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Title: Occurrence of Cyclic di-GMP-Modulating Output Domains in Cyanobacteria: an Illuminating Perspective

Journal Article · · mBio (Online)
 [1];  [2];  [3];  [4];  [5]
  1. Michigan State Univ., East Lansing, MI (United States). Cellular and Molecular Biology Graduate Program; Michigan State Univ., East Lansing, MI (United States). Dept. of Energy Plant Research Lab.
  2. Michigan State Univ., East Lansing, MI (United States). Dept. of Microbiology and Molecular Genetics
  3. Michigan State Univ., East Lansing, MI (United States). Cellular and Molecular Biology Graduate Program; Michigan State Univ., East Lansing, MI (United States). Dept. of Microbiology and Molecular Genetics
  4. Michigan State Univ., East Lansing, MI (United States). Dept. of Zoology
  5. Michigan State Univ., East Lansing, MI (United States). Cellular and Molecular Biology Graduate Program; Michigan State Univ., East Lansing, MI (United States). Dept. of Energy Plant Research Lab.; Michigan State Univ., East Lansing, MI (United States). Dept. of Biochemistry and Molecular Biology
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Microorganisms use a variety of metabolites to respond to external stimuli, including second messengers that amplify primary signals and elicit biochemical changes in a cell. Levels of the second messenger cyclic dimeric GMP (c-di-GMP) are regulated by a variety of environmental stimuli and play a critical role in regulating cellular processes such as biofilm formation and cellular motility. Cyclic di-GMP signaling systems have been largely characterized in pathogenic bacteria; however, proteins that can impact the synthesis or degradation of c-di-GMP are prominent in cyanobacterial species and yet remain largely underexplored. In cyanobacteria, many putative c-di-GMP synthesis or degradation domains are found in genes that also harbor light-responsive signal input domains, suggesting that light is an important signal for altering c-di-GMP homeostasis. Indeed, c-di-GMP-associated domains are often the second most common output domain in photoreceptors—outnumbered only by a histidine kinase output domain. Cyanobacteria differ from other bacteria regarding the number and types of photoreceptor domains associated with c-di-GMP domains. Due to the widespread distribution of c-di-GMP domains in cyanobacteria, we investigated the evolutionary origin of a subset of genes. Phylogenetic analyses showed that c-di-GMP signaling systems were present early in cyanobacteria and c-di-GMP genes were both vertically and horizontally inherited during their evolution. Finally, we compared intracellular levels of c-di-GMP in two cyanobacterial species under different light qualities, confirming that light is an important factor for regulating this second messenger in vivo.

Research Organization:
Michigan State Univ., East Lansing, MI (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
Grant/Contract Number:
FG02-91ER20021
OSTI ID:
1626105
Journal Information:
mBio (Online), Vol. 4, Issue 4; ISSN 2150-7511
Publisher:
American Society for Microbiology (ASM)Copyright Statement
Country of Publication:
United States
Language:
English

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Cited By (13)

Light-controlled motility in prokaryotes and the problem of directional light perception journal October 2017
Tlr1612 is the major repressor of cell aggregation in the light-color-dependent c-di-GMP signaling network of Thermosynechococcus vulcanus journal March 2018
Intestinal GPS: bile and bicarbonate control cyclic di-GMP to provide Vibrio cholerae spatial cues within the small intestine journal November 2014
Light-mediated decreases in cyclic di-GMP levels are potentiated by pyocyanin and inhibit structure formation in Pseudomonas aeruginosa biofilms posted_content January 2019
The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2 journal June 2017
Homeostasis of Second Messenger Cyclic-di-AMP Is Critical for Cyanobacterial Fitness and Acclimation to Abiotic Stress journal May 2018
Regulation of biofilm formation and cellular buoyancy through modulating intracellular cyclic di-GMP levels in engineered cyanobacteria: Engineering c-di-GMP Levels in Cyanobacteria journal October 2015
Survival Strategies in the Aquatic and Terrestrial World: The Impact of Second Messengers on Cyanobacterial Processes journal November 2014
Three cyanobacteriochromes work together to form a light color-sensitive input system for c-di-GMP signaling of cell aggregation journal June 2015
Axenic Biofilm Formation and Aggregation by Synechocystis sp. Strain PCC 6803 Are Induced by Changes in Nutrient Concentration and Require Cell Surface Structures journal February 2019
Comparative genomics analysis of c-di-GMP metabolism and regulation in Microcystis aeruginosa journal March 2020
Light-dependent governance of cell shape dimensions in cyanobacteria journal May 2015
Comparative Genomic Analysis of a Novel Strain of Taiwan Hot-Spring Cyanobacterium Thermosynechococcus sp. CL-1 journal January 2020

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