaean species with putative protein products similar to Rad51 and Dmc1 proteins of the yeast Saccharomyces cerevisiae Sandler, S. Nucleic Acids Research, Vol. 24, Issue 11 https://doi.org/10.1093/nar/24.11.2125	journal	June 1996
Identification and properties of the crenarchaeal single-stranded DNA binding protein from Sulfolobus solfataricus Wadsworth, R. I. M. Nucleic Acids Research, Vol. 29, Issue 4 https://doi.org/10.1093/nar/29.4.914	journal	February 2001
A novel uracil-DNA glycosylase family related to the helix-hairpin-helix DNA glycosylase superfamily Chung, J. H. Nucleic Acids Research, Vol. 31, Issue 8 https://doi.org/10.1093/nar/gkg319	journal	April 2003
ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex Möckel, Carolin; Lammens, Katja; Schele, Alexandra Nucleic Acids Research, Vol. 40, Issue 2 https://doi.org/10.1093/nar/gkr749	journal	September 2011
Unwinding of primer-templates by archaeal family-B DNA polymerases in response to template-strand uracil Richardson, Tomas T.; Wu, Xiaohua; Keith, Brian J. Nucleic Acids Research, Vol. 41, Issue 4 https://doi.org/10.1093/nar/gks1364	journal	January 2013
Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair Limbo, Oliver; Moiani, Davide; Kertokalio, Aryandi Nucleic Acids Research, Vol. 40, Issue 22 https://doi.org/10.1093/nar/gks954	journal	October 2012
Novel inhibition of archaeal family-D DNA polymerase by uracil Richardson, Tomas T.; Gilroy, Louise; Ishino, Yoshizumi Nucleic Acids Research, Vol. 41, Issue 7 https://doi.org/10.1093/nar/gkt083	journal	February 2013
Selenocysteine's mechanism of incorporation and evolution revealed in cDNAs of three glutathione peroxidases Mullenbach, Guy T.; Tabrizi, Azita; Irvine, Bruce D. "Protein Engineering, Design and Selection", Vol. 2, Issue 3 https://doi.org/10.1093/protein/2.3.239	journal	January 1988
Structure and conformational change of a replication protein A heterotrimer bound to ssDNA Fan, J.; Pavletich, N. P. Genes & Development, Vol. 26, Issue 20 https://doi.org/10.1101/gad.194787.112	journal	October 2012
The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseases Lehmann, A. R. Genes & Development, Vol. 15, Issue 1 https://doi.org/10.1101/gad.859501	journal	January 2001
Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source Classen, Scott; Hura, Greg L.; Holton, James M. Journal of Applied Crystallography, Vol. 46, Issue 1 https://doi.org/10.1107/s0021889812048698	journal	January 2013
Problems with “Procaryote” Pace, Norman R. Journal of Bacteriology, Vol. 191, Issue 7 https://doi.org/10.1128/jb.01224-08	journal	January 2009
Disruption of the FEN-1/PCNA Interaction Results in DNA Replication Defects, Pulmonary Hypoplasia, Pancytopenia, and Newborn Lethality in Mice Zheng, Li; Dai, Huifang; Qiu, Junzhuan Molecular and Cellular Biology, Vol. 27, Issue 8 https://doi.org/10.1128/mcb.01652-06	journal	February 2007
A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Lim, D. S.; Hasty, P. Molecular and Cellular Biology, Vol. 16, Issue 12 https://doi.org/10.1128/mcb.16.12.7133	journal	December 1996
Super-Resolution in Solution X-Ray Scattering and Its Applications to Structural Systems Biology Rambo, Robert P.; Tainer, John A. Annual Review of Biophysics, Vol. 42, Issue 1 https://doi.org/10.1146/annurev-biophys-083012-130301	journal	May 2013
Selenocysteine Stadtman, Thressa C. Annual Review of Biochemistry, Vol. 65, Issue 1 https://doi.org/10.1146/annurev.bi.65.070196.000503	journal	June 1996
A Computational Framework for Proteome-Wide Pursuit and Prediction of Metalloproteins using ICP-MS and MS/MS Data Lancaster, W. Andrew; Praissman, Jeremy L.; Poole, Farris L. BMC Bioinformatics, Vol. 12, Issue 1 https://doi.org/10.1186/1471-2105-12-64	journal	February 2011
ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining Rahal, Elias A.; Henricksen, Leigh A.; Li, Yuling Cell Cycle, Vol. 9, Issue 14 https://doi.org/10.4161/cc.9.14.12363	journal	July 2010
The puzzle of PCNA's many partners Warbrick, Emma BioEssays, Vol. 22, Issue 11 https://doi.org/10.1002/1521-1878(200011)22:11<997::AID-BIES6>3.0.CO;2-#	journal	October 2000
Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases Shen, Binghui; Singh, Purnima; Liu, Ren BioEssays, Vol. 27, Issue 7 https://doi.org/10.1002/bies.20255	journal	January 2005
Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law Rambo, Robert P.; Tainer, John A. Biopolymers, Vol. 95, Issue 8 https://doi.org/10.1002/bip.21638	journal	April 2011
Using a Fragment-Based Approach To Target Protein-Protein Interactions Scott, Duncan E.; Ehebauer, Matthias T.; Pukala, Tara ChemBioChem, Vol. 14, Issue 3 https://doi.org/10.1002/cbic.201200521	journal	January 2013
ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling Deshpande, R. A.; Williams, G. J.; Limbo, O. The EMBO Journal, Vol. 33, Issue 5 https://doi.org/10.1002/embj.201386100	journal	February 2014
Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA. Benson, F. E.; Stasiak, A.; West, S. C. The EMBO Journal, Vol. 13, Issue 23 https://doi.org/10.1002/j.1460-2075.1994.tb06914.x	journal	December 1994
Archaeoglobus fulgidus RNase HII in DNA Replication: Enzymological Functions and Activity Regulation via Metal Cofactors Chai, Qing; Qiu, Junzhuan; Chapados, Brian R. Biochemical and Biophysical Research Communications, Vol. 286, Issue 5 https://doi.org/10.1006/bbrc.2001.5523	journal	September 2001
Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase 1 1Edited by D. C. Rees Putnam, Christopher D.; Shroyer, Mary Jane N.; Lundquist, Amy J. Journal of Molecular Biology, Vol. 287, Issue 2 https://doi.org/10.1006/jmbi.1999.2605	journal	March 1999
Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication11Edited by K. Morikawa Chapados, Brian R.; Chai, Qing; Hosfield, David J. Journal of Molecular Biology, Vol. 307, Issue 2 https://doi.org/10.1006/jmbi.2001.4494	journal	March 2001
Structure and mechanism of the RuvB holliday junction branch migration motor Putnam, Christopher D.; Clancy, Sheila B.; Tsuruta, Hiro Journal of Molecular Biology, Vol. 311, Issue 2 https://doi.org/10.1006/jmbi.2001.4852	journal	August 2001
Comparison of bacteriophage T4 UvsX and human Rad51 filaments suggests that RecA-like polymers may have evolved independently11Edited by M. Belfort Yang, Shixin; VanLoock, Margaret S.; Yu, Xiong Journal of Molecular Biology, Vol. 312, Issue 5 https://doi.org/10.1006/jmbi.2001.5025	journal	October 2001
A novel repair enzyme: UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region Sancar, Aziz; Rupp, W. Dean Cell, Vol. 33, Issue 1 https://doi.org/10.1016/0092-8674(83)90354-9	journal	May 1983
Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp Kong, Xiang-Peng; Onrust, Rene; O'Donnell, Mike Cell, Vol. 69, Issue 3 https://doi.org/10.1016/0092-8674(92)90445-I	journal	May 1992
Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA Krishna, Talluru S. R.; Kong, Xiang-Peng; Gary, Sonja Cell, Vol. 79, Issue 7 https://doi.org/10.1016/0092-8674(94)90014-0	journal	December 1994
Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine. McRee, D. E.; Redford, S. M.; Getzoff, E. D. Journal of Biological Chemistry, Vol. 265, Issue 24 https://doi.org/10.1016/S0021-9258(18)77291-8	journal	August 1990
Structural Basis for Recognition and Catalysis by the Bifunctional dCTP Deaminase and dUTPase from Methanococcus jannaschii Huffman, Joy L.; Li, Hong; White, Robert H. Journal of Molecular Biology, Vol. 331, Issue 4 https://doi.org/10.1016/S0022-2836(03)00789-7	journal	August 2003
Erratum to “ALS Mutants of Human Superoxide Dismutase form Fibrous Aggregates via Framework Destabilization” [J. Mol. Biol. 332 (2003) 601–615] DiDonato, Michael; Craig, Lisa; Huff, Mary E. Journal of Molecular Biology, Vol. 334, Issue 1 https://doi.org/10.1016/S0022-2836(03)01190-2	journal	November 2003
The mechanism of switching among multiple BER pathways Dogliotti, Eugenia; Fortini, Paola; Pascucci, Barbara Base Excision Repair https://doi.org/10.1016/S0079-6603(01)68086-3	book	January 2001
Molecular mechanism of PCNA-dependent base excision repair Matsumoto, Yoshihiro Base Excision Repair https://doi.org/10.1016/S0079-6603(01)68095-4	book	January 2001
DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes Hosfield, David J.; Daniels, Douglas S.; Mol, Clifford D. Base Excision Repair https://doi.org/10.1016/S0079-6603(01)68110-8	book	January 2001
Archaeal Genomics: An Overview Olsen, Gary J.; Woese, Carl R. Cell, Vol. 89, Issue 7 https://doi.org/10.1016/S0092-8674(00)80284-6	journal	June 1997
Archaea and the Origin(s) of DNA Replication Proteins Edgell, David R.; Doolittle, W. Ford Cell, Vol. 89, Issue 7 https://doi.org/10.1016/S0092-8674(00)80285-8	journal	June 1997
Archaeal Histones, Nucleosomes, and Transcription Initiation Reeve, John N.; Sandman, Kathleen; Daniels, Charles J. Cell, Vol. 89, Issue 7 https://doi.org/10.1016/S0092-8674(00)80286-X	journal	June 1997
Ancient Ciphers: Translation in Archaea Dennis, Patrick P. Cell, Vol. 89, Issue 7 https://doi.org/10.1016/S0092-8674(00)80288-3	journal	June 1997
Structural Biology of Rad50 ATPase Hopfner, Karl-Peter; Karcher, Annette; Shin, David S. Cell, Vol. 101, Issue 7 https://doi.org/10.1016/S0092-8674(00)80890-9	journal	June 2000
Crystal Structure of a G:T/U Mismatch-Specific DNA Glycosylase Barrett, Tracey E.; Savva, Renos; Panayotou, George Cell, Vol. 92, Issue 1 https://doi.org/10.1016/S0092-8674(00)80904-6	journal	January 1998
Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA Gulbis, Jacqueline M.; Kelman, Zvi; Hurwitz, Jerard Cell, Vol. 87, Issue 2 https://doi.org/10.1016/S0092-8674(00)81347-1	journal	October 1996
Structure of the DNA Repair and Replication Endonuclease and Exonuclease FEN-1 Hosfield, David J.; Mol, Clifford D.; Shen, Binghui Cell, Vol. 95, Issue 1 https://doi.org/10.1016/S0092-8674(00)81789-4	journal	October 1998
Structural Biochemistry and Interaction Architecture of the DNA Double-Strand Break Repair Mre11 Nuclease and Rad50-ATPase Hopfner, Karl-Peter; Karcher, Annette; Craig, Lisa Cell, Vol. 105, Issue 4 https://doi.org/10.1016/S0092-8674(01)00335-X	journal	May 2001
Cancer Susceptibility and the Functions of BRCA1 and BRCA2 Venkitaraman, Ashok R. Cell, Vol. 108, Issue 2 https://doi.org/10.1016/S0092-8674(02)00615-3	journal	January 2002
Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair Chapados, Brian R.; Hosfield, David J.; Han, Seungil Cell, Vol. 116, Issue 1 https://doi.org/10.1016/S0092-8674(03)01036-5	journal	January 2004
Multiprotein reactions in mammalian DNA replication Henricksen, Leigh A.; Bambara, Robert A. Leukemia Research, Vol. 22, Issue 1 https://doi.org/10.1016/S0145-2126(97)00113-6	journal	January 1998
Structure and function in the uracil-DNA glycosylase superfamily Pearl, Laurence H. Mutation Research/DNA Repair, Vol. 460, Issue 3-4 https://doi.org/10.1016/S0921-8777(00)00025-2	journal	August 2000
New understandings of thermostable and peizostable enzymes Yano, Jason K.; Poulos, Thomas L. Current Opinion in Biotechnology, Vol. 14, Issue 4 https://doi.org/10.1016/S0958-1669(03)00075-2	journal	August 2003
Comparative biochemistry of Archaea and Bacteria Zillig, Wolfram Current Opinion in Genetics & Development, Vol. 1, Issue 4 https://doi.org/10.1016/S0959-437X(05)80206-0	journal	December 1991
Flap endonuclease 1: a novel tumour suppresser protein Henneke, Ghislaine; Friedrich-Heineken, Erica; Hübscher, Ulrich Trends in Biochemical Sciences, Vol. 28, Issue 7 https://doi.org/10.1016/S0968-0004(03)00138-5	journal	July 2003
Novel homologs of replication protein A in Archaea: implications for the evolution of ssDNA-binding proteins Chédin, Frédéric; Seitz, Erica M.; Kowalczykowski, Stephen C. Trends in Biochemical Sciences, Vol. 23, Issue 8 https://doi.org/10.1016/S0968-0004(98)01243-2	journal	August 1998
Crystal Structure of the Archaeal Holliday Junction Resolvase Hjc and Implications for DNA Recognition Nishino, Tatsuya; Komori, Kayoko; Tsuchiya, Daisuke Structure, Vol. 9, Issue 3 https://doi.org/10.1016/S0969-2126(01)00576-7	journal	March 2001
ATP-Mediated Conformational Changes in the RecA Filament VanLoock, Margaret S.; Yu, Xiong; Yang, Shixin Structure, Vol. 11, Issue 2 https://doi.org/10.1016/S0969-2126(03)00003-0	journal	February 2003
Clinical, genetic, and pharmacogenetic applications of the invader assay* Kwiatkowski, R.; Lyamichev, V.; Dearruda, M. Molecular Diagnosis, Vol. 4, Issue 4 https://doi.org/10.1016/S1084-8592(99)80012-5	journal	December 1999
Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein Davies, Adelina A.; Masson, Jean-Yves; McIlwraith, Michael J. Molecular Cell, Vol. 7, Issue 2 https://doi.org/10.1016/S1097-2765(01)00175-7	journal	February 2001
Human Rad50/Mre11 Is a Flexible Complex that Can Tether DNA Ends de Jager, Martijn; van Noort, John; van Gent, Dik C. Molecular Cell, Vol. 8, Issue 5 https://doi.org/10.1016/S1097-2765(01)00381-1	journal	November 2001
A Heterotrimeric PCNA in the Hyperthermophilic Archaeon Sulfolobus solfataricus Dionne, Isabelle; Nookala, Ravi K.; Jackson, Stephen P. Molecular Cell, Vol. 11, Issue 1 https://doi.org/10.1016/S1097-2765(02)00824-9	journal	January 2003
Structure and Specificity of the Vertebrate Anti-Mutator Uracil-DNA Glycosylase SMUG1 Wibley, Jane E. A.; Waters, Timothy R.; Haushalter, Karl Molecular Cell, Vol. 11, Issue 6 https://doi.org/10.1016/S1097-2765(03)00235-1	journal	June 2003
Structural Basis for Octameric Ring Formation and DNA Interaction of the Human Homologous-Pairing Protein Dmc1 Kinebuchi, Takashi; Kagawa, Wataru; Enomoto, Rima Molecular Cell, Vol. 14, Issue 3 https://doi.org/10.1016/S1097-2765(04)00218-7	journal	May 2004
The structural biochemistry of the superoxide dismutases Perry, J. J. P.; Shin, D. S.; Getzoff, E. D. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1804, Issue 2 https://doi.org/10.1016/j.bbapap.2009.11.004	journal	February 2010
Base excision repair and cancer Wallace, Susan S.; Murphy, Drew L.; Sweasy, Joann B. Cancer Letters, Vol. 327, Issue 1-2 https://doi.org/10.1016/j.canlet.2011.12.038	journal	December 2012
The P. furiosus Mre11/Rad50 Complex Promotes 5′ Strand Resection at a DNA Double-Strand Break Hopkins, Ben B.; Paull, Tanya T. Cell, Vol. 135, Issue 2 https://doi.org/10.1016/j.cell.2008.09.054	journal	October 2008
A Supramodular FHA/BRCT-Repeat Architecture Mediates Nbs1 Adaptor Function in Response to DNA Damage Lloyd, Janette; Chapman, J. Ross; Clapperton, Julie A. Cell, Vol. 139, Issue 1 https://doi.org/10.1016/j.cell.2009.07.043	journal	October 2009
Metals in biology: defining metalloproteomes Yannone, Steven M.; Hartung, Sophia; Menon, Angeli L. Current Opinion in Biotechnology, Vol. 23, Issue 1 https://doi.org/10.1016/j.copbio.2011.11.005	journal	February 2012
DNA Quality Control by a Lesion Sensor Pocket of the Xeroderma Pigmentosum Group D Helicase Subunit of TFIIH Mathieu, Nadine; Kaczmarek, Nina; Rüthemann, Peter Current Biology, Vol. 23, Issue 3 https://doi.org/10.1016/j.cub.2012.12.032	journal	February 2013
Structure and function of the double-strand break repair machinery Shin, David S.; Chahwan, Charly; Huffman, Joy L. DNA Repair, Vol. 3, Issue 8-9 https://doi.org/10.1016/j.dnarep.2004.03.022	journal	August 2004
The intricate structural chemistry of base excision repair machinery: Implications for DNA damage recognition, removal, and repair Hitomi, Kenichi; Iwai, Shigenori; Tainer, John A. DNA Repair, Vol. 6, Issue 4 https://doi.org/10.1016/j.dnarep.2006.10.004	journal	April 2007
Uracil in DNA—General mutagen, but normal intermediate in acquired immunity Kavli, B.; Otterlei, M.; Slupphaug, G. DNA Repair, Vol. 6, Issue 4 https://doi.org/10.1016/j.dnarep.2006.10.014	journal	April 2007
XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase Fuss, Jill O.; Tainer, John A. DNA Repair, Vol. 10, Issue 7 https://doi.org/10.1016/j.dnarep.2011.04.028	journal	July 2011
DNA repair mechanisms in dividing and non-dividing cells Iyama, Teruaki; Wilson, David M. DNA Repair, Vol. 12, Issue 8 https://doi.org/10.1016/j.dnarep.2013.04.015	journal	August 2013
Characterization and PCR applications of dUTPase from the hyperthermophilic euryarchaeon Thermococcus pacificus Cho, Sung Suk; Sun, Younguk; Yu, Mi Enzyme and Microbial Technology, Vol. 51, Issue 6-7 https://doi.org/10.1016/j.enzmictec.2012.08.001	journal	December 2012
Crystal Structure of a Family 4 Uracil-DNA Glycosylase from Thermus thermophilus HB8 Hoseki, Jun; Okamoto, Akihiro; Masui, Ryoji Journal of Molecular Biology, Vol. 333, Issue 3 https://doi.org/10.1016/j.jmb.2003.08.030	journal	October 2003
The Rad50 Signature Motif: Essential to ATP Binding and Biological Function Moncalian, Gabriel; Lengsfeld, Bettina; Bhaskara, Venugopal Journal of Molecular Biology, Vol. 335, Issue 4 https://doi.org/10.1016/j.jmb.2003.11.026	journal	January 2004
Recognition of the Pro-mutagenic Base Uracil by Family B DNA Polymerases from Archaea Shuttleworth, Gillian; Fogg, Mark J.; Kurpiewski, Michael R. Journal of Molecular Biology, Vol. 337, Issue 3 https://doi.org/10.1016/j.jmb.2004.01.021	journal	March 2004
Structure of a Second BRCT Domain Identified in the Nijmegen Breakage Syndrome Protein Nbs1 and its Function in an MDC1-Dependent Localization of Nbs1 to DNA Damage Sites Xu, Chao; Wu, Liming; Cui, Gaofeng Journal of Molecular Biology, Vol. 381, Issue 2 https://doi.org/10.1016/j.jmb.2008.05.087	journal	August 2008
Crystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that May Discriminate Substrates During DNA Repair Das, Debanu; Moiani, Davide; Axelrod, Herbert L. Journal of Molecular Biology, Vol. 397, Issue 3 https://doi.org/10.1016/j.jmb.2010.01.049	journal	April 2010
The Structure of the CRISPR-Associated Protein Csa3 Provides Insight into the Regulation of the CRISPR/Cas System Lintner, Nathanael G.; Frankel, Kenneth A.; Tsutakawa, Susan E. Journal of Molecular Biology, Vol. 405, Issue 4 https://doi.org/10.1016/j.jmb.2010.11.019	journal	January 2011
A novel heterotetrameric structure of the crenarchaeal PCNA2–PCNA3 complex Kawai, Akito; Hashimoto, Hiroshi; Higuchi, Shigesada Journal of Structural Biology, Vol. 174, Issue 3 https://doi.org/10.1016/j.jsb.2011.02.006	journal	June 2011
Industrial relevance of thermophilic Archaea Egorova, Ksenia; Antranikian, Garabed Current Opinion in Microbiology, Vol. 8, Issue 6, p. 649-655 https://doi.org/10.1016/j.mib.2005.10.015	journal	December 2005
Crystal Structure of Archaeal Recombinase RadA Wu, Yan; He, Yujiong; Moya, Ignace A. Molecular Cell, Vol. 15, Issue 3 https://doi.org/10.1016/j.molcel.2004.07.014	journal	August 2004
Recognition of RNA Polymerase II and Transcription Bubbles by XPG, CSB, and TFIIH: Insights for Transcription-Coupled Repair and Cockayne Syndrome Sarker, Altaf H.; Tsutakawa, Susan E.; Kostek, Seth Molecular Cell, Vol. 20, Issue 2 https://doi.org/10.1016/j.molcel.2005.09.022	journal	October 2005
Conserved XPB Core Structure and Motifs for DNA Unwinding: Implications for Pathway Selection of Transcription or Excision Repair Fan, Li; Arvai, Andrew S.; Cooper, Priscilla K. Molecular Cell, Vol. 22, Issue 1 https://doi.org/10.1016/j.molcel.2006.02.017	journal	April 2006
A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA Pascal, John M.; Tsodikov, Oleg V.; Hura, Greg L. Molecular Cell, Vol. 24, Issue 2 https://doi.org/10.1016/j.molcel.2006.08.015	journal	October 2006
New Functions for Y Family Polymerases Lehmann, Alan R. Molecular Cell, Vol. 24, Issue 4 https://doi.org/10.1016/j.molcel.2006.10.021	journal	November 2006
SOSS Complexes Participate in the Maintenance of Genomic Stability Huang, Jun; Gong, Zihua; Ghosal, Gargi Molecular Cell, Vol. 35, Issue 3 https://doi.org/10.1016/j.molcel.2009.06.011	journal	August 2009
Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways Mladenov, Emil; Iliakis, George Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 711, Issue 1-2 https://doi.org/10.1016/j.mrfmmm.2011.02.005	journal	June 2011
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography Thompson, Larry H. Mutation Research/Reviews in Mutation Research, Vol. 751, Issue 2 https://doi.org/10.1016/j.mrrev.2012.06.002	journal	October 2012
Sculpting of DNA at Abasic Sites by DNA Glycosylase Homolog Mag2 Dalhus, Bjørn; Nilsen, Line; Korvald, Hanne Structure, Vol. 21, Issue 1 https://doi.org/10.1016/j.str.2012.11.004	journal	January 2013
Translesion synthesis in mammalian cells Lehmann, Alan R. Experimental Cell Research, Vol. 312, Issue 14 https://doi.org/10.1016/j.yexcr.2006.06.010	journal	August 2006
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution Putnam, Christopher D.; Hammel, Michal; Hura, Greg L. Quarterly Reviews of Biophysics, Vol. 40, Issue 3 https://doi.org/10.1017/S0033583507004635	journal	August 2007
A Non-Heme Iron-Mediated Chemical Demethylation in DNA and RNA Yi, Chengqi; Yang, Cai-Guang; He, Chuan Accounts of Chemical Research, Vol. 42, Issue 4 https://doi.org/10.1021/ar800178j	journal	April 2009
Heat-induced deamination of cytosine residues in deoxyribonucleic acid Lindahl, Tomas; Nyberg, Barbro Biochemistry, Vol. 13, Issue 16 https://doi.org/10.1021/bi00713a035	journal	July 1974
Effect of Flap Modifications on Human FEN1 Cleavage ^† Bornarth, Carole J.; Ranalli, Tamara A.; Henricksen, Leigh A. Biochemistry, Vol. 38, Issue 40 https://doi.org/10.1021/bi991321u	journal	October 1999
Plant homologue of flap endonuclease-1: molecular cloning, characterization, and evidence of expression in meristematic tissues Kimura, Seisuke; Ueda, Tadamasa; Hatanaka, Masami Plant Molecular Biology, Vol. 42, Issue 3, p. 415-427 https://doi.org/10.1023/A:1006349511964	journal	January 2000
A scaleable and integrated crystallization pipeline applied to mining the Thermotoga maritima proteome DiDonato, Michael; Deacon, Ashley M.; Klock, Heath E. Journal of Structural and Functional Genomics, Vol. 5, Issue 1/2 https://doi.org/10.1023/B:JSFG.0000029194.04443.50	journal	March 2004
The crystal structure of flap endonuclease-1 from Methanococcus jannaschii Hwang, Kwang Yeon; Baek, Kyuwon; Kim, Hye-Yeon Nature Structural & Molecular Biology, Vol. 5, Issue 8 https://doi.org/10.1038/1406	journal	August 1998
The structure of the E. coli recA protein monomer and polymer Story, Randall M.; Weber, Irene T.; Steitz, Thomas A. Nature, Vol. 355, Issue 6358 https://doi.org/10.1038/355318a0	journal	January 1992
A nucleotide-flipping mechanism from the structure of human uracil–DNA glycosylase bound to DNA Slupphaug, Geir; Mol, Clifford D.; Kavli, Bodil Nature, Vol. 384, Issue 6604 https://doi.org/10.1038/384087a0	journal	November 1996
Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA Bochkarev, Alexey; Pfuetzner, Richard A.; Edwards, Aled M. Nature, Vol. 385, Issue 6612 https://doi.org/10.1038/385176a0	journal	January 1997
Breast cancer genetics: What we know and what we need Nathanson, Katherine N.; Wooster, Richard; Weber, Barbara L. Nature Medicine, Vol. 7, Issue 5 https://doi.org/10.1038/87876	journal	May 2001
Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation: Crystal structure of an XPD-DNA complex Kuper, Jochen; Wolski, Stefanie C.; Michels, Gudrun The EMBO Journal, Vol. 31, Issue 2 https://doi.org/10.1038/emboj.2011.374	journal	November 2011
Insights into DNA recombination from the structure of a RAD51–BRCA2 complex Pellegrini, Luca; Yu, David S.; Lo, Thomas Nature, Vol. 420, Issue 6913 https://doi.org/10.1038/nature01230	journal	November 2002
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability Richard, Derek J.; Bolderson, Emma; Cubeddu, Liza Nature, Vol. 453, Issue 7195 https://doi.org/10.1038/nature06883	journal	April 2008
Flipping of alkylated DNA damage bridges base and nucleotide excision repair Tubbs, Julie L.; Latypov, Vitaly; Kanugula, Sreenivas Nature, Vol. 459, Issue 7248 https://doi.org/10.1038/nature08076	journal	June 2009
Microbial metalloproteomes are largely uncharacterized Cvetkovic, Aleksandar; Menon, Angeli Lal; Thorgersen, Michael P. Nature, Vol. 466, Issue 7307 https://doi.org/10.1038/nature09265	journal	July 2010
Accurate assessment of mass, models and resolution by small-angle scattering Rambo, Robert P.; Tainer, John A. Nature, Vol. 496, Issue 7446 https://doi.org/10.1038/nature12070	journal	April 2013
Cancer, cadmium and genome integrity McMurray, Cynthia T.; Tainer, John A. Nature Genetics, Vol. 34, Issue 3 https://doi.org/10.1038/ng0703-239	journal	July 2003
Fen1 mutations result in autoimmunity, chronic inflammation and cancers Zheng, Li; Dai, Huifang; Zhou, Mian Nature Medicine, Vol. 13, Issue 7 https://doi.org/10.1038/nm1599	journal	June 2007
Comprehensive macromolecular conformations mapped by quantitative SAXS analyses Hura, Greg L.; Budworth, Helen; Dyer, Kevin N. Nature Methods, Vol. 10, Issue 6 https://doi.org/10.1038/nmeth.2453	journal	April 2013
TFIIH: when transcription met DNA repair Compe, Emmanuel; Egly, Jean-Marc Nature Reviews Molecular Cell Biology, Vol. 13, Issue 6 https://doi.org/10.1038/nrm3350	journal	May 2012
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair Dalhus, Bjørn; Arvai, Andrew S.; Rosnes, Ida Nature Structural & Molecular Biology, Vol. 16, Issue 2 https://doi.org/10.1038/nsmb.1538	journal	January 2009
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair Williams, Gareth J.; Williams, R. Scott; Williams, Jessica S. Nature Structural & Molecular Biology, Vol. 18, Issue 4 https://doi.org/10.1038/nsmb.2038	journal	March 2011
Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling Schiller, Christian B.; Lammens, Katja; Guerini, Ilaria Nature Structural & Molecular Biology, Vol. 19, Issue 7 https://doi.org/10.1038/nsmb.2323	journal	June 2012
Crystal structure of a Rad51 filament Conway, Adam B.; Lynch, Thomas W.; Zhang, Ying Nature Structural & Molecular Biology, Vol. 11, Issue 8 https://doi.org/10.1038/nsmb795	journal	July 2004
Structural basis for recruitment of human flap endonuclease 1 to PCNA Sakurai, Shigeru; Kitano, Ken; Yamaguchi, Hiroto The EMBO Journal, Vol. 24, Issue 4 https://doi.org/10.1038/sj.emboj.7600519	journal	December 2004
Structural insights into the first incision reaction during nucleotide excision repair Truglio, James J.; Rhau, Benjamin; Croteau, Deborah L. The EMBO Journal, Vol. 24, Issue 5 https://doi.org/10.1038/sj.emboj.7600568	journal	February 2005
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage Sundheim, Ottar; Vågbø, Cathrine B.; Bjørås, Magnar The EMBO Journal, Vol. 25, Issue 14 https://doi.org/10.1038/sj.emboj.7601219	journal	July 2006
Hexameric structures of the archaeal secretion ATPase GspE and implications for a universal secretion mechanism Yamagata, Atsushi; Tainer, John A. The EMBO Journal, Vol. 26, Issue 3 https://doi.org/10.1038/sj.emboj.7601544	journal	January 2007
Archaeal flagellar ATPase motor shows ATP-dependent hexameric assembly and activity stimulation by specific lipid binding Ghosh, Abhrajyoti; Hartung, Sophia; van der Does, Chris Biochemical Journal, Vol. 437, Issue 1, p. 43-52 https://doi.org/10.1042/BJ20110410	journal	July 2011
DNA replication in thermophiles Majerník, A. I.; Jenkinson, E. R.; Chong, J. P. J. Biochemical Society Transactions, Vol. 32, Issue 2 https://doi.org/10.1042/BST0320236	journal	April 2004
RecA family proteins in archaea: RadA and its cousins Haldenby, Sam; White, Malcolm F.; Allers, Thorsten Biochemical Society Transactions, Vol. 37, Issue 1 https://doi.org/10.1042/BST0370102	journal	January 2009
Homologous recombination in the archaea: the means justify the ends White, Malcolm F. Biochemical Society Transactions, Vol. 39, Issue 1 https://doi.org/10.1042/BST0390015	journal	January 2011
The role of the DNA sliding clamp in Okazaki fragment maturation in archaea and eukaryotes Beattie, Thomas R.; Bell, Stephen D. Biochemical Society Transactions, Vol. 39, Issue 1 https://doi.org/10.1042/BST0390070	journal	January 2011
A brief history of the discovery of hyperthermophilic life Stetter, Karl O. Biochemical Society Transactions, Vol. 41, Issue 1 https://doi.org/10.1042/BST20120284	journal	January 2013
Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition Maiti, Atanu; Morgan, Michael T.; Pozharski, Edwin Proceedings of the National Academy of Sciences, Vol. 105, Issue 26 https://doi.org/10.1073/pnas.0711061105	journal	June 2008
Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA Yu, X.; Jacobs, S. A.; West, S. C. Proceedings of the National Academy of Sciences, Vol. 98, Issue 15 https://doi.org/10.1073/pnas.111005398	journal	July 2001
Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability Querol-Audi, J.; Yan, C.; Xu, X. Proceedings of the National Academy of Sciences, Vol. 109, Issue 22 https://doi.org/10.1073/pnas.1121116109	journal	May 2012
ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities Abdulrahman, W.; Iltis, I.; Radu, L. Proceedings of the National Academy of Sciences, Vol. 110, Issue 8 https://doi.org/10.1073/pnas.1213981110	journal	February 2013
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression Kucherlapati, M.; Yang, K.; Kuraguchi, M. Proceedings of the National Academy of Sciences, Vol. 99, Issue 15 https://doi.org/10.1073/pnas.152321699	journal	July 2002
Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures Barondeau, D. P.; Putnam, C. D.; Kassmann, C. J. Proceedings of the National Academy of Sciences, Vol. 100, Issue 21 https://doi.org/10.1073/pnas.2133463100	journal	October 2003
Isolation and Characterization of Recombination-Deficient Mutants of Escherichia coli k12 Clark, A. J.; Margulies, A. D. Proceedings of the National Academy of Sciences, Vol. 53, Issue 2 https://doi.org/10.1073/pnas.53.2.451	journal	February 1965
An N-Glycosidase from Escherichia coli That Releases Free Uracil from DNA Containing Deaminated Cytosine Residues Lindahl, T. Proceedings of the National Academy of Sciences, Vol. 71, Issue 9 https://doi.org/10.1073/pnas.71.9.3649	journal	September 1974
Classification of methanogenic bacteria by 16S ribosomal RNA characterization Fox, G. E.; Magrum, L. J.; Balch, W. E. Proceedings of the National Academy of Sciences, Vol. 74, Issue 10 https://doi.org/10.1073/pnas.74.10.4537	journal	October 1977
Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution Raghunathan, S.; Ricard, C. S.; Lohman, T. M. Proceedings of the National Academy of Sciences, Vol. 94, Issue 13 https://doi.org/10.1073/pnas.94.13.6652	journal	June 1997
Comparison of the 5' nuclease activities of Taq DNA polymerase and its isolated nuclease domain Lyamichev, V.; Brow, M. A. D.; Varvel, V. E. Proceedings of the National Academy of Sciences, Vol. 96, Issue 11 https://doi.org/10.1073/pnas.96.11.6143	journal	May 1999
A read-ahead function in archaeal DNA polymerases detects promutagenic template-strand uracil Greagg, M. A.; Fogg, M. J.; Panayotou, G. Proceedings of the National Academy of Sciences, Vol. 96, Issue 16 https://doi.org/10.1073/pnas.96.16.9045	journal	August 1999
A Single-stranded DNA-binding Protein Is Needed for Efficient Presynaptic Complex Formation by the Saccharomyces cerevisiae Rad51 Protein Sugiyama, Tomohiko; Zaitseva, Elena M.; Kowalczykowski, Stephen C. Journal of Biological Chemistry, Vol. 272, Issue 12 https://doi.org/10.1074/jbc.272.12.7940	journal	March 1997
RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2 Wong, Alexander K. C.; Pero, Ralph; Ormonde, Patricia A. Journal of Biological Chemistry, Vol. 272, Issue 51 https://doi.org/10.1074/jbc.272.51.31941	journal	December 1997
Newly Discovered Archaebacterial Flap Endonucleases Show a Structure-Specific Mechanism for DNA Substrate Binding and Catalysis Resembling Human Flap Endonuclease-1 Hosfield, David J.; Frank, Geoffrey; Weng, Yehua Journal of Biological Chemistry, Vol. 273, Issue 42 https://doi.org/10.1074/jbc.273.42.27154	journal	October 1998
Both RadA and RadB Are Involved in Homologous Recombination inPyrococcus furiosus Komori, Kayoko; Miyata, Tomoko; DiRuggiero, Jocelyne Journal of Biological Chemistry, Vol. 275, Issue 43 https://doi.org/10.1074/jbc.M004557200	journal	October 2000
Contacts between the 5′ Nuclease of DNA Polymerase I and Its DNA Substrate Xu, Yang; Potapova, Olga; Leschziner, Andres E. Journal of Biological Chemistry, Vol. 276, Issue 32 https://doi.org/10.1074/jbc.M100985200	journal	August 2001
Replication Protein A in Pyrococcus furiosus Is Involved in Homologous DNA Recombination Komori, Kayoko; Ishino, Yoshizumi Journal of Biological Chemistry, Vol. 276, Issue 28 https://doi.org/10.1074/jbc.M102423200	journal	July 2001
Biochemical Characterization of Uracil Processing Activities in the Hyperthermophilic Archaeon Pyrobaculum aerophilum Sartori, Alessandro A.; Schär, Primo; Fitz-Gibbon, Sorel Journal of Biological Chemistry, Vol. 276, Issue 32 https://doi.org/10.1074/jbc.M102985200	journal	August 2001
Dissection of the Regional Roles of the Archaeal Holliday Junction Resolvase Hjc by Structural and Mutational Analyses Nishino, Tatsuya; Komori, Kayoko; Ishino, Yoshizumi Journal of Biological Chemistry, Vol. 276, Issue 38 https://doi.org/10.1074/jbc.M104460200	journal	September 2001
Biochemical Characterization of the Human RAD51 Protein Tombline, Gregory; Fishel, Richard Journal of Biological Chemistry, Vol. 277, Issue 17 https://doi.org/10.1074/jbc.M109915200	journal	April 2002
Cleavage Specificity of Saccharomyces cerevisiae Flap Endonuclease 1 Suggests a Double-Flap Structure as the Cellular Substrate Kao, Hui-I; Henricksen, Leigh A.; Liu, Yuan Journal of Biological Chemistry, Vol. 277, Issue 17 https://doi.org/10.1074/jbc.M110662200	journal	February 2002
New Family of Deamination Repair Enzymes in Uracil-DNA Glycosylase Superfamily Lee, Hyun-Wook; Dominy, Brian N.; Cao, Weiguo Journal of Biological Chemistry, Vol. 286, Issue 36 https://doi.org/10.1074/jbc.M111.249524	journal	June 2011
Structural Tuning of the Fluorescent Protein iLOV for Improved Photostability Christie, John M.; Hitomi, Kenichi; Arvai, Andrew S. Journal of Biological Chemistry, Vol. 287, Issue 26 https://doi.org/10.1074/jbc.M111.318881	journal	May 2012
Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes Tsutakawa, Susan E.; Shin, David S.; Mol, Clifford D. Journal of Biological Chemistry, Vol. 288, Issue 12 https://doi.org/10.1074/jbc.M112.422774	journal	January 2013
The Iron-containing Domain Is Essential in Rad3 Helicases for Coupling of ATP Hydrolysis to DNA Translocation and for Targeting the Helicase to the Single-stranded DNA-Double-stranded DNA Junction Pugh, Robert A.; Honda, Masayoshi; Leesley, Haley Journal of Biological Chemistry, Vol. 283, Issue 3 https://doi.org/10.1074/jbc.M707064200	journal	January 2008
INTS3 controls the hSSB1-mediated DNA damage response Skaar, Jeffrey R.; Richard, Derek J.; Saraf, Anita Journal of Cell Biology, Vol. 187, Issue 1 https://doi.org/10.1083/jcb.200907026	journal	September 2009
Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death Sonoda, E. The EMBO Journal, Vol. 17, Issue 2 https://doi.org/10.1093/emboj/17.2.598	journal	January 1998
Structure and function of an archaeal topoisomerase VI subunit with homology to the meiotic recombination factor Spo11 Nichols, M. D. The EMBO Journal, Vol. 18, Issue 21 https://doi.org/10.1093/emboj/18.21.6177	journal	November 1999
Crystal structure of reverse gyrase: insights into the positive supercoiling of DNA Rodríguez, A. Chapin; Stock, Daniela The EMBO Journal, Vol. 21, Issue 3 https://doi.org/10.1093/emboj/21.3.418	journal	February 2002
A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site Sartori, A. A. The EMBO Journal, Vol. 21, Issue 12 https://doi.org/10.1093/emboj/cdf309	journal	June 2002
Specific interaction between DNA polymerase II (PolD) and RadB, a Rad51/Dmc1 homolog, in Pyrococcus furiosus Hayashi, I. Nucleic Acids Research, Vol. 27, Issue 24 https://doi.org/10.1093/nar/27.24.4695	journal	December 1999
Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF4: implications for decreased ATPase activity and molecular aggregation Datta, S. Nucleic Acids Research, Vol. 28, Issue 24 https://doi.org/10.1093/nar/28.24.4964	journal	December 2000
Unusually wide co-factor tolerance in a metalloenzyme; divalent metal ions modulate endo-exonuclease activity in T5 exonuclease Garforth, S. J. Nucleic Acids Research, Vol. 29, Issue 13 https://doi.org/10.1093/nar/29.13.2772	journal	July 2001
Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA Ariza, A. Nucleic Acids Research, Vol. 33, Issue 5 https://doi.org/10.1093/nar/gki288	journal	March 2005
Structure of RadB recombinase from a hyperthermophilic archaeon, Thermococcus kodakaraensis KOD1: an implication for the formation of a near-7-fold helical assembly Akiba, T. Nucleic Acids Research, Vol. 33, Issue 10 https://doi.org/10.1093/nar/gki662	journal	June 2005
Structural and functional insights into DNA-end processing by the archaeal HerA helicase–NurA nuclease complex Blackwood, John K.; Rzechorzek, Neil J.; Abrams, Andrew S. Nucleic Acids Research, Vol. 40, Issue 7 https://doi.org/10.1093/nar/gkr1157	journal	November 2011
DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster Wu, Y.; Brosh, R. M. Nucleic Acids Research, Vol. 40, Issue 10 https://doi.org/10.1093/nar/gks039	journal	January 2012
Roles of Functional Loops and the CD-Terminal Segment of a Single-Stranded DNA Binding Protein Elucidated by X-Ray Structure Analysis Matsumoto, T.; Morimoto, Y.; Shibata, N. Journal of Biochemistry, Vol. 127, Issue 2 https://doi.org/10.1093/oxfordjournals.jbchem.a022611	journal	February 2000
Crystal structure of the Mre11-Rad50-ATP S complex: understanding the interplay between Mre11 and Rad50 Lim, H. S.; Kim, J. S.; Park, Y. B. Genes & Development, Vol. 25, Issue 10 https://doi.org/10.1101/gad.2037811	journal	April 2011
Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair. Harrington, J. J.; Lieber, M. R. Genes & Development, Vol. 8, Issue 11 https://doi.org/10.1101/gad.8.11.1344	journal	June 1994
Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source Classen, Scott; Hura, Greg L.; Holton, James M. Journal of Applied Crystallography, Vol. 46, Issue 1 https://doi.org/10.1107/S0021889812048698	journal	January 2013
Crystallization and preliminary X-ray diffraction studies of Hje, a Holliday junction resolving enzyme from Sulfolobus solfataricus Middleton, Claire L.; Parker, Joanne L.; Richard, Derek J. Acta Crystallographica Section D Biological Crystallography, Vol. 59, Issue 1 https://doi.org/10.1107/S0907444902019546	journal	December 2002
Purification, crystallization and preliminary X-ray analysis of the PCNA2–PCNA3 complex from Sulfolobus tokodaii strain 7 Kawai, Akito; Higuchi, Shigesada; Tsunoda, Masaru Acta Crystallographica Section F Structural Biology and Crystallization Communications, Vol. 65, Issue 12 https://doi.org/10.1107/S1744309109044479	journal	November 2009
The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA Savvides, Savvas N.; Raghunathan, Srinivasan; Fütterer, Klaus Protein Science, Vol. 13, Issue 7 https://doi.org/10.1110/ps.04661904	journal	July 2004
Disruption and complementation of the selenocysteine biosynthesis pathway reveals a hierarchy of selenoprotein gene expression in the archaeon Methanococcus maripaludis: Hierarchy of selenoprotein expression in M. maripaludis Stock, Tilmann; Selzer, Mirjam; Connery, Sarah Molecular Microbiology, Vol. 82, Issue 3 https://doi.org/10.1111/j.1365-2958.2011.07850.x	journal	October 2011
DNA-Dependent RNA Polymerase from Halobacterium halobium Zillig, Wolfram; Stetter, Karl O.; Tobien, Michael European Journal of Biochemistry, Vol. 91, Issue 1 https://doi.org/10.1111/j.1432-1033.1978.tb20951.x	journal	November 1978
DNA-Dependent RNA Polymerase from the Archaebacterium Sulfolobus acidocaldarius Zillig, Wolfram; Stetter, Karl O.; Janekovic, Davorin European Journal of Biochemistry, Vol. 96, Issue 3 https://doi.org/10.1111/j.1432-1033.1979.tb13074.x	journal	June 1979
Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii Bult, C. J.; White, O.; Olsen, G. J. Science, Vol. 273, Issue 5278 https://doi.org/10.1126/science.273.5278.1058	journal	August 1996
Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA Redinbo, M. R. Science, Vol. 279, Issue 5356 https://doi.org/10.1126/science.279.5356.1504	journal	March 1998
A Model for the Mechanism of Human Topoisomerase I Stewart, L. Science, Vol. 279, Issue 5356 https://doi.org/10.1126/science.279.5356.1534	journal	March 1998
BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure Yang, H. Science, Vol. 297, Issue 5588 https://doi.org/10.1126/science.297.5588.1837	journal	September 2002
Genome Sequencing of a Genetically Tractable Pyrococcus furiosus Strain Reveals a Highly Dynamic Genome Bridger, S. L.; Lancaster, W. A.; Poole, F. L. Journal of Bacteriology, Vol. 194, Issue 15, p. 4097-4106 https://doi.org/10.1128/JB.00439-12	journal	May 2012
Problems with “Procaryote” Pace, Norman R. Journal of Bacteriology, Vol. 191, Issue 7 https://doi.org/10.1128/JB.01224-08	journal	January 2009
Aphidicolin inhibits growth and DNA synthesis in halophilic arachaebacteria. Forterre, P.; Elie, C.; Kohiyama, M. Journal of Bacteriology, Vol. 159, Issue 2 https://doi.org/10.1128/JB.159.2.800-802.1984	journal	January 1984
Disruption of the FEN-1/PCNA Interaction Results in DNA Replication Defects, Pulmonary Hypoplasia, Pancytopenia, and Newborn Lethality in Mice Zheng, Li; Dai, Huifang; Qiu, Junzhuan Molecular and Cellular Biology, Vol. 27, Issue 8 https://doi.org/10.1128/MCB.01652-06	journal	February 2007
A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Lim, D. S.; Hasty, P. Molecular and Cellular Biology, Vol. 16, Issue 12 https://doi.org/10.1128/MCB.16.12.7133	journal	December 1996
Identification of rad27 Mutations That Confer Differential Defects in Mutation Avoidance, Repeat Tract Instability, and Flap Cleavage Xie, Yali; Liu, Yuan; Argueso, Juan Lucas Molecular and Cellular Biology, Vol. 21, Issue 15 https://doi.org/10.1128/MCB.21.15.4889-4899.2001	journal	August 2001
Fen-1 Facilitates Homologous Recombination by Removing Divergent Sequences at DNA Break Ends Kikuchi, K.; Taniguchi, Y.; Hatanaka, A. Molecular and Cellular Biology, Vol. 25, Issue 16 https://doi.org/10.1128/MCB.25.16.6948-6955.2005	journal	July 2005
Rings in the Extreme: PCNA Interactions and Adaptations in the Archaea Winter, Jody A.; Bunting, Karen A. Archaea, Vol. 2012 https://doi.org/10.1155/2012/951010	journal	January 2012
On the traces of XPD: cell cycle matters - untangling the genotype-phenotype relationship of XPD mutations Cameroni, Elisabetta; Stettler, Karin; Suter, Beat Cell Division, Vol. 5, Issue 1 https://doi.org/10.1186/1747-1028-5-24	journal	January 2010
Crystal Structure of the FeS Cluster–Containing Nucleotide Excision Repair Helicase XPD Wolski, Stefanie C.; Kuper, Jochen; Hänzelmann, Petra PLoS Biology, Vol. 6, Issue 6 https://doi.org/10.1371/journal.pbio.0060149	journal	June 2008
Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana Kashiwagi, Sayo; Kuraoka, Isao; Fujiwara, Yoshie Journal of Nucleic Acids, Vol. 2010 https://doi.org/10.4061/2010/701472	journal	January 2010

Cited By (1)

Navigating the structure–function–evolutionary relationship of CsaA chaperone in archaea Sharma, Archana; Rani, Shikha; Goel, Manisha Critical Reviews in Microbiology, Vol. 44, Issue 3 https://doi.org/10.1080/1040841x.2017.1357535	journal	September 2017

Similar Records

The structure of a thermophilic archaeal virus shows a dsDNA viral capsid type that spans all domains of life

Journal Article · Sat May 01 00:00:00 EDT 2004 · Proceedings, National Academy of Sciences, USA · OSTI ID:912328

Modeling DNA Repair: Approaching In Vivo Techniques in the Hyperthermophile Sulfolobus Solfataricus

Journal Article · Fri Dec 31 23:00:00 EST 2004 · Journal of Undergraduate Research · OSTI ID:1051756

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Microbiology

Archaeal Genome Guardians Give Insights into Eukaryotic DNA Replication and Damage Response Proteins

Citation Formats

References (262)

Cited By (1)

Similar Records

Related Subjects