Paralogous Radiations of PIN Proteins with Multiple Origins of Noncanonical PIN Structure

Bennett, Tom; Brockington, Samuel F.; Rothfels, Carl; Graham, Sean W.; Stevenson, Dennis; Kutchan, Toni; Rolf, Megan; Thomas, Philip; Wong, Gane Ka-Shu; Leyser, Ottoline; Glover, Beverley J.; Harrison, C. Jill

doi:10.1093/molbev/msu147

Paralogous Radiations of PIN Proteins with Multiple Origins of Noncanonical PIN Structure

Journal Article · Wed Apr 23 00:00:00 EDT 2014 · Molecular Biology and Evolution

DOI:https://doi.org/10.1093/molbev/msu147· OSTI ID:1625399

Bennett, Tom ^[1]; Brockington, Samuel F. ^[2]; Rothfels, Carl ^[3]; Graham, Sean W. ^[4]; Stevenson, Dennis ^[5]; Kutchan, Toni ^[6]; Rolf, Megan ^[6]; Thomas, Philip ^[7]; Wong, Gane Ka-Shu ^[8]; Leyser, Ottoline ^[9]; Glover, Beverley J. ^[2]; Harrison, C. Jill ^[2]

Univ. of Cambridge (United Kingdom). Dept. of Plant Sciences; Univ. of Cambridge (United Kingdom). Sainsbury Lab.; DOE/OSTI
Univ. of Cambridge (United Kingdom). Dept. of Plant Sciences
Univ. of British Columbia, Vancouver, BC (Canada). Dept. of Zoology
Univ. of British Columbia, Vancouver, BC (Canada). Botanical Garden
The New York Botanical Garden, Bronx, NY (United States). Molecular Systematics
Donald Danforth Plant Science Center, St. Louis, MO (United States)
Royal Botanic Gardens Edinburgh, Scotland (United Kingdom)
Univ. of Alberta, Edmonton, AB (Canada). Dept. of Medicine; Univ. of Alberta, Edmonton, AB (Canada). Dept. of Biological Sciences; BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen (China)
Univ. of Cambridge (United Kingdom). Sainsbury Lab.

The plant hormone auxin is a conserved regulator of development which has been implicated in the generation of morphological novelty. PIN-FORMED1 (PIN) auxin efflux carriers are central to auxin function by regulating its distribution. PIN family members have divergent structures and cellular localizations, but the origin and evolutionary significance of this variation is unresolved. To characterize PIN family evolution, we have undertaken phylogenetic and structural analyses with a massive increase in taxon sampling over previous studies. Our phylogeny shows that following the divergence of the bryophyte and lycophyte lineages, two deep duplication events gave rise to three distinct lineages of PIN proteins in euphyllophytes. Subsequent independent radiations within each of these lineages were taxonomically asymmetric, giving rise to at least 21 clades of PIN proteins, of which 15 are revealed here for the first time. Although most PIN protein clades share a conserved canonical structure with a modular central loop domain, a small number of noncanonical clades dispersed across the phylogeny have highly divergent protein structure. We propose that PIN proteins underwent sub- and neofunctionalization with substantial modification to protein structure throughout plant evolution. Our results have important implications for plant evolution as they suggest that structurally divergent PIN proteins that arose in paralogous radiations contributed to the convergent evolution of organ systems in different land plant lineages.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1625399

Journal Information:: Molecular Biology and Evolution, Journal Name: Molecular Biology and Evolution Journal Issue: 8 Vol. 31; ISSN 0737-4038

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
Biochemistry & Molecular Biology
Evolutionary Biology
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auxin
auxin transport
phylogeny
plant evolution
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Paralogous Radiations of PIN Proteins with Multiple Origins of Noncanonical PIN Structure

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