Lynx web services for annotations and systems analysis of multi-gene disorders

Sulakhe, Dinanath; Taylor, Andrew; Balasubramanian, Sandhya; Feng, Bo; Xie, Bingqing; Börnigen, Daniela; Dave, Utpal J.; Foster, Ian T.; Gilliam, T. Conrad; Maltsev, Natalia

doi:10.1093/nar/gku517

Lynx web services for annotations and systems analysis of multi-gene disorders

Journal Article · Thu Jun 19 00:00:00 EDT 2014 · Nucleic Acids Research

DOI:https://doi.org/10.1093/nar/gku517· OSTI ID:1625538

Sulakhe, Dinanath ^[1]; Taylor, Andrew ^[2]; Balasubramanian, Sandhya ^[2]; Feng, Bo ^[3]; Xie, Bingqing ^[3]; Börnigen, Daniela ^[4]; Dave, Utpal J. ^[5]; Foster, Ian T. ^[5]; Gilliam, T. Conrad ^[6]; Maltsev, Natalia ^[6]

Univ. of Chicago, IL (United States). Computation Inst.; Argonne National Lab. (ANL), Argonne, IL (United States); DOE/OSTI
Univ. of Chicago, IL (United States). Dept. of Human Genetics
Illinois Inst. of Technology, Chicago, IL (United States). Dept. of Computer Science
Univ. of Chicago, IL (United States). Dept. of Human Genetics; Toyota Technological Inst. of Chicago, IL (United States)
Univ. of Chicago, IL (United States). Computation Inst.; Argonne National Lab. (ANL), Argonne, IL (United States)
Univ. of Chicago, IL (United States). Computation Inst.; Argonne National Lab. (ANL), Argonne, IL (United States); Univ. of Chicago, IL (United States). Dept. of Human Genetics

Lynx is a web-based integrated systems biology platform that supports annotation and analysis of experimental data and generation of weighted hypotheses on molecular mechanisms contributing to human phenotypes and disorders of interest. Lynx has integrated multiple classes of biomedical data (genomic, proteomic, pathways, phenotypic, toxicogenomic, contextual and others) from various public databases as well as manually curated data from our group and collaborators (LynxKB). Lynx provides tools for gene list enrichment analysis using multiple functional annotations and network-based gene prioritization. Lynx provides access to the integrated database and the analytical tools via REST based Web Services (http://lynx.ci.uchicago.edu/webservices.html). This comprises data retrieval services for specific functional annotations, services to search across the complete LynxKB (powered by Lucene), and services to access the analytical tools built within the Lynx platform.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1625538

Journal Information:: Nucleic Acids Research, Journal Name: Nucleic Acids Research Journal Issue: W1 Vol. 42; ISSN 0305-1048

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United States

Language:: English

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Exploring the Pharmacological Mechanism of the Herb Pair “HuangLian-GanJiang” against Colorectal Cancer Based on Network Pharmacology Gong, Benjiao; Kao, Yanlei; Zhang, Chenglin Evidence-Based Complementary and Alternative Medicine, Vol. 2019 https://doi.org/10.1155/2019/2735050	journal	November 2019
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